DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo5b and ck

DIOPT Version :9

Sequence 1:XP_008770307.1 Gene:Myo5b / 25132 RGDID:621347 Length:1854 Species:Rattus norvegicus
Sequence 2:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster


Alignment Length:2219 Identity:564/2219 - (25%)
Similarity:876/2219 - (39%) Gaps:641/2219 - (28%)


- Green bases have known domain annotations that are detailed below.


  Rat    78 GENDLTALSHLHEPAVLHNLKVRFLESNHIYTYCGIVLVAINPYEQLPIYGQDVIYAYSGQNMGD 142
            |..|:.:|..|||..:|.||.:|:.| |.||||.|.:|||:|||:.||||..|.|..|..:.:|:
  Fly    64 GVEDMISLGDLHEAGILRNLLIRYKE-NLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGE 127

  Rat   143 MDPHIFAVAEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATVGGSASDTNIEEKVLAS 207
            :.|||||:.:.||..|.|..::|.|::|||||||||.|.|..::|.|.:.|..|  .||:::|.:
  Fly   128 LPPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKHS--WIEQQILEA 190

  Rat   208 SPIMEAIGNAKTTRNDNSSRFGKYIEIGFDKKYHIIGANMRTYLLEKSRVVFQADDERNYHIFYQ 272
            :||:||.|||||.||||||||||||:|.|.....|.||.:..|||||||:|.|...|||||:||.
  Fly   191 NPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYC 255

  Rat   273 LCAAASLPEFKELALTCAEDFFYTAHGGNTTIEGVDDAEDFEKTRQALTLLGVRESHQISIFKII 337
            :.|..|..|...|.|..|.|:.|...|.:.|.||.|||.:|...|.|:.:|...:.....|.|::
  Fly   256 ILAGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKLL 320

  Rat   338 ASILHLGSVEIQAE-RDGDSCSISPQDEHLSNFCRLLGIEHSQMEHWLCHRKLVTTSETYVKTMS 401
            |::||.|:::.:|. .|....:..|:..::.....|||:....:...|..|.|....||.|.|:|
  Fly   321 AALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVSTLS 385

  Rat   402 LQQVVNARNALAKHIYAQLFSWIVEHINKAL----QTSLKQHSFIGVLDIYGFETFEINSFEQFC 462
            ..|.|:.|:|..|.||.::|..||..||.|:    .||   .:.||||||:|||.|:.|||||||
  Fly   386 RDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTS---RNAIGVLDIFGFENFDQNSFEQFC 447

  Rat   463 INYANEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDFYDNQPCIDLIEAK-LGILDLLDEECKVPK 526
            ||||||.|||.|..|:||||||||..|.|.|..|:|.|||..:|||..| |.|:.|:|||.:.||
  Fly   448 INYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALIDEEARFPK 512

  Rat   527 GTDQNWAQKLYERHSNSQHFQKPRMS-NTAFIVIHFADKVEYLSDGFLEKNRDTVYEEQINILKA 590
            ||||....||::.|.:.:::.||:.. ||:|.:.|||..|.|.:.|||:|||||...:.::::..
  Fly   513 GTDQTMLAKLHKTHGSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHLVSQ 577

  Rat   591 SKFPLVADLFRDDKDSVPATNTAKSRSSSKINVRSSRPLMKAPNKEHKKSVGYQFRTSLNLLMET 655
            |....:..:|..|.:                        |.|..::...::..|||.||:.||:|
  Fly   578 STNKFLRQIFAQDIE------------------------MGAETRKRTPTLSTQFRKSLDALMKT 618

  Rat   656 LNATTPHYVRCIKPNDEKLPFHFDPKRAVQQLRACGVLETIRISAAGYPSRWTYHDFFNRYRVLM 720
            |::..|.::||||||:.|.|..||.....:|||..|::|||||..||||.|..:.:|..|||.|:
  Fly   619 LSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLI 683

  Rat   721 KKRELANTTD----KKNICKSVLESLIKDPDKFQFGRTKIFFRAGQVAYLEKLRADKFREATIMI 781
            .....|:.||    ...||..||     ....:|.|.||:|.:.....:||:.|........:::
  Fly   684 PGVPPAHRTDCQAATSRICAVVL-----GKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILIL 743

  Rat   782 QKTVRGWLQRVKYRRLRAATLTLQRFCRGYLARRLTEHLR----RTRAAI---VFQKQYRMLK-- 837
            |:::|||:.|.::.|||||.:|:|||.:||..|:...::|    |.:|.|   |...::|.|:  
  Fly   744 QRSIRGWVYRRRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGH 808

  Rat   838 ------------ARRAYCRVRRAAVIIQSYTRAMCVRRSYRQVLTEHK--ATIIQ---------- 878
                        .||.|.....|.:.|||:.|.|...|.||::..|||  |.::|          
  Fly   809 IVGLQAHARGYLVRREYGHKMWAVIKIQSHVRRMIAMRRYRKLRLEHKQFAEVLQLRKLEEQELL 873

  Rat   879 ----KYARGWMARRHFQRQRDAAIVIQCAFRRLKARQALKALKIEARSAEHLKRLNVGME--NKV 937
                |:||. :|.:|:   ||       ....|:.|:..:.|       |:.:|:.|.|.  |..
  Fly   874 HRGNKHARE-IAEQHY---RD-------RLHELERREIQEQL-------ENRRRVEVNMNIINDA 920

  Rat   938 VQLQRK-IDD------------------------------------QN----------------- 948
            .:.|.: :||                                    ||                 
  Fly   921 ARKQEEPVDDGKLVEAMFDFLPDSSSDAPTPHGGRETSVFNDLPHAQNVNQDDIIAPIHISEDEE 985

  Rat   949 --KEFK------------------------------TLSEQLSA--------------------- 960
              .|||                              |..:||:|                     
  Fly   986 DLSEFKFQKFAATYFQGNVNHQYAKKALKHPLLPLHTQGDQLAAQALWITILRFTGDMPEPKYHT 1050

  Rat   961 -----VTSTHAMEVEKLKKELARYQQNQEA-----DPSLQLQEEVQSLRTELQKAHSERRVLEDT 1015
                 .||..:.....|.:...|.::.|||     ||...|:::.:|:|.:|.....:|:     
  Fly  1051 MDRMDTTSVMSKVTATLGRNFIRSKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRK----- 1110

  Rat  1016 HNRENGELRKRVADLEHE----------------------------NALLKDE-----KEHLNNQ 1047
             |:...::|:|:.|.|:.                            .|.|:||     .:.|.|.
  Fly  1111 -NKLGEDVRRRLQDDEYTADSYQSWLQSRPTSNLEKLHFIIGHGILRAELRDEIYCQICKQLTNN 1174

  Rat  1048 ILRQSKAES-------------SQSSVEENLLIKKELEEERSRYQNLVKEYSQLEQRYENLRDEQ 1099
            .|:.|.|..             |:..|.   .::..:.|....|....:|  :|::.:.|     
  Fly  1175 PLKSSHARGWILLSLCVGCFAPSEKFVN---YLRAFIREGPPGYAPYCEE--RLKRTFNN----- 1229

  Rat  1100 QTPGHRKNPSNQSSLES--------------DSNYPSISTSEIGDTEDALQQVEEIGIEKAAMDM 1150
               |.|..|.:...|::              |.|..::.........:...|:.:....|.....
  Fly  1230 ---GTRNQPPSWLELQATKSKKPIMLPITFMDGNTKTLLADSATTARELCNQLSDKISLKDQFGF 1291

  Rat  1151 TVFLKLQKRVRELEQERKKLQVQLEKEQQDSKKVQVEQQNNGLDV---------------DQDA- 1199
            ::::.|..:|..|......:...:.:.:|.:|:...:::|....:               ||.| 
  Fly  1292 SLYIALFDKVSSLGSGGDHVMDAISQCEQYAKEQGAQERNAPWRLFFRKEIFAPWHEPTHDQVAT 1356

  Rat  1200 DIAYNSLKRQELESENKKLKNDLNELRKAVADQAMQDNSTHSSPDS-YSLLLNQLK---LANEEL 1260
            ::.|..:.|.....|.:..|.:  :|....|.|...:.||..|.:. ::||.|.:.   |:..:.
  Fly  1357 NLIYQQVVRGVKFGEYRCDKEE--DLAMIAAQQYFIEYSTDMSMERLFTLLPNFIPDFCLSGVDK 1419

  Rat  1261 EVRKEEVLILRTQIMNADQR-RLSGKNMEPNI--NARTSWP-----------NSEKHVDQEDAIE 1311
            .:.:...|:|:....:...: :::...::.:|  .|:..||           ||..::.:.|.|.
  Fly  1420 AIERWAALVLQAYKKSYYVKDKIAPLKIKEDIVSYAKYKWPLLFSRFYEAYRNSGPNLPKNDVII 1484

  Rat  1312 A--YHGVCQTNSQTEDWGYLNEDGELGLAYQGLKQVARLLEAQLQAQNLKHEEEVEHLKAQVEAM 1374
            |  :.||           |:.:|.|         ||  |||...        .|:..:.:|    
  Fly  1485 AVNWTGV-----------YVVDDQE---------QV--LLELSF--------PEITAVSSQ---- 1515

  Rat  1375 KEEMDKQQQTFCQTLLLSPEAQVEFGVQQEISRLTNENLDFKELVEKLEKNEKKLKKQLKIYMKK 1439
                 |..:.|.||..||.....||..|...:.      |.::||.......||..|    |:..
  Fly  1516 -----KTNKVFTQTFSLSTVRGEEFTFQSPNAE------DIRDLVVYFLDGLKKRSK----YVIA 1565

  Rat  1440 VQDLEAAQALAQSDRRHHELTRQVTVQRKEKDFQGMLEYHKEDEALLIRNLVTDLKPQMLSGTVP 1504
            :||                       .|...|....|.:.|.|  |:|      |:.:....:|.
  Fly  1566 LQD-----------------------YRAPSDGTSFLSFFKGD--LII------LEDESCGESVL 1599

  Rat  1505 ----CL------------PAYILYMCIRHADYTNDDLKVHSL--------LSSTING-------- 1537
                |:            ||..:|:....:....|.|.:.::        ||...||        
  Fly  1600 NNGWCIGRCDRSQERGDFPAETVYVLPTLSKPPQDILALFNIEEAHHGRRLSMASNGGAVEPRDR 1664

  Rat  1538 -------------------IKKVL---KKHNED----------------FEMTSFWLSNTCRLLH 1564
                               :.|.|   .|.:|:                .:....:....|....
  Fly  1665 PHTLMEYALDHFRLPPKRTMSKTLTLSSKRSEELWRYSRDPIKAPLLRKLQSKEEFAEEACFAFA 1729

  Rat  1565 CLKQYSGDEGFMTQNTAKQNEHCLKNFDLTEYRQVLSDLSIQIYQQLIK---------------- 1613
            .:.:|.||  ..::.....||.....||.....::|.|   :||.||:|                
  Fly  1730 AILKYMGD--LPSKRPRMGNEITDHIFDGPLKHEILRD---EIYCQLMKQLTDNRNRMSEERGWE 1789

  Rat  1614 ----------IAEGLLQPMIVSAM-----LENESIQGLSGVRPTGYRKRSSSMVDGENSYCLEAI 1663
                      .::|||:.:::...     :..:|:..|......|.||.....|:      :|||
  Fly  1790 LMWLATGLFACSQGLLKELLLFLRTRRHPISQDSMHRLQKTIRHGQRKYPPHQVE------VEAI 1848

  Rat  1664 -IRQMNFFHTVLCDQGLDPEIILQVFKQLFYMINAVTLNNLLLRKDACS---------WSTGMQL 1718
             .:....||.|......|               .|..:::....||.|:         .|.|..|
  Fly  1849 QHKTTQIFHKVYFPDDTD---------------EAFEVDSSTRAKDFCNNISQRLSLRTSEGFSL 1898

  Rat  1719 RYNIS-----------------QLEEWLR-------GKNLQQSGAVQTMEPL------------- 1746
            ...|:                 .|.:|::       |.|.|.:..|..|:.|             
  Fly  1899 FVKIADKVISVPEGDFFFDFVRHLTDWIKKARPIRDGANPQFTYQVFFMKKLWTNTVPGKDRNAD 1963

  Rat  1747 ---------------------IQAAQLLQLK-----KKTQEDAEAICSLCTSLSTQQIVKI---- 1781
                                 .:||:|..|.     .:.:::.:||..:...|....|:||    
  Fly  1964 LIFHYHQELPKLLRGYHKCSREEAAKLAALVFRVRFGENKQELQAIPQMLRELIPSDIMKIQSTS 2028

  Rat  1782 ---LNLYTPLNE----FEERVTVSFIRTIQ------------AQLQERSDPQQLLLD-SKHMFPV 1826
               .::....|:    ..|...|:|::.:.            .|..|.:.|:.||:. :||...:
  Fly  2029 EWKRSIVASYNQDGGMTSEDAKVAFLKIVYRWPTFGSAFFEVKQTTEPNYPEMLLIAINKHGVSL 2093

  Rat  1827 LFPFNPSAL 1835
            :.|.....|
  Fly  2094 IHPVTKDIL 2102

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo5bXP_008770307.1 MYSc 72..770 CDD:214580 295/702 (42%)
MYSc_Myo5 91..759 CDD:276831 287/678 (42%)
IQ 871..891 CDD:197470 10/35 (29%)
DUF1690 910..1002 CDD:285231 31/210 (15%)
Rab5-bind 919..1179 CDD:286404 63/438 (14%)
RILP-like <979..1069 CDD:304877 26/140 (19%)
Uso1_p115_C 1155..1267 CDD:282695 23/131 (18%)
GBP_C <1340..1416 CDD:303769 17/75 (23%)
coiled coil 1385..1396 CDD:293879 5/10 (50%)
coiled coil 1405..1416 CDD:293879 1/10 (10%)
Myo5b_CBD 1480..1851 CDD:271261 90/554 (16%)
ckNP_001285949.1 MYSc 64..733 CDD:214580 295/703 (42%)
MYSc_Myo7 77..721 CDD:276832 287/678 (42%)
MyTH4 <1138..1245 CDD:214535 20/119 (17%)
B41 1251..1467 CDD:214604 33/217 (15%)
FERM_B-lobe 1355..1439 CDD:271216 17/85 (20%)
FERM_C1_MyoVII 1461..1559 CDD:270019 30/142 (21%)
SH3 1560..1624 CDD:302595 16/98 (16%)
MyTH4 1701..1849 CDD:214535 26/158 (16%)
B41 1856..2068 CDD:214604 34/226 (15%)
FERM_M 1966..2068 CDD:278785 14/101 (14%)
FERM_C2_MyoVII 2064..2159 CDD:270020 9/39 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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