DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stat5b and Stat92E

DIOPT Version :9

Sequence 1:	XP_038941184.1	Gene:	Stat5b / 25126	RGDID:	3774	Length:	795	Species:	Rattus norvegicus
Sequence 2:	NP_001262760.1	Gene:	Stat92E / 42428	FlyBaseID:	FBgn0016917	Length:	818	Species:	Drosophila melanogaster

Alignment Length:	803	Identity:	268/803 - (33%)
Similarity:	386/803 - (48%)	Gaps:	156/803 - (19%)

- Green bases have known domain annotations that are detailed below.

  Rat    43 AFPHRGATLFIPVDRKSSLENIKATQLLEGLVQELQKKAEHQV----GEDGFLLKIKLGHYATQL 103
            |...|...|...:.|.|::|  ..|.|..||.:|||...|..|    |:     .:.|..|  .:
  Fly    79 ALKFRVVELCALIQRISAVE--LYTHLRSGLQKELQLVTEKSVAATAGQ-----SMPLNPY--NM 134

  Rat   104 QNT-----YDRCPMELV----RCIRHILYNEQRLVREANNG-SSPAGSL----ADAMSQKHLQIN 154
            .||     |...|.:|:    .|...::.....:....|.| :|||..:    .:....:| ||.
  Fly   135 NNTPMVTGYMVDPSDLLAVSNSCNPPVVQGIGPIHNVQNTGIASPALGMVTPKVELYEVQH-QIM 198

  Rat   155 QTFEELRLITQDTESELKKLQQTQEYFIIQYQESLRIQAQFAQLAQLNPQERMSRETALQQKQVS 219
            |:..|.    .:..:.||.|.|...|                   .||.....:.|.|
  Fly   199 QSLNEF----GNCANALKLLAQNYSY-------------------MLNSTSSPNAEAA------- 233

  Rat   220 LETWLQREAQTLQQYRVELAEKHQKTLQLLRK-------QQTIILDDELIQWKRRQQLAGNGGP- 276
                          ||..:.||....|.:.|.       .:.:|  .||..|:.:|..||||.|
  Fly   234 --------------YRSLIDEKAAIVLTMRRSFMYYESLHEMVI--HELKNWRHQQAQAGNGAPF 282

  Rat   277 PEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEML--------AEVNATITDII 333
            .|||||.:|...|.|...|          .|:.      ..|:|::        .|:...:..:.
  Fly   283 NEGSLDDIQRCFEMLESFI----------AHML------AAVKELMRVRLVTEEPELTHLLEQVQ 331

  Rat   334 SA---LVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNE 395
            :|   ||.|.||::||||||:||.|:|||:||.|:|.:|.:|.|||.|:..|:||.|::..: ..
  Fly   332 NAQKNLVCSAFIVDKQPPQVMKTNTRFAASVRWLIGSQLGIHNNPPTVECIIMSEIQSQRFV-TR 395

  Rat   396 NTRND-------YSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRSDRRGAESVTEEKFTILF 453
            ||:.|       .||||.|....|||.|.....||.||||.||:|||::::|.|||.:|||.:.|
  Fly   396 NTQMDNSSLSGQSSGEIQNASSTMEYQQNNHVFSASFRNMQLKKIKRAEKKGTESVMDEKFALFF 460

  Rat   454 DSQFSVGGNELVFQVKTLSLPVVVIVHGSQDNNATATVLWDNAFAEPGRVPFAVPDKVLWPQLCE 518
            .:..:|  |:...:|.||||||||||||:|:..:.||:.|||||||..|.||.:.|:|.|.||..
  Fly   461 YTTTTV--NDFQIRVWTLSLPVVVIVHGNQEPQSWATITWDNAFAEIVRDPFMITDRVTWAQLSV 523

  Rat   519 ALNMKFKAEVQSNRGLTKENLVFLAQKLFNSSSNHLEDYNSMSVSWSQFNRENLPGRNYTFWQWF 583
            |||:||.:  .:.|.||.:||.||.:||       ..:..|..::|:||.:|.:|.|::|||:||
  Fly   524 ALNIKFGS--CTGRSLTIDNLDFLYEKL-------QREERSEYITWNQFCKEPMPDRSFTFWEWF 579

  Rat   584 DGVMEVLKKHLKPHWNDGAILGFVNKQQAH-DLLINKPD-GTFLLRFSDSEIGGITIAWKFDSQE 646
            ..:|::.|.|:...|..|.|:||:||.:|. |||.:... |||||||||||:||:|||  :.::.
  Fly   580 FAIMKLTKDHMLGMWKAGCIMGFINKTKAQTDLLRSVYGIGTFLLRFSDSELGGVTIA--YVNEN 642

  Rat   647 RMFWNLMPFTTRDFSIRSLADRLGDLNYLIYVFP-DR-----PKD----EVYSKYYTPVPCEPAT 701
            .:...|.|:|.|||.:.:||||:.||:.|.::.| ||     .:|    |.|||...|   ||..
  Fly   643 GLVTMLAPWTARDFQVLNLADRIRDLDVLCWLHPSDRNASPVKRDVAFGEFYSKRQEP---EPLV 704

  Rat   702 AKAADGYVKPQIKQVVPEFVNASADAGSGATYMDQAPSPV--VCPQAHYNMYPQNPDSVLDTDGD 764
            .....||||..:...|..  |....:.||..:..|....:  :.||:....|  :|..:.::|.
  Fly   705 LDPVTGYVKSTLHVHVCR--NGENGSTSGTPHHAQESMQLGNISPQSGITFY--SPARLEESDS- 764

  Rat   765 FDLEDTMDVARRVEELLG-RPMD 786
             |..:|.:...|:  ::| :|.|
  Fly   765 -DASETAEALERI--VIGAQPND 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stat5b	XP_038941184.1	STAT_int	<65..133	CDD:397135	18/80 (23%)
		STAT5_CCD	148..339	CDD:341080	46/209 (22%)
		STAT5_DBD	341..498	CDD:341087	81/163 (50%)
		SH2_STAT5b	582..726	CDD:198283	62/155 (40%)
Stat92E	NP_001262760.1	STAT_int	2..119	CDD:214942	14/41 (34%)
		STAT_alpha	151..340	CDD:279369	52/251 (21%)
		STAT_bind	342..587	CDD:280939	119/256 (46%)
		SH2_STAT_family	578..696	CDD:198175	51/119 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340136
Domainoid	1	1.000	123	1.000	Domainoid score	I5459
eggNOG	1	0.900	-	-		E1_KOG3667
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	312	1.000	Inparanoid score	I2506
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D166575at33208
OrthoFinder	1	1.000	-	-		FOG0001643
OrthoInspector	1	1.000	-	-		otm44930
orthoMCL	1	0.900	-	-		OOG6_104819
Panther	1	1.100	-	-	LDO	PTHR11801
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1200
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.760