Protein Alignment ADAM2 and Kul

DIOPT Version :10

• Sequence 1: NP_001455.3
• Gene: ADAM2 / 2515
• HGNCID: 198
• Length: 735
• Species: Homo sapiens
• Sequence 2: NP_651716.1
• Gene: Kul / 43501
• FlyBaseID: FBgn0039688
• Length: 1537
• Species: Drosophila melanogaster
• Alignment Length: 508
• Identity: 117/508 - (23%)
• Similarity: 181/508 - (35%)
• Gaps: 155/508 - (30%)

Human   182 MHVIVEKQLYNHMGSDTTVVAQKVFQLIGLTNAIF--VSF-------NITIILSSLELWIDENKI 237
            :::..:...:..||||...: :.:.:.:...|.|:  ..|       |||.::..:::
  Fly   483 LYLQADHTFFQKMGSDEASI-EAITRHVQRANTIYRNTDFNNDGKPDNITFMIKRIKV------- 539

Human   238 ATTGEANELLHTFLRWKTSYLVLR--------PHD---VAFLLVYRE-KSNYVGATFQGKMCDAN 290
               ...|.:.....|:..:|.|.:        .:|   :|::..||: :...:|..:.|   |..
  Fly   540 ---HNMNAMKDPSYRFPGNYGVEKFLELFSEEDYDAFCLAYMFTYRDFEMGTLGLAWTG---DLK 598

Human   291 YAGGVVL---HPRTISLESL-------------------AVILAQLLSLSMGITYDDINKCQCSG 333
            .||||..   |.|. ||:||                   .|.||..:..:.|..:|. .:|...|
  Fly   599 NAGGVCEKNGHYRG-SLKSLNTGIVTLLNYGKHVPPAVSHVTLAHEIGHNFGSPHDP-EQCTPGG 661

Human   334 --AVCIMNPEAIHFSGVK----IFSNCSFEDFAHFI-SKQKSQ--CLHNQPRLDPFFKQQAVCGN 389
              ...||...|.  ||.|    .||.||.:.....: :|.:|.  |. .:|       |.::|||
  Fly   662 EDGNFIMFARAT--SGDKKNNNKFSTCSLKSIEPVLNAKARSMKGCF-TEP-------QSSICGN 716

Human   390 AKLEAGEECDCGTEQDCALIGETCC---------DIATCRFKAGSNC--AEGPCCENCLFMSKER 443
            ..:|.||:||||.|:||.   ::||         |...|.....:.|  ::||||.....:....
  Fly   717 GVVEPGEQCDCGWEEDCK---DSCCFPMSRQPRLDETPCTLTPHARCSPSQGPCCTTDCKLKFGD 778

Human   444 MCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWIC-IDGVCMSGDKQCTDTFGKEVEFG 507
            .||.. ..|..|.:|:|....||.:    ...|   |:.|| .:.||..||  ||.:..  :.:|
  Fly   779 KCRDD-NGCRDPSFCDGRVPQCPPS----VNKP---NKTICNKEFVCYMGD--CTGSIC--LAYG 831

Human   508 PSECYSHLNSKTDVSGNC--GISDSGYTQCEADNLQCGKLICKYVGKFLLQIPRATIIYANISGH 570
            ...|            .|  |..|.....||        |.||..|:   ..|..:
  Fly   832 LESC------------QCIPGPQDDRIKSCE--------LCCKLPGE---DSPCRS--------- 864

Human   571 LCIAVEFASDHADSQKMWIKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDKCND 623
               :.|:.....|...|:.|.||.|             :.|.||.....||.:
  Fly   865 ---SFEWNEAPFDVPDMYSKPGTPC-------------NDYNGYCDVFQKCRE 901

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADAM2	NP_001455.3	Pep_M12B_propep	26..141	CDD:460254
		Reprolysin	178..375	CDD:426256	51/244 (21%)
		DISIN	393..470	CDD:214490	27/87 (31%)
		ACR	472..609	CDD:214743	29/139 (21%)
Kul	NP_651716.1	Pep_M12B_propep	70..186	CDD:460254
		ZnMc_TACE_like	479..713	CDD:239798	53/255 (21%)
		Disintegrin	720..801	CDD:459709	26/84 (31%)