Protein Alignment ADAM2 and mmd

DIOPT Version :10

• Sequence 1: NP_001455.3
• Gene: ADAM2 / 2515
• HGNCID: 198
• Length: 735
• Species: Homo sapiens
• Sequence 2: NP_001285311.1
• Gene: mmd / 32561
• FlyBaseID: FBgn0259110
• Length: 1484
• Species: Drosophila melanogaster
• Alignment Length: 265
• Identity: 48/265 - (18%)
• Similarity: 95/265 - (35%)
• Gaps: 84/265 - (31%)

Human   263 GLKKVTKTGRLVKALSSSIQSLPQVGQLTQLSPHSELDSRLSSTMFPSQ------DDTDSDGEEL 321
            |...:.|  ::..||.|  .||.......:...:|:.:..|...|...|      ..||:.||
  Fly   114 GTSSICK--KMAAALDS--DSLKDDASTRRSMTNSDDEDLLRQQMDVHQMIGHHHGSTDTGGE-- 172

Human   322 ALYFTEPQQLLDVFTKLEEENLSLIQN--------TQEMEETLDEL-----------------NV 361
                |.||....|..:::|    ::|:        |....|::|.:                 ::
  Fly   173 ----TPPQTADQVIEEIDE----MLQSCDFTGSMMTDRTMESVDSMYSSMRSPFPSSIQSSDADI 229

Human   362 TLKNTQIRMDKEVNLLKQWIASMMISISKEEESAAELELKARVFHFGEYQGDQQDTMLESLNHKV 426
            .|::.|..:....||.:       :|.||.....||:|...||::         :::::.|.|
  Fly   230 KLRSAQALVSNPDNLQE-------LSYSKLVTLCAEMEQLIRVYN---------ESLVDELAH-- 276

Human   427 LEVYRKCVGMQQEANLGTVQMLTVVERQLDELLENLERVPQVKIEQAEKAKERERRMRLREEKAM 491
                |..:..::|.....:.:|..:        :|..||         .|.:|:|::....:.:.
  Fly   277 ----RDELDYEKEMKNSFISLLLAI--------QNKRRV---------YANDRKRKVGKASDASQ 320

Human   492 MQKQL 496
            :.:.|
  Fly   321 LPQYL 325

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADAM2	NP_001455.3	Pep_M12B_propep	26..141	CDD:460254
		Reprolysin	178..375	CDD:426256	26/142 (18%)
		DISIN	393..470	CDD:214490	13/76 (17%)
		ACR	472..609	CDD:214743	4/25 (16%)
mmd	NP_001285311.1	Pep_M12B_propep	104..214	CDD:460254	24/113 (21%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	12/79 (15%)
		Disintegrin	488..561	CDD:459709
		ACR	566..713	CDD:214743