DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slc2a4 and CG6484

DIOPT Version :9

Sequence 1:	NP_036883.1	Gene:	Slc2a4 / 25139	RGDID:	2711	Length:	509	Species:	Rattus norvegicus
Sequence 2:	NP_611234.1	Gene:	CG6484 / 36994	FlyBaseID:	FBgn0034247	Length:	465	Species:	Drosophila melanogaster

Alignment Length:	473	Identity:	158/473 - (33%)
Similarity:	241/473 - (50%)	Gaps:	55/473 - (11%)

- Green bases have known domain annotations that are detailed below.

  Rat    26 LAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNATWLGRQGPGGPDSIPQ-GTLTTLWALSVAIFS 89
            :|..||..|:|..|.:||..:..:.:|  :.|..:      |.|.|..| |.:::|..|...:..
  Fly    11 IAGLSASFGALCMGASIGWSSPVENMI--TVNTEY------GFPISSSQFGWVSSLLTLGATVIC 67

  Rat    90 VGGMISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGLANAAASYEILILGRFLIGAYSGLTSG 154
            :.       ||....|:||:..|||.....::|..||..|.   :..:|..|||::|...|....
  Fly    68 IP-------IGFAIDWIGRRPTMLALIPPYMVGWVLMLFAK---NVTMLYFGRFILGMCGGAFCV 122

  Rat   155 LVPMYVGEIAPTHLRGALGTLNQLAIVIGILVAQVLGLESMLGTATLWPLL---LAITVLPALLQ 216
            ..|||..||..|.|||.:|:..||.||.|:|...::|        ...|||   :...:||.:..
  Fly   123 TAPMYCTEITATALRGTIGSFFQLLIVSGVLYGYLVG--------AFLPLLTINILCAILPVIFA 179

  Rat   217 LLLLPFCPESPRYLYIIRNLEGPARKSLKRLTGW-ADVSDALAELKDEKRKLERERPLSLLQLLG 280
            ::.. |.||||.|| .::.....|.|:|:.|.|. ||:.|.|.|:.:|.:|......:::|..|
  Fly   180 IIHF-FMPESPVYL-AMKGRNDDAAKALQWLRGKDADIDDELKEILEESQKQIDMPQVNILSSL- 241

  Rat   281 SRTHRQPLI-----IAVVLQLSQQLSGINAVFYYSTSIFELAGVE-QPAYATIGAGVVNTVFTLV 339
                |:|::     |||:||:.||.:|||||.:||.||||..|.: ..:.||:..||.....|||
  Fly   242 ----RRPIVLKGLGIAVLLQVFQQWTGINAVLFYSASIFEDTGSDISGSDATLIIGVTQVTSTLV 302

  Rat   340 SVLLVERAGRRTLHLLGLAGMCGCAILMTVALLLLERVP----SMSYVSIVAIFGFVAFFEIGPG 400
            :|.::::||||.|.|:....|.....||.|...|.|..|    :..::.|.:|..|:.||.||.|
  Fly   303 AVAIIDKAGRRILLLISGVLMAVSTALMGVYFQLKENDPASMDNFGWLPISSICIFIIFFSIGFG 367

  Rat   401 PIPWFIVAELFSQGPRPAAMAVAGFSNWTCNFIVGMGFQYVADAMGP----YVFLLFAVLLLGFF 461
            |:||.::|||||:..:..|.::||.|||...|:|.:.|..:..::||    ::|...||:.   |
  Fly   368 PVPWLVMAELFSEDVKSVAGSIAGTSNWLSAFVVTLLFPILKSSIGPGPTFWIFTAIAVIA---F 429

  Rat   462 IFTFLRVPETRGRTFDQI 479
            .::...||||:|:|..:|
  Fly   430 FYSLFFVPETKGKTIIEI 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc2a4	NP_036883.1	Interaction with SRFBP1. /evidence=ECO:0000250\|UniProtKB:P14672	7..13
		Sugar_tr	27..483	CDD:278511	158/472 (33%)
		MFS	78..447	CDD:119392	130/382 (34%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	298..304		3/5 (60%)
		Dileucine internalization motif. /evidence=ECO:0000255	489..490
CG6484	NP_611234.1	Sugar_tr	14..451	CDD:278511	157/470 (33%)
CG6484	NP_611234.1	MFS	14..436	CDD:119392	150/457 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337701
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840