DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp17a1 and spo

DIOPT Version :9

Sequence 1:	NP_036885.2	Gene:	Cyp17a1 / 25146	RGDID:	2456	Length:	507	Species:	Rattus norvegicus
Sequence 2:	NP_001286943.1	Gene:	spo / 38631	FlyBaseID:	FBgn0003486	Length:	543	Species:	Drosophila melanogaster

Alignment Length:	518	Identity:	129/518 - (24%)
Similarity:	225/518 - (43%)	Gaps:	73/518 - (14%)

- Green bases have known domain annotations that are detailed below.

  Rat    20 SKTPGAKLPRSLPSLPLVGSLPFLPR-RGHMHVNFFKLQEKYGPIYSLRLGTTTTVIIGHYQLAR 83
            ::.||   ||   ..|::|:|..|.| |......|..|.::||.||||..|.|..:::.:.:|.|
  Fly    53 TQAPG---PR---PWPIIGNLHLLDRYRDSPFAGFTALAQQYGDIYSLTFGHTRCLVVNNLELIR 111

  Rat    84 EVLIKKGKEFSGRPQMVTQSLL--SDQGKGVAFADAGSSWHLHRKLV--------FSTFSLFKDG 138
            |||.:.||..||||..:....|  .::...:|..|........|.|.        ||.|.:
  Fly   112 EVLNQNGKVMSGRPDFIRYHKLFGGERSNSLALCDWSQLQQKRRNLARRHCSPREFSCFYM---- 172

  Rat   139 QKLEKLICQEA----KSLCDMMLAHDKESIDLSTPIFMSVTNIICAICFNISYEKKDPKLTAIKT 199
             |:.::.|:|.    :.|.:.::  ..|.|::...|..:..|:......::.::..|.....|..
  Fly   173 -KMSQIGCEEMEHWNRELGNQLV--PGEPINIKPLILKACANMFSQYMCSLRFDYDDVDFQQIVQ 234

  Rat   200 FTEGIVDATGDRNLVDIFPWLTIFPNKGL-EVIKGYAKVRNEVLTGIFEKCREKFD-SQSISSLT 262
            :.:.|.......:.:|..|||..|..:.| ::|...:.:|..::..|........| .:.....|
  Fly   235 YFDEIFWEINQGHPLDFLPWLYPFYQRHLNKIINWSSTIRGFIMERIIRHRELSVDLDEPDRDFT 299

  Rat   263 DILIQAKMNSDNNNSCEGRDPDVFSDRHILATVGDIFGAGIETTTTVLKWILAFLVHNPEVKKKI 327
            |.|:::.:          .|.|| |...|:..:.|..| |......::..:||::..|.::.::|
  Fly   300 DALLKSLL----------EDKDV-SRNTIIFMLEDFIG-GHSAVGNLVMLVLAYIAKNVDIGRRI 352

  Rat   328 QKEIDQYV-GFSRTPTFNDRSHLLMLEATIREVLRIRPVAPMLIPHKANVDSSIGEFTVPKDTHV 391
            |:|||..: ..:|:....|.:.:....|||.||||..  :..::||.|..|:.|..:.|.|.|.|
  Fly   353 QEEIDAIIEEENRSINLLDMNAMPYTMATIFEVLRYS--SSPIVPHVATEDTVISGYGVTKGTIV 415

  Rat   392 VVNLWALHHDENEWDQPDQFMPERFLDPTGSHLITPTQS----------------------YLPF 434
            .:|.:.|:..|..|..|.:|.|.|||:|:...  :|..|                      :|||
  Fly   416 FINNYVLNTSEKFWVNPKEFNPLRFLEPSKEQ--SPKNSKGSDSGIESDNEKLQLKRNIPHFLPF 478

  Rat   435 GAGPRSCIGEALARQELFVFTALLLQRFDLDVSDDKQLPRLEGDPKVVFL-IDPFKVKITVRQ 496
            ..|.|:|||:.|.|...|:....::||:::...:..   .::..|:.:.| .|.|.:.:|.|:
  Fly   479 SIGKRTCIGQNLVRGFGFLVVVNVMQRYNISSHNPS---TIKISPESLALPADCFPLVLTPRE 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp17a1	NP_036885.2	CYP17A1	60..490	CDD:410766	115/469 (25%)
spo	NP_001286943.1	p450	56..540	CDD:299894	129/515 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000