Protein Alignment NR5A1 and nr5a1b

DIOPT Version :10

• Sequence 1: NP_004950.2
• Gene: NR5A1 / 2516
• HGNCID: 7983
• Length: 461
• Species: Homo sapiens
• Sequence 2: NP_997999.1
• Gene: nr5a1b / 405759
• ZFINID: ZDB-GENE-040702-6
• Length: 502
• Species: Danio rerio
• Alignment Length: 504
• Identity: 287/504 - (56%)
• Similarity: 344/504 - (68%)
• Gaps: 47/504 - (9%)

Human     1 MDYSYDEDLDELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKHYTCTESQSCKIDKTQRKRC 65
            ||||||.||:|:|||||||||||||||||||||||||||||||||.|||.|||.|||||||||||
Zfish     1 MDYSYDADLEEMCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCAESQDCKIDKTQRKRC 65

Human    66 PFCRFQKCLTVGMRLEAVRADRMRGGRNKFGPMYKRDRALKQQKKAQIRANGFKLETGPPMGVPP 130
            |||||||||.||||||||||||||||||||||||||||||||||||.|||:|.|:|..||:
Zfish    66 PFCRFQKCLNVGMRLEAVRADRMRGGRNKFGPMYKRDRALKQQKKALIRASGLKMEATPPL---- 126

Human   131 PPPPAPDYVLPPSLHGPEPKG------LAAGPPAGPLGDFGAPALPMAVP-GAHGPL-AGYLYPA 187
            ...|.|||....:|..|.||.      .:..|.......:.:.:|.::|| .||.|| |.|.||.
Zfish   127 LTSPQPDYTFSTALSVPAPKNTHPNIVTSVAPTDYERSLYASSSLSLSVPIPAHTPLPAQYPYPN 191

Human   188 FPGRAIKSEYPEPY--------ASPPQ--PGLPY-------GYPEPFSGGPNVPELILQLLQLEP 235
            .|.||||||||:.|        ||.|:  ||..|       ..|:..:.|..||.|:|:.::.|.
Zfish   192 LPSRAIKSEYPDHYTSSEHYTSASSPESVPGYTYIEQTRVSSSPQVVAPGLTVPPLVLEFVRCEQ 256

Human   236 DEDQVRARI---LGCLQEPTKSR---------------PDQPAAFGLLCRMADQTFISIVDWARR 282
            ||.||:::|   |..||:...||               |::.:.|||:|.|||||..|||:|||.
Zfish   257 DELQVQSKISAHLAHLQQEQNSRSTAANQEQSSRLAAKPERLSTFGLMCHMADQTLFSIVEWARS 321

Human   283 CMVFKELEVADQMTLLQNCWSELLVFDHIYRQVQHGKEGSILLVTGQEVELTTVATQAGSLLHSL 347
            |:.||||:|.|||.||.||||||||.|::.||:.||||.|:||:|||||||.::..|||..|..:
Zfish   322 CIFFKELKVGDQMKLLHNCWSELLVLDYVARQLHHGKEDSVLLITGQEVELASLLAQAGVTLSGM 386

Human   348 VLRAQELVLQLLALQLDRQEFVCLKFIILFSLDLKFLNNHILVKDAQEKANAALLDYTLCHYPHC 412
            :.|.||||.:|..|||||:|..|||::|||:.|:|.|.|...|:...|:.|||||:||||.||..
Zfish   387 IQRGQELVQRLQELQLDRRETACLKYLILFNPDVKLLENQPYVESVYEQVNAALLEYTLCAYPQF 451

Human   413 GDKFQQLLLCLVEVRALSMQAKEYLYHKHLGNEMPRNNLLIEMLQAKQT 461
            .|:|.|:||.|.|:||||.||::||.:|||..|:|.||||||||.||:|
Zfish   452 PDRFSQILLRLPELRALSSQAEDYLCYKHLSGEVPCNNLLIEMLHAKRT 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NR5A1	NP_004950.2	NR_DBD_Lrh-1_like	13..105	CDD:143541	87/91 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	119..157		12/43 (28%)
		PHA03247	<137..216	CDD:223021	35/103 (34%)
		NR_LBD_SF-1	223..459	CDD:132755	134/253 (53%)
		Important for dimerization	230..461		132/248 (53%)
nr5a1b	NP_997999.1	NR_DBD_Lrh-1_like	13..105	CDD:143541	87/91 (96%)
		NR_LBD_Ftz-F1_like	244..498	CDD:132742	134/253 (53%)