Protein Alignment NR5A1 and nhr-25

DIOPT Version :10

• Sequence 1: NP_004950.2
• Gene: NR5A1 / 2516
• HGNCID: 7983
• Length: 461
• Species: Homo sapiens
• Sequence 2: NP_001024550.1
• Gene: nhr-25 / 181432
• WormBaseID: WBGene00003623
• Length: 572
• Species: Caenorhabditis elegans
• Alignment Length: 565
• Identity: 154/565 - (27%)
• Similarity: 231/565 - (40%)
• Gaps: 163/565 - (28%)

Human    11 ELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKHYTCTESQSCKIDKTQRKRCPFCRFQKCLT 75
            |:||||||:||||||||||||||||||||||||.|.|.|:...:|.:|:|.|||||.||||||||
 Worm    16 EMCPVCGDRVSGYHYGLLTCESCKGFFKRTVQNKKQYQCSAEANCHVDRTCRKRCPSCRFQKCLT 80

Human    76 VGMRLEAVRADRMRGGRNKFGPMYKRDRALKQQKKAQIRANGFKLETGPPMGVPPPPPPAPDYVL 140
            :||::||||||||||||||||..||:|||.:.|:      |..::.|.....|......|..:..
 Worm    81 MGMKMEAVRADRMRGGRNKFGSFYKKDRAHRMQR------NAMRVSTVQVPAVLGAQSQAQTFYQ 139

Human   141 PP--------------------------------SLHGPEPKGLAAGPPAGPLGDFGAPALPMAV 173
            ||                                ..|...|...::......:.||      :..
 Worm   140 PPEHQVSSSTTDQNNQINYFDQTKIKTEYIKTEYDAHLQSPTLSSSTNQQLSVSDF------IMR 198

Human   174 PG----AHGPLAGYLYPAFPGRAIKSEYPEPYASPPQPGLPYGYPEPF----------------- 217
            ||    ....||..|........::..:|..|........|:.|.|.|
 Worm   199 PGYLVDPQDSLAVLLGSTIDDPLLRHTFPAAYQLNEVKQEPFDYSEQFIHHSLHDYPTYTSNTTN 263

Human   218 --------------------------------SGGPNVP---------------ELILQLLQLEP 235
                                            |..|.:|               ..|.::.:..|
 Worm   264 YATMMPMTTVSSTQSLVTSTSSTTTGRMTEASSTSPILPLCPAPTEKTVDHFYNSSIAEMCKTLP 328

Human   236 DEDQVRARILGCLQEPTKSRPDQPAAFGLLCRMADQTFISIVDWARRCMVFKELEVADQMTLLQN 300
            |:.|: |||...::..:|     |.......::|::....||.||:...:|.:|.:.|||.|||.
 Worm   329 DDAQI-ARIFTSVKGTSK-----PEKHAFSIQVAEENLKDIVIWAKNDQLFSKLSLDDQMILLQT 387

Human   301 CWSELLVFDHIYRQVQHGKEGSIL----LVTGQEVELTTVATQAGSLLHSLVLRAQELVLQLLAL 361
            .|:.:.:.| |...:.|   |::|    :..|.||.:..||....   .:.|....::|::|..:
 Worm   388 SWTTVHIVD-ITNAMVH---GNLLSQYKMSNGDEVPVGLVALLGN---QTFVSSWNDVVIRLRNM 445

Human   362 QLDRQEFVCLKFIILF--SLD----LKFLNNHILVKDAQEKANAALLDYTLCHYPHCGDKFQQLL 420
            .....::...:|:.||  |:|    :....:.:|....:.:...|.|:.           |:|
 Worm   446 GFTNFDYCAFRFLALFDQSMDSFPAVSTARSRVLQSWREVRCTTAFLEI-----------FEQ-- 497

Human   421 LCLVEVRALSMQAKEYLYHKHLGNEMPRN--------NLLIEMLQ 457
                 :|.|:..:..||::.|  :..|.|        :|::||::
 Worm   498 -----IRRLAYDSLRYLWNLH--SNCPTNWEQFFPEASLVLEMIR 535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NR5A1	NP_004950.2	NR_DBD_Lrh-1_like	13..105	CDD:143541	71/91 (78%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	119..157		7/69 (10%)
		PHA03247	<137..216	CDD:223021	15/114 (13%)
		NR_LBD_SF-1	223..459	CDD:132755	57/268 (21%)
		Important for dimerization	230..461		55/246 (22%)
nhr-25	NP_001024550.1	NR_DBD_Lrh-1_like	18..110	CDD:143541	71/91 (78%)
		NR_LBD_F2	349..501	CDD:132728	38/176 (22%)