DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sp4 and Spps

DIOPT Version :9

Sequence 1:	NP_036893.1	Gene:	Sp4 / 25162	RGDID:	3741	Length:	783	Species:	Rattus norvegicus
Sequence 2:	NP_001262902.1	Gene:	Spps / 42882	FlyBaseID:	FBgn0039169	Length:	985	Species:	Drosophila melanogaster

Alignment Length:	891	Identity:	263/891 - (29%)
Similarity:	365/891 - (40%)	Gaps:	264/891 - (29%)

- Green bases have known domain annotations that are detailed below.

  Rat    98 NAWQLVASTPPASKENNVSQPASSSSSSSSS---NNGSSSPTKTK-SGNPSTPNQFQVIQV-QNP 157
            :|.....|.|||:       |.::..||.::   |..|::.::|: .|.|.||...|:|.: |.|
  Fly     6 SAASAATSAPPAT-------PLAAGGSSKATIPPNGASAAASQTQVHGAPGTPTMQQIINIHQMP 63

  Rat   158 --------SGSVQYQVIPQ-----LQTVEGQQIQINPTSSSSLQDLQGQI---QLISAGNNQAIL 206
                    :|:.|...:||     :|.:..|.:.|:...:..:.:|..|:   |.::....||.:
  Fly    64 PQFAGGAVAGNGQNAGMPQNMFQIVQPMPMQTVNIDGQEAIFIPNLNAQLATAQAVNFNGQQAFI 128

  Rat   207 TAANRTASGNIL--AQNLANQTVPVQIRPGVSIPLQLQTLPG---TQAQVVTTLPINIGGVTLAL 266
                 |.:|.||  .|..||        |..|..:|||.|.|   .|.|::|     |.|..:.:
  Fly   129 -----TPNGQILRAPQMAAN--------PAASNCIQLQQLNGLGQEQTQLIT-----IPGTNIQI 175

  Rat   267 PVINNVTAGGGTGQVGQPTTTTTDSGT----SNGNQLVSTPTTSTAPAS-TMPESPSSSTTCTTT 326
            ||.|.:.......||.|.|......||    :||:.:.::.|....|.| |:|.:.....|....
  Fly   176 PVTNLIQQQQQAQQVHQGTVQQQAQGTNASGANGSGVTNSGTAGQLPGSITIPGTNLQIPTSVAA 240

  Rat   327 ASTSLTSSDTLVSSADTGQYASTSASSSERTIEEPQTPAATESEAQSSSQLQ------------- 378
            |:..|.:...:.:....||.........:...:..|.||....:.|.:..:|
  Fly   241 ANGLLGNISNISNLLGGGQSIKLENGQLQMRPQLVQFPAPAMPQQQQTVAVQIPVQTANGQTIYQ 305

  Rat   379 ------------SNGIQNAQDQSNSLQ-----QVQIV-------------GQPILQQIQI----- 408
                        |.|:||.. |:.|||     |:||:             ||  :||:|:
  Fly   306 TVHVPVQAAATSSGGLQNLM-QAQSLQMPSASQMQIIPQFSQIAQIVTPNGQ--IQQVQLAMPYP 367

  Rat   409 ---------------QQPQQQIIQAIPPQSFQLQSGQTIQTIQQQPLQNVQ------LQAVN--- 449
                           ||.|||:.|....|..|.|.....|..|||..|.||      |||::
  Fly   368 QLPPNANIIHIQNPHQQQQQQVQQQQQQQQAQQQQQAQQQQAQQQQQQQVQAQHQQLLQAISDAS 432

  Rat   450 ------------------------PTQVLIRAPTL---------TPSGQISWQTVQVQNIQSLSN 481
                                    |.|:...|||.         ||....:.|.:.:|||..|..
  Fly   433 AGGQLPPNQPITITNAQGQQLTVIPAQLRPNAPTAPTPAPAGVPTPMQMPNLQALPIQNIPGLGQ 497

  Rat   482 LQVQN---------AGLSQQLTITPVSSSGGTTLAQI--------------------------AP 511
            :|:.:         |...|.||..|:|.....|..|:                          .|
  Fly   498 VQIIHANQLPPNLPANFQQVLTQLPMSHPQVQTQGQVQVMPKQEPQSPTQMITSIKQEPPDTFGP 562

  Rat   512 VAVAGAP----ITLNTA--QLASVPNLQTV--SVANLG-AAGVQVQGVPVTITSVAGQQQGQDGV 567
            ::..|.|    .|.|||  |...:..|.|.  |:::|. .|.:|:..:|...|:..........:
  Fly   563 ISATGNPPAPASTPNTASPQQQQIKFLHTESNSLSSLSIPASIQITALPQQATNTPNTPATTQPI 627

  Rat   568 KVQ---------------QATIAP-------VTVAVGGIANATIGAVSPDQLT-----QVHLQQ- 604
            .|.               |.||||       ||....| |.|:|.:.:....|     |.||..
  Fly   628 PVSLPARSKVNAVTTSSTQITIAPTGGQVVSVTTQARG-ATASIRSTNTSTTTITTPSQSHLNMN 691

  Rat   605 -------------GQQTSDAEVQPGKRLRRVACSCPNCREGEGRGSSEPGKKKQHVCHIEGCGKV 656
                         |..|:..|.:|  ||:||||:||||.:||    ....||:||:|||.||.||
  Fly   692 ISVASVGGAATGGGGGTATGEPKP--RLKRVACTCPNCTDGE----KHSDKKRQHICHITGCHKV 750

  Rat   657 YGKTSHLRAHLRWHTGERPFICNWMFCGKRFTRSDELQRHRRTHTGEKRFECPECSKRFMRSDHL 721
            ||||||||||||||||||||:|:|.|||||||||||||||||||||||||:|.||:|:|||||||
  Fly   751 YGKTSHLRAHLRWHTGERPFVCSWAFCGKRFTRSDELQRHRRTHTGEKRFQCQECNKKFMRSDHL 815

  Rat   722 SKHVKTHQNKKGGGTALAI-----VTSGELDSSVTEVLGSPRIVTV 762
            |||:|||...:.|...:.:     ...|....|::.|.|   |||:
  Fly   816 SKHIKTHFKSRSGVELIELSIKQETKGGNAPKSISTVNG---IVTI 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sp4	NP_036893.1	C2H2 Zn finger	648..670	CDD:275368	19/21 (90%)
		COG5048	<661..732	CDD:227381	60/70 (86%)
		zf-H2C2_2	662..689	CDD:290200	23/26 (88%)
		C2H2 Zn finger	678..700	CDD:275368	19/21 (90%)
		zf-H2C2_2	692..715	CDD:290200	19/22 (86%)
		zf-C2H2	706..728	CDD:278523	16/21 (76%)
		C2H2 Zn finger	708..728	CDD:275368	15/19 (79%)
Spps	NP_001262902.1	COG5048	<725..827	CDD:227381	80/105 (76%)
		C2H2 Zn finger	742..764	CDD:275368	19/21 (90%)
		zf-H2C2_2	756..783	CDD:290200	23/26 (88%)
		C2H2 Zn finger	772..794	CDD:275368	19/21 (90%)
		zf-H2C2_2	786..809	CDD:290200	19/22 (86%)
		zf-C2H2	800..822	CDD:278523	16/21 (76%)
		C2H2 Zn finger	802..822	CDD:275368	15/19 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10635
eggNOG	1	0.900	-	-		E33208_3BGI1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	242	1.000	Inparanoid score	I3237
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1085860at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46128
orthoMCL	1	0.900	-	-		OOG6_109416
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.870