DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NR5A1 and ftz-f1

DIOPT Version :9

Sequence 1:	NP_004950.2	Gene:	NR5A1 / 2516	HGNCID:	7983	Length:	461	Species:	Homo sapiens
Sequence 2:	NP_524143.2	Gene:	ftz-f1 / 40045	FlyBaseID:	FBgn0001078	Length:	1027	Species:	Drosophila melanogaster

Alignment Length:	537	Identity:	196/537 - (36%)
Similarity:	269/537 - (50%)	Gaps:	102/537 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    10 DELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKHYTCTESQSCKIDKTQRKRCPFCRFQKCL 74
            :|||||||||||||||||||||||||||||||||.|.|||...:||.||||||||||:|||||||
  Fly   505 EELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNKKVYTCVAERSCHIDKTQRKRCPYCRFQKCL 569

Human    75 TVGMRLEAVRADRMRGGRNKFGPMYKRDRALKQQ--KKAQIRANGFKLETGPPMGVPPPPPPAPD 137
            .|||:|||||||||||||||||||||||||.|.|  ::.|:.....:...||.:   .|.|.:|.
  Fly   570 EVGMKLEAVRADRMRGGRNKFGPMYKRDRARKLQVMRQRQLALQALRNSMGPDI---KPTPISPG 631

Human   138 YV-------LPPSLHGPEPKGLAAGPPAGP------LGDF-----GAPALPM-AVPGAHGPLAGY 183
            |.       :...:..|:...|...|.:.|      ||..     |..|.|| |..|..|. .|.
  Fly   632 YQQAYPNMNIKQEIQIPQVSSLTQSPDSSPSPIAIALGQVNASTGGVIATPMNAGTGGSGG-GGL 695

Human   184 LYPAFPGRAIKSEYPEPYASPPQPGLPYGYPEPFSGGPN-------------------------- 222
            ..|:..|....|.    .:|........|......||.|
  Fly   696 NGPSSVGNGNSSN----GSSNGNNNSSTGNGTSGGGGGNNAGGGGGGTNSNDGLHRNGGNGNSSC 756

Human   223 --------------------------VPELILQLLQLEP---------DEDQVRARILGCLQEPT 252
                                      ..:.:::.|::.|         |:.:.:.::...||:.|
  Fly   757 HEAGIGSLQNTADSKLCFDSGTHPSSTADALIEPLRVSPMIREFVQSIDDREWQTQLFALLQKQT 821

Human   253 KSRPDQPAAFGLLCRMADQTFISIVDWARRCMVFKELEVADQMTLLQNCWSELLVFDHIYRQVQH 317
            .::.:.. .|.|:|::.||...|.|||||..:.||:|:|.|||.|||:.||::||.||::.::.:
  Fly   822 YNQVEVD-LFELMCKVLDQNLFSQVDWARNTVFFKDLKVDDQMKLLQHSWSDMLVLDHLHHRIHN 885

Human   318 GKEGSILLVTGQEVELTTV----ATQAGSLLHSLVLRAQELVLQLLALQLDRQEFVCLKFIILFS 378
            |......|..||...|.::    ..|.|...:.|..:.|:       |:.|..::||:||:||.:
  Fly   886 GLPDETQLNNGQVFNLMSLGLLGVPQLGDYFNELQNKLQD-------LKFDMGDYVCMKFLILLN 943

Human   379 LDLKFLNNHILVKDAQEKANAALLDYTLCHYPHCGDKFQQLLLCLVEVRALSMQAKEYLYHKHLG 443
            ..::.:.|...|.:..:...||||||||..||...|||:.|:..|.|:.|::::.:::||.||..
  Fly   944 PSVRGIVNRKTVSEGHDNVQAALLDYTLTCYPSVNDKFRGLVNILPEIHAMAVRGEDHLYTKHCA 1008

Human   444 NEMPRNNLLIEMLQAKQ 460
            ...|...||:|||.||:
  Fly  1009 GSAPTQTLLMEMLHAKR 1025

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NR5A1	NP_004950.2	NR_DBD_Lrh-1_like	13..105	CDD:143541	81/91 (89%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	119..157		8/44 (18%)
		MISS	<140..>221	CDD:318115	20/92 (22%)
		NR_LBD_SF-1	223..459	CDD:132755	79/248 (32%)
		Important for dimerization	230..461		81/244 (33%)
ftz-f1	NP_524143.2	NR_DBD_Lrh-1_like	508..600	CDD:143541	81/91 (89%)
ftz-f1	NP_524143.2	NR_LBD_Ftz-F1_like	794..1024	CDD:132742	78/237 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156773
Domainoid	1	1.000	148	1.000	Domainoid score	I4480
eggNOG	1	0.900	-	-		E1_KOG4218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	379	1.000	Inparanoid score	I2074
Isobase	1	0.950	-	0	Normalized mean entropy	S5899
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278717at33208
OrthoFinder	1	1.000	-	-		FOG0002223
OrthoInspector	1	1.000	-	-		otm41002
orthoMCL	1	0.900	-	-		OOG6_105772
Panther	1	1.100	-	-	O	PTHR24086
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2678
SonicParanoid	1	1.000	-	-		X1468
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.740