Protein Alignment ADAM2 and kuz

DIOPT Version :10

• Sequence 1: NP_001455.3
• Gene: ADAM2 / 2515
• HGNCID: 198
• Length: 735
• Species: Homo sapiens
• Sequence 2: NP_477187.1
• Gene: kuz / 34772
• FlyBaseID: FBgn0259984
• Length: 1238
• Species: Drosophila melanogaster
• Alignment Length: 262
• Identity: 68/262 - (25%)
• Similarity: 103/262 - (39%)
• Gaps: 68/262 - (25%)

Human   271 YREKSNYVGATFQ--------GKMCDANYAGGVVLHPRTISLESLAVILAQLLSLSMGITYDDIN 327
            |:..:..||..:|        |.:...||...|   |..:|    .:.||..:..:.|..:|...
  Fly   561 YKTYTETVGGQYQSTKRSLNTGIITFVNYNSRV---PPKVS----QLTLAHEIGHNFGSPHDYPQ 618

Human   328 KCQCSGAVCIMNPEAIHFSGV--------KIFSNCSFEDFAH----FISKQKSQCLHNQPRLDPF 380
            :|:..|    :|...|.|:..        ..||.||..:.::    .:...|..|
  Fly   619 ECRPGG----LNGNYIMFASATSGDRPNNSKFSPCSIRNISNVLDVLVGNTKRDC---------- 669

Human   381 FK--QQAVCGNAKLEAGEECDCG-TEQDCALIGETCC--------------DIATCRFKAGSNC- 427
            ||  :.|.|||..:|:||||||| .|::|.   :.||              ....|..:|.:.|
  Fly   670 FKASEGAFCGNKIVESGEECDCGFNEEECK---DKCCYPRLISEYDQSLNSSAKGCTRRAKTQCS 731

Human   428 -AEGPCC--ENCLFM--SKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWICIDG 487
             ::||||  .:|.|:  |..:.|:.. .||.....|||::|.|||..:......|.....:||.|
  Fly   732 PSQGPCCLSNSCTFVPTSYHQKCKEE-TECSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRG 795

Human   488 VC 489
            .|
  Fly   796 EC 797

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADAM2	NP_001455.3	Pep_M12B_propep	26..141	CDD:460254
		Reprolysin	178..375	CDD:426256	25/123 (20%)
		DISIN	393..470	CDD:214490	32/97 (33%)
		ACR	472..609	CDD:214743	5/18 (28%)
kuz	NP_477187.1	Pep_M12B_propep	54..149	CDD:460254
		ZnMc_TACE_like	410..677	CDD:239798	27/136 (20%)
		Disintegrin	684..776	CDD:459709	31/95 (33%)