Protein Alignment NR5A1 and Nr5a1

DIOPT Version :10

• Sequence 1: NP_004950.2
• Gene: NR5A1 / 2516
• HGNCID: 7983
• Length: 461
• Species: Homo sapiens
• Sequence 2: NP_620639.1
• Gene: Nr5a1 / 26423
• MGIID: 1346833
• Length: 462
• Species: Mus musculus
• Alignment Length: 462
• Identity: 432/462 - (93%)
• Similarity: 442/462 - (95%)
• Gaps: 1/462 - (0%)

Human     1 MDYSYDEDLDELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKHYTCTESQSCKIDKTQRKRC 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse     1 MDYSYDEDLDELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKHYTCTESQSCKIDKTQRKRC 65

Human    66 PFCRFQKCLTVGMRLEAVRADRMRGGRNKFGPMYKRDRALKQQKKAQIRANGFKLETGPPMGVPP 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    66 PFCRFQKCLTVGMRLEAVRADRMRGGRNKFGPMYKRDRALKQQKKAQIRANGFKLETGPPMGVPP 130

Human   131 PPPPAPDYVLPPSLHGPEPKGLAAGPPAGPLGDFGAPALPMAVPGAHGPLAGYLYPAFPGRAIKS 195
            ||||.|||:||||||.||||.|.:|||:|||||||||:|||||||.||||||||||||..|.|||
Mouse   131 PPPPPPDYMLPPSLHAPEPKALVSGPPSGPLGDFGAPSLPMAVPGPHGPLAGYLYPAFSNRTIKS 195

Human   196 EYPEPYASPP-QPGLPYGYPEPFSGGPNVPELILQLLQLEPDEDQVRARILGCLQEPTKSRPDQP 259
            |||||||||| |||.||.|||||||||||||||||||||||:||||||||:||||||.|||.|||
Mouse   196 EYPEPYASPPQQPGPPYSYPEPFSGGPNVPELILQLLQLEPEEDQVRARIVGCLQEPAKSRSDQP 260

Human   260 AAFGLLCRMADQTFISIVDWARRCMVFKELEVADQMTLLQNCWSELLVFDHIYRQVQHGKEGSIL 324
            |.|.||||||||||||||||||||||||||||||||||||||||||||.||||||||:|||.|||
Mouse   261 APFSLLCRMADQTFISIVDWARRCMVFKELEVADQMTLLQNCWSELLVLDHIYRQVQYGKEDSIL 325

Human   325 LVTGQEVELTTVATQAGSLLHSLVLRAQELVLQLLALQLDRQEFVCLKFIILFSLDLKFLNNHIL 389
            |||||||||:|||.||||||||||||||||||||.||||||||||||||:||||||:||||||.|
Mouse   326 LVTGQEVELSTVAVQAGSLLHSLVLRAQELVLQLHALQLDRQEFVCLKFLILFSLDVKFLNNHSL 390

Human   390 VKDAQEKANAALLDYTLCHYPHCGDKFQQLLLCLVEVRALSMQAKEYLYHKHLGNEMPRNNLLIE 454
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   391 VKDAQEKANAALLDYTLCHYPHCGDKFQQLLLCLVEVRALSMQAKEYLYHKHLGNEMPRNNLLIE 455

Human   455 MLQAKQT 461
            |||||||
Mouse   456 MLQAKQT 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NR5A1	NP_004950.2	NR_DBD_Lrh-1_like	13..105	CDD:143541	91/91 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	119..157		31/37 (84%)
		PHA03247	<137..216	CDD:223021	65/79 (82%)
		NR_LBD_SF-1	223..459	CDD:132755	220/235 (94%)
		Important for dimerization	230..461		215/230 (93%)
Nr5a1	NP_620639.1	NR_DBD_Lrh-1_like	13..105	CDD:143541	91/91 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	117..149		28/31 (90%)
		Atrophin-1	<147..>264	CDD:460830	99/116 (85%)
		NR_LBD_SF-1	237..460	CDD:132755	207/222 (93%)