Protein Alignment NR5A1 and Nr5a1

DIOPT Version :10

• Sequence 1: NP_004950.2
• Gene: NR5A1 / 2516
• HGNCID: 7983
• Length: 461
• Species: Homo sapiens
• Sequence 2: NP_001416430.1
• Gene: Nr5a1 / 83826
• RGDID: 68350
• Length: 498
• Species: Rattus norvegicus
• Alignment Length: 498
• Identity: 433/498 - (86%)
• Similarity: 443/498 - (88%)
• Gaps: 37/498 - (7%)

Human     1 MDYSYDEDLDELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKHYTCTESQSCKIDKTQRKRC 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat     1 MDYSYDEDLDELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKHYTCTESQSCKIDKTQRKRC 65

Human    66 PFCRFQKCLTVGMRLE------------------------------------AVRADRMRGGRNK 94
            ||||||||||||||||                                    |||||||||||||
  Rat    66 PFCRFQKCLTVGMRLEGARPARPGPLTAGRPQGAAGGPGRGAEGKAEQFLDPAVRADRMRGGRNK 130

Human    95 FGPMYKRDRALKQQKKAQIRANGFKLETGPPMGVPPPPPPAPDYVLPPSLHGPEPKGLAAGPPAG 159
            ||||||||||||||||||||||||||||||||||||||||.|||:||||||.||||.|.:|||:|
  Rat   131 FGPMYKRDRALKQQKKAQIRANGFKLETGPPMGVPPPPPPPPDYMLPPSLHAPEPKALVSGPPSG 195

Human   160 PLGDFGAPALPMAVPGAHGPLAGYLYPAFPGRAIKSEYPEPYASPP-QPGLPYGYPEPFSGGPNV 223
            ||||||||:|||||||.||||||||||||..|.||||||||||||| |||.||.|||||||||||
  Rat   196 PLGDFGAPSLPMAVPGPHGPLAGYLYPAFSNRTIKSEYPEPYASPPQQPGPPYSYPEPFSGGPNV 260

Human   224 PELILQLLQLEPDEDQVRARILGCLQEPTKSRPDQPAAFGLLCRMADQTFISIVDWARRCMVFKE 288
            ||||||||||||:||||||||:||||||.||||||||.|.|||||||||||||||||||||||||
  Rat   261 PELILQLLQLEPEEDQVRARIVGCLQEPAKSRPDQPAPFSLLCRMADQTFISIVDWARRCMVFKE 325

Human   289 LEVADQMTLLQNCWSELLVFDHIYRQVQHGKEGSILLVTGQEVELTTVATQAGSLLHSLVLRAQE 353
            |||||||||||||||||||.||||||||:|||.||||||||||||:|||.|||||||||||||||
  Rat   326 LEVADQMTLLQNCWSELLVLDHIYRQVQYGKEDSILLVTGQEVELSTVAVQAGSLLHSLVLRAQE 390

Human   354 LVLQLLALQLDRQEFVCLKFIILFSLDLKFLNNHILVKDAQEKANAALLDYTLCHYPHCGDKFQQ 418
            |||||.||||||||||||||:||||||:||||||.||||||||||||||||||||||||||||||
  Rat   391 LVLQLHALQLDRQEFVCLKFLILFSLDVKFLNNHSLVKDAQEKANAALLDYTLCHYPHCGDKFQQ 455

Human   419 LLLCLVEVRALSMQAKEYLYHKHLGNEMPRNNLLIEMLQAKQT 461
            |||||||||||||||||||||||||||||||||||||||||||
  Rat   456 LLLCLVEVRALSMQAKEYLYHKHLGNEMPRNNLLIEMLQAKQT 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NR5A1	NP_004950.2	NR_DBD_Lrh-1_like	13..105	CDD:143541	91/127 (72%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	119..157		31/37 (84%)
		PHA03247	<137..216	CDD:223021	65/79 (82%)
		NR_LBD_SF-1	223..459	CDD:132755	221/235 (94%)
		Important for dimerization	230..461		216/230 (94%)
Nr5a1	NP_001416430.1	NR_DBD_Lrh-1_like	13..141	CDD:143541	91/127 (72%)
		Atrophin-1	<183..>300	CDD:460830	100/116 (86%)
		NR_LBD_SF-1	260..496	CDD:132755	221/235 (94%)