DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NR5A1 and Hr39

DIOPT Version :9

Sequence 1:	NP_004950.2	Gene:	NR5A1 / 2516	HGNCID:	7983	Length:	461	Species:	Homo sapiens
Sequence 2:	NP_476932.1	Gene:	Hr39 / 35398	FlyBaseID:	FBgn0261239	Length:	808	Species:	Drosophila melanogaster

Alignment Length:	499	Identity:	150/499 - (30%)
Similarity:	219/499 - (43%)	Gaps:	119/499 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    13 CPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKHYTCTESQSCKIDKTQRKRCPFCRFQKCLTVG 77
            ||:||||:||:|||:.:||||||||||||||.|:|.|.....|::..:.||:||.|||:|||..|
  Fly   376 CPICGDKISGFHYGIFSCESCKGFFKRTVQNRKNYVCVRGGPCQVSISTRKKCPACRFEKCLQKG 440

Human    78 MRLEAVRADRMRGGRNKFGPMYKRDRALKQQKKAQIRANGFKLETGPPMGVPPPPPPAPDYVLPP 142
            |:|||:|.||.||||:.:...|                                  ..|:.:|.|
  Fly   441 MKLEAIREDRTRGGRSTYQCSY----------------------------------TLPNSMLSP 471

Human   143 SLHGPEPKGLAAGPPA-----------GPLGDFGAPALP--MAVPGAHGPLAGYLYPAFPGRAIK 194
            .| .|:....||...|           ..|..||...:|  .::|.:         |:..|.::|
  Fly   472 LL-SPDQAAAAAAAAAVASQQQPHQRLHQLNGFGGVPIPCSTSLPAS---------PSLAGTSVK 526

Human   195 SEYPEPYASPPQPGLPYGYPEPFSGGPNVPELILQLLQLE---PDEDQVRARI------------ 244
            |   |..|...:..|..|         :||.|:.:::.:|   ...|...|||
  Fly   527 S---EEMAETGKQSLRTG---------SVPPLLQEIMDVEHLWQYTDAELARINQPLSAFASGSS 579

Human   245 -----------------------LGCLQEPTKSRPDQPAAFGLLCRMADQTFISIVDWARRCMVF 286
                                   .|.......:.||..|.   ||.:||.....||.|.:...:|
  Fly   580 SSSSSSGTSSGAHAQLTNPLLASAGLSSNGENANPDLIAH---LCNVADHRLYKIVKWCKSLPLF 641

Human   287 KELEVADQMTLLQNCWSELLVFDHIYRQVQHGKEGSILLVTGQEVELTTVATQAGSLLHSLVLRA 351
            |.:.:.||:.||.|.|.|||:|...:|.:.  ..|.|.:..|:::.|:...:..   |.:.:.|.
  Fly   642 KNISIDDQICLLINSWCELLLFSCCFRSID--TPGEIKMSQGRKITLSQAKSNG---LQTCIERM 701

Human   352 QELVLQLLALQLDRQEFVCLKFIILFSLDLKFLNNHILVKDAQEKANAALLDYTLCHYPHCGDKF 416
            ..|...|..|::||.|:|.:|.|:|...|...|...:.|::.||||..:|..|||.|||....||
  Fly   702 LNLTDHLRRLRVDRYEYVAMKVIVLLQSDTTELQEAVKVRECQEKALQSLQAYTLAHYPDTPSKF 766

Human   417 QQLLLCLVEVRALSMQAKEYLYHK-HLGNEMPRNNLLIEMLQAK 459
            .:|||.:.:::......||.|..| ..|.:.   |||:|:|:.:
  Fly   767 GELLLRIPDLQRTCQLGKEMLTIKTRDGADF---NLLMELLRGE 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NR5A1	NP_004950.2	NR_DBD_Lrh-1_like	13..105	CDD:143541	52/91 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	119..157		7/37 (19%)
		MISS	<140..>221	CDD:318115	20/93 (22%)
		NR_LBD_SF-1	223..459	CDD:132755	77/274 (28%)
		Important for dimerization	230..461		74/269 (28%)
Hr39	NP_476932.1	NR_DBD_Lrh-1_like	376..468	CDD:143541	53/125 (42%)
Hr39	NP_476932.1	NR_LBD_F2	617..779	CDD:132728	56/169 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156771
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278717at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24086
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.950