DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Casp1 and Strica

DIOPT Version :9

Sequence 1:	NP_036894.3	Gene:	Casp1 / 25166	RGDID:	2274	Length:	402	Species:	Rattus norvegicus
Sequence 2:	NP_001260718.1	Gene:	Strica / 35528	FlyBaseID:	FBgn0033051	Length:	527	Species:	Drosophila melanogaster

Alignment Length:	331	Identity:	82/331 - (24%)
Similarity:	141/331 - (42%)	Gaps:	75/331 - (22%)

- Green bases have known domain annotations that are detailed below.

  Rat    94 SAETVFVTEDSKGGHPFSSETKEK----LNKEGGAFP---------GPSGSLKFCPLEIAQKLWK 145
            |..::|.:...:...|.||....|    |...||..|         ...|::. ..|.|::....
  Fly   243 SISSIFKSAPKQVDKPLSSTATPKPFISLGSSGGTKPKVTAVAQSQDAQGTIS-TSLGISKSSLT 306

  Rat   146 ENHSEIYPIMKTPTRTRLALIICNTDFQHLSR-RVGADVDLREMKLLLQDLGYTVKVKENLTALE 209
            :|..:       |.|   ..|..:..|.:.:. |.|:..|::.::...:.|...|:|..:.|.:.
  Fly   307 KNKLK-------PAR---VYIFNHERFDNKNEFRKGSAQDVKVLRATFEQLKCKVEVITDATLVT 361

  Rat   210 MTK-----ELKEFAACPEHKTSDSTFLVFMSHGLQEGICGITYSNEVAD-----ILKVDTIFQMM 264
            :.|     :.|:|    |.|:  :..||.:|||        |..:::|.     .|..|.:|.:
  Fly   362 IKKTVRMLQTKDF----EDKS--ALVLVILSHG--------TRHDQIAAKDDDYSLDDDVVFPI- 411

  Rat   265 NTLKCPSLKDKPKVIIIQACRGEKQGVVLLKDSVGNSEEGFLTDAIFEDDGIKKAHIEKDFIAFC 329
              |:..:||||||:|.:|||:|:.|        :|    ||:|||. :.:|      ..:.|..|
  Fly   412 --LRNRTLKDKPKLIFVQACKGDCQ--------LG----GFMTDAA-QPNG------SPNEILKC 455

  Rat   330 SSTPDN-VSWRHPVQGSLFIESLIKHMKEYAWSCDLEDIFRKVRFSFEQPDSRLQMPTTERVTLT 393
            .||.:. ||:| ...|:.||::|.:.:.....:.|::.|...||...:......|:|:... |||
  Fly   456 YSTYEGFVSFR-TEDGTPFIQTLCEALNRSGKTSDIDTIMMNVRQVVKMQSKDRQIPSVTS-TLT 518

  Rat   394 KRFYLF 399
            .: |:|
  Fly   519 SK-YVF 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Casp1	NP_036894.3	CARD_CASP1-like	6..87	CDD:260036
Casp1	NP_036894.3	CASc	152..400	CDD:214521	68/260 (26%)
Strica	NP_001260718.1	CASc	311..523	CDD:294037	67/260 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810