Protein Alignment NR5A1 and nr5a1

DIOPT Version :10

• Sequence 1: NP_004950.2
• Gene: NR5A1 / 2516
• HGNCID: 7983
• Length: 461
• Species: Homo sapiens
• Sequence 2: XP_031746117.1
• Gene: nr5a1 / 100271747
• XenbaseID: XB-GENE-485361
• Length: 496
• Species: Xenopus tropicalis
• Alignment Length: 472
• Identity: 321/472 - (68%)
• Similarity: 372/472 - (78%)
• Gaps: 17/472 - (3%)

Human     1 MDYSYDEDLDELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKHYTCTESQSCKIDKTQRKRC 65
            |||:|||||||||||||||||||||||||||||||||||||||||.|||||:|||||||||||||
 Frog    29 MDYNYDEDLDELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCTENQSCKIDKTQRKRC 93

Human    66 PFCRFQKCLTVGMRLEAVRADRMRGGRNKFGPMYKRDRALKQQKKAQIRANGFKLETGPPMGVPP 130
            |:|||||||.||||||||||||||||||||||||||||||||||||.|||||.||||.|.:
 Frog    94 PYCRFQKCLNVGMRLEAVRADRMRGGRNKFGPMYKRDRALKQQKKALIRANGIKLETVPQI---- 154

Human   131 PPPPAPDYVLPPSLH--GPEPKGLAAGP-PAGPL----GDFGAPALPMAVPGAHGPLAGYLYPAF 188
            ..|...||.:..::|  .|..|.|...| |..|:    |.:|.|.|.|.:|. |.||:.|.|..|
 Frog   155 VSPAHSDYAVSTNIHTIHPVTKNLPPNPAPMTPVEYDRGPYGPPPLGMTMPN-HTPLSSYQYSNF 218

Human   189 PGRAIKSEYPEPYASPPQPGL--PYGYPE--PFSGGPNVPELILQLLQLEPDEDQVRARILGCL- 248
            ..|.||||||:.|.:...|..  .|.|||  |.|..|::||:||:||||||||.||:||||.||
 Frog   219 QSRTIKSEYPDHYTNIHDPTTVGTYVYPEAYPSSSPPDIPEVILKLLQLEPDESQVKARILSCLQ 283

Human   249 QEPTKSRPDQPAAFGLLCRMADQTFISIVDWARRCMVFKELEVADQMTLLQNCWSELLVFDHIYR 313
            ||.:|.|.::...|||:|:|||||..|||:|||.|:.||||||:|||.|||||||||||||||||
 Frog   284 QEQSKGRHEKLNMFGLMCKMADQTLFSIVEWARSCIYFKELEVSDQMILLQNCWSELLVFDHIYR 348

Human   314 QVQHGKEGSILLVTGQEVELTTVATQAGSLLHSLVLRAQELVLQLLALQLDRQEFVCLKFIILFS 378
            |:||.||.|||||||||:|::.:::||||.|::|:|||||||:.|.:||:||||||||||:||||
 Frog   349 QMQHSKENSILLVTGQEIEVSAISSQAGSTLNNLILRAQELVIFLHSLQVDRQEFVCLKFLILFS 413

Human   379 LDLKFLNNHILVKDAQEKANAALLDYTLCHYPHCGDKFQQLLLCLVEVRALSMQAKEYLYHKHLG 443
            ||.|||.||.|.|.||||.:.|||:||:||||||.||::.|||.|.|:|::||||:||||||||.
 Frog   414 LDEKFLENHSLAKSAQEKVSTALLEYTMCHYPHCTDKYRSLLLRLAEIRSISMQAEEYLYHKHLS 478

Human   444 NEMPRNNLLIEMLQAKQ 460
            .|:|.||||||||.||:
 Frog   479 GEVPCNNLLIEMLHAKR 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NR5A1	NP_004950.2	NR_DBD_Lrh-1_like	13..105	CDD:143541	87/91 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	119..157		13/40 (33%)
		PHA03247	<137..216	CDD:223021	34/89 (38%)
		NR_LBD_SF-1	223..459	CDD:132755	165/236 (70%)
		Important for dimerization	230..461		163/232 (70%)
nr5a1	XP_031746117.1	NR_DBD_Lrh-1_like	41..133	CDD:143541	87/91 (96%)
		NR_LBD_SF-1	257..494	CDD:132755	165/236 (70%)