Protein Alignment ADAM2 and Meltrin

DIOPT Version :10

• Sequence 1: NP_001455.3
• Gene: ADAM2 / 2515
• HGNCID: 198
• Length: 735
• Species: Homo sapiens
• Sequence 2: NP_001027575.1
• Gene: Meltrin / 3772109
• FlyBaseID: FBgn0265140
• Length: 1407
• Species: Drosophila melanogaster
• Alignment Length: 746
• Identity: 205/746 - (27%)
• Similarity: 326/746 - (43%)
• Gaps: 124/746 - (16%)

Human    39 EGIES-QASYKIVIEGKPYTVNLMQKNFLPHN--FRVYSYSGTG-----IMKPLDQDFQNFCHYQ 95
            :|:.: |.|.....|||...|:|.:.:.|..|  |..|..:..|     ::....:...:.||||
  Fly    75 DGLHTPQISLSYTHEGKRVVVDLQRNDLLLPNSHFLRYQNASRGATPGHVVTTFTKTEVDLCHYQ 139

Human    96 GYIEGYPKSVVMVSTCTG-LRGVLQFENVSYGIEPLESSVG---FEHVIYQVKHKKADV------ 150
            |:|.|.|:|||.:|||.| |.|::.....:|.|.|.....|   .:|.:.    |:||:
  Fly   140 GHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHPHIDGRGRLQDDHYLL----KQADMHPTNAT 200

Human   151 -SLYNEKDIESRD----------------LSFKLQSVE---------PQQD-------------- 175
             ...|.:|..|.|                |..:|...|         .|.|
  Fly   201 CGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTLLRKRRQADDSSQLIRGPYNANK 265

Human   176 FAKYIEMHVIVEKQLYNHMGSDTTVVAQKVFQLIGLTNAIFVSFNITIILSSLELWIDENKIATT 240
            ::.|:|:.::|:.::|.:...:|..|.|....:..:.||::|..||.:.|..:.:|.:.|:|..:
  Fly   266 YSSYVELVIVVDNKVYKNFQENTKKVHQYCKGIANIINALYVPLNIFVALVGVVIWNESNEIEFS 330

Human   241 GEANELLHTFLRWKTSYLVL-RPHDVAFLLVYREKSNY----VGATFQGKMCDANYAGGVVL-HP 299
            .:.:..|..||.::::.||| .|:|.|.||.   |.|:    ||...:|.:|...|:|||.: |.
  Fly   331 SDGDLTLRNFLNYRSTKLVLDHPNDNAQLLT---KENFAGGVVGKALKGPICTYEYSGGVSMQHS 392

Human   300 RTISLESLAVILAQLLSLSMGITYDDINKCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFIS 364
            ...::  :|..:|..:..:.|:.: |.:.|.|....|:|...:..|..|. :|:||.:......|
  Fly   393 PNPAM--VATTMAHEMGHNFGMEH-DTSDCHCRDEKCVMAASSTSFIPVN-WSSCSIDQLTIAFS 453

Human   365 KQKSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKA-GSNCA 428
            :..:.||.|:|  :..| :...|||..:|.||:||||..:.|.   ..||:..||...: .:.||
  Fly   454 RGMNYCLRNKP--ERLF-ESPTCGNGFVEPGEQCDCGLPEHCE---NACCNAQTCMLHSKNATCA 512

Human   429 EGPCCE--NCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWICIDGVCMS 491
            .|.||:  .|........||.:..||||||||.|.|..||.:.:.:...||...|..|..|.|.|
  Fly   513 TGECCDLTTCRPKLAGSACREAENECDLPEYCTGESEYCPADVFRRDTEPCDGGQAYCFHGTCRS 577

Human   492 GDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGIS--DSGYTQCEADNLQCGKLICKYVGKFL 554
            ...||...:|...: ....||:. |::....||||.:  :..:.:||..::.||.|.|.::.:.|
  Fly   578 HSNQCRTLWGPTGD-NSEHCYNK-NTEGTRLGNCGYNRLNKTFLRCEEQHVNCGMLHCIHLNERL 640

Human   555 -LQIPRATIIYANISGH-----LC--IAVEFASDHADSQKMWIKDGTSCGSNKVCRNQRC----- 606
             ..:..|.::..:...|     .|  ..|:......|..  ...:|..||.:|:|.:|||
  Fly   641 EFGMESAAVLSHSYISHDRKIVACRTALVDLGLQTTDPG--LTPNGAKCGVDKMCVDQRCLPVDA 703

Human   607 VSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGNFPPVAIPARLP 671
            |....:|..|..| ||..|:||::.||||...:....||....   |||.|||       ||..|
  Fly   704 VRQKGMGKPCPED-CNGNGICNSRGHCHCDVGFGGESCSKAGS---GGSPDSG-------PATDP 757

Human   672 ERRYIENIYHSKPMRWPFFLFIPFFIIFCVL 702
                      :..:.:..||::.||.:..|:
  Fly   758 ----------NGSVGFKRFLYVLFFFVLPVV 778

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADAM2	NP_001455.3	Pep_M12B_propep	26..141	CDD:460254	35/113 (31%)
		Reprolysin	178..375	CDD:426256	55/202 (27%)
		DISIN	393..470	CDD:214490	32/79 (41%)
		ACR	472..609	CDD:214743	38/151 (25%)
Meltrin	NP_001027575.1	Pep_M12B_propep	53..174	CDD:460254	32/98 (33%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	54/199 (27%)
		Disintegrin	479..554	CDD:459709	32/77 (42%)
		ACR	558..701	CDD:214743	37/146 (25%)
		PHA03247	<823..1261	CDD:223021
		PHA03247	<1220..1392	CDD:223021