Protein Alignment Myo5b and ck

DIOPT Version :10

• Sequence 1: XP_008770307.1
• Gene: Myo5b / 25132
• RGDID: 621347
• Length: 1854
• Species: Rattus norvegicus
• Sequence 2: NP_523571.1
• Gene: ck / 34882
• FlyBaseID: FBgn0000317
• Length: 2167
• Species: Drosophila melanogaster
• Alignment Length: 2219
• Identity: 564/2219 - (25%)
• Similarity: 876/2219 - (39%)
• Gaps: 641/2219 - (28%)

  Rat    78 GENDLTALSHLHEPAVLHNLKVRFLESNHIYTYCGIVLVAINPYEQLPIYGQDVIYAYSGQNMGD 142
            |..|:.:|..|||..:|.||.:|:.| |.||||.|.:|||:|||:.||||..|.|..|..:.:|:
  Fly    64 GVEDMISLGDLHEAGILRNLLIRYKE-NLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGE 127

  Rat   143 MDPHIFAVAEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATVGGSASDTNIEEKVLAS 207
            :.|||||:.:.||..|.|..::|.|::|||||||||.|.|..::|.|.:.|..|  .||:::|.:
  Fly   128 LPPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKHS--WIEQQILEA 190

  Rat   208 SPIMEAIGNAKTTRNDNSSRFGKYIEIGFDKKYHIIGANMRTYLLEKSRVVFQADDERNYHIFYQ 272
            :||:||.|||||.||||||||||||:|.|.....|.||.:..|||||||:|.|...|||||:||.
  Fly   191 NPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYC 255

  Rat   273 LCAAASLPEFKELALTCAEDFFYTAHGGNTTIEGVDDAEDFEKTRQALTLLGVRESHQISIFKII 337
            :.|..|..|...|.|..|.|:.|...|.:.|.||.|||.:|...|.|:.:|...:.....|.|::
  Fly   256 ILAGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKLL 320

  Rat   338 ASILHLGSVEIQAE-RDGDSCSISPQDEHLSNFCRLLGIEHSQMEHWLCHRKLVTTSETYVKTMS 401
            |::||.|:::.:|. .|....:..|:..::.....|||:....:...|..|.|....||.|.|:|
  Fly   321 AALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVSTLS 385

  Rat   402 LQQVVNARNALAKHIYAQLFSWIVEHINKAL----QTSLKQHSFIGVLDIYGFETFEINSFEQFC 462
            ..|.|:.|:|..|.||.::|..||..||.|:    .||   .:.||||||:|||.|:.|||||||
  Fly   386 RDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTS---RNAIGVLDIFGFENFDQNSFEQFC 447

  Rat   463 INYANEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDFYDNQPCIDLIEAK-LGILDLLDEECKVPK 526
            ||||||.|||.|..|:||||||||..|.|.|..|:|.|||..:|||..| |.|:.|:|||.:.||
  Fly   448 INYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALIDEEARFPK 512

  Rat   527 GTDQNWAQKLYERHSNSQHFQKPRMS-NTAFIVIHFADKVEYLSDGFLEKNRDTVYEEQINILKA 590
            ||||....||::.|.:.:::.||:.. ||:|.:.|||..|.|.:.|||:|||||...:.::::..
  Fly   513 GTDQTMLAKLHKTHGSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHLVSQ 577

  Rat   591 SKFPLVADLFRDDKDSVPATNTAKSRSSSKINVRSSRPLMKAPNKEHKKSVGYQFRTSLNLLMET 655
            |....:..:|..|.:                        |.|..::...::..|||.||:.||:|
  Fly   578 STNKFLRQIFAQDIE------------------------MGAETRKRTPTLSTQFRKSLDALMKT 618

  Rat   656 LNATTPHYVRCIKPNDEKLPFHFDPKRAVQQLRACGVLETIRISAAGYPSRWTYHDFFNRYRVLM 720
            |::..|.::||||||:.|.|..||.....:|||..|::|||||..||||.|..:.:|..|||.|:
  Fly   619 LSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLI 683

  Rat   721 KKRELANTTD----KKNICKSVLESLIKDPDKFQFGRTKIFFRAGQVAYLEKLRADKFREATIMI 781
            .....|:.||    ...||..||     ....:|.|.||:|.:.....:||:.|........:::
  Fly   684 PGVPPAHRTDCQAATSRICAVVL-----GKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILIL 743

  Rat   782 QKTVRGWLQRVKYRRLRAATLTLQRFCRGYLARRLTEHLR----RTRAAI---VFQKQYRMLK-- 837
            |:::|||:.|.::.|||||.:|:|||.:||..|:...::|    |.:|.|   |...::|.|:
  Fly   744 QRSIRGWVYRRRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGH 808

  Rat   838 ------------ARRAYCRVRRAAVIIQSYTRAMCVRRSYRQVLTEHK--ATIIQ---------- 878
                        .||.|.....|.:.|||:.|.|...|.||::..|||  |.::|
  Fly   809 IVGLQAHARGYLVRREYGHKMWAVIKIQSHVRRMIAMRRYRKLRLEHKQFAEVLQLRKLEEQELL 873

  Rat   879 ----KYARGWMARRHFQRQRDAAIVIQCAFRRLKARQALKALKIEARSAEHLKRLNVGME--NKV 937
                |:||. :|.:|:   ||       ....|:.|:..:.|       |:.:|:.|.|.  |..
  Fly   874 HRGNKHARE-IAEQHY---RD-------RLHELERREIQEQL-------ENRRRVEVNMNIINDA 920

  Rat   938 VQLQRK-IDD------------------------------------QN----------------- 948
            .:.|.: :||                                    ||
  Fly   921 ARKQEEPVDDGKLVEAMFDFLPDSSSDAPTPHGGRETSVFNDLPHAQNVNQDDIIAPIHISEDEE 985

  Rat   949 --KEFK------------------------------TLSEQLSA--------------------- 960
              .|||                              |..:||:|
  Fly   986 DLSEFKFQKFAATYFQGNVNHQYAKKALKHPLLPLHTQGDQLAAQALWITILRFTGDMPEPKYHT 1050

  Rat   961 -----VTSTHAMEVEKLKKELARYQQNQEA-----DPSLQLQEEVQSLRTELQKAHSERRVLEDT 1015
                 .||..:.....|.:...|.::.|||     ||...|:::.:|:|.:|.....:|:
  Fly  1051 MDRMDTTSVMSKVTATLGRNFIRSKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRK----- 1110

  Rat  1016 HNRENGELRKRVADLEHE----------------------------NALLKDE-----KEHLNNQ 1047
             |:...::|:|:.|.|:.                            .|.|:||     .:.|.|.
  Fly  1111 -NKLGEDVRRRLQDDEYTADSYQSWLQSRPTSNLEKLHFIIGHGILRAELRDEIYCQICKQLTNN 1174

  Rat  1048 ILRQSKAES-------------SQSSVEENLLIKKELEEERSRYQNLVKEYSQLEQRYENLRDEQ 1099
            .|:.|.|..             |:..|.   .::..:.|....|....:|  :|::.:.|
  Fly  1175 PLKSSHARGWILLSLCVGCFAPSEKFVN---YLRAFIREGPPGYAPYCEE--RLKRTFNN----- 1229

  Rat  1100 QTPGHRKNPSNQSSLES--------------DSNYPSISTSEIGDTEDALQQVEEIGIEKAAMDM 1150
               |.|..|.:...|::              |.|..::.........:...|:.:....|.....
  Fly  1230 ---GTRNQPPSWLELQATKSKKPIMLPITFMDGNTKTLLADSATTARELCNQLSDKISLKDQFGF 1291

  Rat  1151 TVFLKLQKRVRELEQERKKLQVQLEKEQQDSKKVQVEQQNNGLDV---------------DQDA- 1199
            ::::.|..:|..|......:...:.:.:|.:|:...:::|....:               ||.|
  Fly  1292 SLYIALFDKVSSLGSGGDHVMDAISQCEQYAKEQGAQERNAPWRLFFRKEIFAPWHEPTHDQVAT 1356

  Rat  1200 DIAYNSLKRQELESENKKLKNDLNELRKAVADQAMQDNSTHSSPDS-YSLLLNQLK---LANEEL 1260
            ::.|..:.|.....|.:..|.:  :|....|.|...:.||..|.:. ::||.|.:.   |:..:.
  Fly  1357 NLIYQQVVRGVKFGEYRCDKEE--DLAMIAAQQYFIEYSTDMSMERLFTLLPNFIPDFCLSGVDK 1419

  Rat  1261 EVRKEEVLILRTQIMNADQR-RLSGKNMEPNI--NARTSWP-----------NSEKHVDQEDAIE 1311
            .:.:...|:|:....:...: :::...::.:|  .|:..||           ||..::.:.|.|.
  Fly  1420 AIERWAALVLQAYKKSYYVKDKIAPLKIKEDIVSYAKYKWPLLFSRFYEAYRNSGPNLPKNDVII 1484

  Rat  1312 A--YHGVCQTNSQTEDWGYLNEDGELGLAYQGLKQVARLLEAQLQAQNLKHEEEVEHLKAQVEAM 1374
            |  :.||           |:.:|.|         ||  |||...        .|:..:.:|
  Fly  1485 AVNWTGV-----------YVVDDQE---------QV--LLELSF--------PEITAVSSQ---- 1515

  Rat  1375 KEEMDKQQQTFCQTLLLSPEAQVEFGVQQEISRLTNENLDFKELVEKLEKNEKKLKKQLKIYMKK 1439
                 |..:.|.||..||.....||..|...:.      |.::||.......||..|    |:..
  Fly  1516 -----KTNKVFTQTFSLSTVRGEEFTFQSPNAE------DIRDLVVYFLDGLKKRSK----YVIA 1565

  Rat  1440 VQDLEAAQALAQSDRRHHELTRQVTVQRKEKDFQGMLEYHKEDEALLIRNLVTDLKPQMLSGTVP 1504
            :||                       .|...|....|.:.|.|  |:|      |:.:....:|.
  Fly  1566 LQD-----------------------YRAPSDGTSFLSFFKGD--LII------LEDESCGESVL 1599

  Rat  1505 ----CL------------PAYILYMCIRHADYTNDDLKVHSL--------LSSTING-------- 1537
                |:            ||..:|:....:....|.|.:.::        ||...||
  Fly  1600 NNGWCIGRCDRSQERGDFPAETVYVLPTLSKPPQDILALFNIEEAHHGRRLSMASNGGAVEPRDR 1664

  Rat  1538 -------------------IKKVL---KKHNED----------------FEMTSFWLSNTCRLLH 1564
                               :.|.|   .|.:|:                .:....:....|....
  Fly  1665 PHTLMEYALDHFRLPPKRTMSKTLTLSSKRSEELWRYSRDPIKAPLLRKLQSKEEFAEEACFAFA 1729

  Rat  1565 CLKQYSGDEGFMTQNTAKQNEHCLKNFDLTEYRQVLSDLSIQIYQQLIK---------------- 1613
            .:.:|.||  ..::.....||.....||.....::|.|   :||.||:|
  Fly  1730 AILKYMGD--LPSKRPRMGNEITDHIFDGPLKHEILRD---EIYCQLMKQLTDNRNRMSEERGWE 1789

  Rat  1614 ----------IAEGLLQPMIVSAM-----LENESIQGLSGVRPTGYRKRSSSMVDGENSYCLEAI 1663
                      .::|||:.:::...     :..:|:..|......|.||.....|:      :|||
  Fly  1790 LMWLATGLFACSQGLLKELLLFLRTRRHPISQDSMHRLQKTIRHGQRKYPPHQVE------VEAI 1848

  Rat  1664 -IRQMNFFHTVLCDQGLDPEIILQVFKQLFYMINAVTLNNLLLRKDACS---------WSTGMQL 1718
             .:....||.|......|               .|..:::....||.|:         .|.|..|
  Fly  1849 QHKTTQIFHKVYFPDDTD---------------EAFEVDSSTRAKDFCNNISQRLSLRTSEGFSL 1898

  Rat  1719 RYNIS-----------------QLEEWLR-------GKNLQQSGAVQTMEPL------------- 1746
            ...|:                 .|.:|::       |.|.|.:..|..|:.|
  Fly  1899 FVKIADKVISVPEGDFFFDFVRHLTDWIKKARPIRDGANPQFTYQVFFMKKLWTNTVPGKDRNAD 1963

  Rat  1747 ---------------------IQAAQLLQLK-----KKTQEDAEAICSLCTSLSTQQIVKI---- 1781
                                 .:||:|..|.     .:.:::.:||..:...|....|:||
  Fly  1964 LIFHYHQELPKLLRGYHKCSREEAAKLAALVFRVRFGENKQELQAIPQMLRELIPSDIMKIQSTS 2028

  Rat  1782 ---LNLYTPLNE----FEERVTVSFIRTIQ------------AQLQERSDPQQLLLD-SKHMFPV 1826
               .::....|:    ..|...|:|::.:.            .|..|.:.|:.||:. :||...:
  Fly  2029 EWKRSIVASYNQDGGMTSEDAKVAFLKIVYRWPTFGSAFFEVKQTTEPNYPEMLLIAINKHGVSL 2093

  Rat  1827 LFPFNPSAL 1835
            :.|.....|
  Fly  2094 IHPVTKDIL 2102

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo5b	XP_008770307.1	MYSc_Myo5	91..759	CDD:276831	287/678 (42%)
		IQ	773..795	CDD:197470	5/21 (24%)
		IQ	821..842	CDD:197470	9/41 (22%)
		IQ	871..891	CDD:197470	10/35 (29%)
		SMC_prok_B	906..>1268	CDD:274008	86/560 (15%)
		Myo5b_CBD	1480..1851	CDD:271261	90/554 (16%)
ck	NP_523571.1	MYSc_Myo7	77..721	CDD:276832	287/678 (42%)
		MyTH4	<1138..1245	CDD:214535	20/119 (17%)
		FERM1_F1_Myosin-VII	1249..1347	CDD:340612	10/97 (10%)
		B41	1251..1467	CDD:214604	33/217 (15%)
		FERM_C1_MyoVII	1461..1559	CDD:270019	30/142 (21%)
		SH3	1560..1624	CDD:473055	16/98 (16%)
		MyTH4	1701..1849	CDD:214535	26/158 (16%)
		FERM2_F1_Myosin-VII	1854..1951	CDD:340613	19/111 (17%)
		B41	1856..2068	CDD:214604	34/226 (15%)
		FERM_C2_MyoVII	2064..2159	CDD:270020	9/39 (23%)