DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Slc2a4 and sut2

DIOPT Version :9

Sequence 1:	NP_036883.1	Gene:	Slc2a4 / 25139	RGDID:	2711	Length:	509	Species:	Rattus norvegicus
Sequence 2:	NP_524732.1	Gene:	sut2 / 44269	FlyBaseID:	FBgn0028562	Length:	491	Species:	Drosophila melanogaster

Alignment Length:	473	Identity:	165/473 - (34%)
Similarity:	246/473 - (52%)	Gaps:	21/473 - (4%)

- Green bases have known domain annotations that are detailed below.

  Rat    15 PPQQRVTG---TLVLAVFSAVLG-SLQFGYNIGVINAPQKVIEQSYNATWLGRQGPGGPDSI-PQ 74
            ||  :|.|   .|:|...:..|| ::..||..||:|||.::|::     |.........|:| ..
  Fly     9 PP--KVNGWTPLLMLICLTVTLGTTIPVGYFFGVLNAPAEIIKK-----WCQDILANEYDTIVTA 66

  Rat    75 GTLTTLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGLANAAASYEILI 139
            |.|..||...|:|:.:||:..|....::....|||..::.::||.|:.|.|.....||.|.|:|:
  Fly    67 GQLDILWTSIVSIYLIGGICGSCFSAVLCDKYGRKGCLVISSVLFVVSGILFTWCRAAKSLEMLM 131

  Rat   140 LGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILVAQVLGLESMLGTATLWPL 204
            .||||.|..|.|.....|||:.|.||:.|.|::|....:.:..|||:|||..|..:||:..|||.
  Fly   132 TGRFLGGIASALIFTAQPMYLLESAPSELSGSVGVFTCIGVTGGILLAQVATLSHLLGSERLWPY 196

  Rat   205 LLAITVLPALLQLLLLPFCPESPRYLYIIRNLEGPARKSLKRLTGWADVSDALAELKDEKRKLER 269
            .|:...|..:..|:||.:.|||||:||:.:.....:.|:|.||.|.....:...||.:.|..||.
  Fly   197 ALSFYSLLVMASLVLLWWFPESPRWLYLHKRDSAASEKALLRLRGRNTEEEVHQELLEMKATLEA 261

  Rat   270 E---RPLSLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFELAGVEQPA--YATIGA 329
            :   ...||..:|.:.....||::....|.:||||||||:|:||.||...||....|  :..:|.
  Fly   262 KSSSEVSSLCSVLRNSELWLPLLLVCSFQATQQLSGINAIFFYSLSILTNAGFSDGAATWLNLGI 326

  Rat   330 GVVNTVFTLVSVLLVERAGRRTLHLLGLAGMCGCAIL-MTVALLLLERVPS--MSYVSIVAIFGF 391
            |..|...:|:..||:.|..||.|.::. ..||..|:| |::.|..|||..|  ::|.....|..|
  Fly   327 GSFNLCTSLLGPLLIRRFPRRPLMMIS-CSMCALALLAMSLGLFFLERSESTVLTYFCAAFILTF 390

  Rat   392 VAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFSNWTCNFIVGMGFQYVADAMGPYVFLLFAVL 456
            :..|::|.|||.:||.:||....|||.||::....:|..||:|||.|..:......:.|:....:
  Fly   391 ILGFQLGLGPIAYFIGSELLEDSPRPVAMSMGSLFSWIGNFLVGMCFPLLQSVWSSFAFIPCMCV 455

  Rat   457 LLGFFIFTFLRVPETRGR 474
            .:...:.|:..:||||||
  Fly   456 CIYCLLLTWRYLPETRGR 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc2a4	NP_036883.1	Interaction with SRFBP1. /evidence=ECO:0000250\|UniProtKB:P14672	7..13
		Sugar_tr	27..483	CDD:278511	159/458 (35%)
		MFS	78..447	CDD:119392	136/376 (36%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	298..304		5/5 (100%)
		Dileucine internalization motif. /evidence=ECO:0000255	489..490
sut2	NP_524732.1	Sugar_tr	23..473	CDD:278511	157/455 (35%)
sut2	NP_524732.1	MFS	76..466	CDD:119392	136/390 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337960
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0569
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	321	0.113	Inparanoid score	I2429
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D291809at33208
OrthoFinder	1	1.000	-	-		FOG0000120
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23503
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.900