Protein Alignment Scnn1a and ppk26

DIOPT Version :10

• Sequence 1: NP_113736.1
• Gene: Scnn1a / 25122
• RGDID: 3639
• Length: 699
• Species: Rattus norvegicus
• Sequence 2: NP_648125.3
• Gene: ppk26 / 38835
• FlyBaseID: FBgn0035785
• Length: 597
• Species: Drosophila melanogaster
• Alignment Length: 628
• Identity: 122/628 - (19%)
• Similarity: 215/628 - (34%)
• Gaps: 215/628 - (34%)

  Rat    88 FCNNTTIHGAIRLVCSKHNRMKTAFW-AVLWLCTFGMMYWQFAL-LFEEYLSYPVSLNINLNSD- 149
            :|:.|||||...|...|...::..|| :||.|..|..:  :..| :::::.:.||.::....|.
  Fly    74 YCDYTTIHGIRYLGEKKRPLLERLFWISVLVLSVFTCV--KLTLNIWDKWNNNPVIVSFAEKSTP 136

  Rat   150 --KLVFPAVTVCTLNPYRYTEIKEELEELDRITEQTLFDLYKYNSSYTRQAGARRRSSRDLLGAF 212
              ::.|||||||       .|.|            |..:::.:..||
  Fly   137 VWQIPFPAVTVC-------PETK------------TRREIFNFTDSY------------------ 164

  Rat   213 PHPLQRLRTPPPPYSGRTARSGSSSVRDNNPQVDRKDWKIGF-----QLCNQNKSDCFYQTYSSG 272
                         :..|..:|..|.:      ||..|.:.|.     |:|..:..|     .:.|
  Fly   165 -------------HQVRDFQSNVSGI------VDLSDKQKGLYGAVSQVCEPHLHD-----VTLG 205

  Rat   273 VDAVREWYRFHYINILSRLSDTSPALEEEALGNFIFTCRFNQAP--CNQANYSKFHHPMY--GNC 333
            ....|.      :.|:..|::.||..::..|     .|::..:|  |:..    ||..:.  |.|
  Fly   206 NKTRRG------MEIIDALTEVSPHFDDTYL-----NCKWRNSPVKCSDI----FHKFVTEDGVC 255

  Rat   334 YTFNDKNNSNLWMS---------------SM-----------------------PGVNNGLSLTL 360
            ::||..:.:.::.:               ||                       ||...||.|.:
  Fly   256 FSFNSLSPAEIFRAEGIIPDFIFREENRLSMDWNVEDGYSASADTSPYPNRVLGPGARAGLYLFM 320

  Rat   361 RTEQNDFIPLL-STVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKEALDSLGGNYGDCTE 424
            ...:.||..:. ..|.|.::::|...:.|.:....|.:....|..||:|.:.:.:..|
  Fly   321 GGAEIDFDDMCRGPVQGFKILLHTPGDVAQVSKQYFRIPFDQEVLISIRPKIITTSDG------- 378

  Rat   425 NGSDVPVKNLYPSK----------------YTQQVCIHSCFQENMIKKCGCAYIFYPKPKGVEFC 473
                  :|:..|::                |:|..|...|.....:.||||.....|:...:..|
  Fly   379 ------LKHYEPNRRQCYFQKERELRYFNIYSQSNCELECLANFTLTKCGCVKFSMPRNVNMPVC 437

  Rat   474 DYRKQSSWGYCYYKLQ---------------GAFSLDSLGCFSKCRKPCSVINYKLSAGYSRWPS 523
            ......    ||.:.:               |..:.....|  .|...|:.|.|:        ..
  Fly   438 GDASLK----CYNQAEDELLLREFTQGLVNAGENTRGETEC--NCLPSCTSIAYE--------AE 488

  Rat   524 VKSQDWIFEMLSLQNNYTIN----------NKRNG--VAKLNIFFKELNYKTNSESPSVTMVSLL 576
            :...|:.::.:       ||          :||.|  :::::|||||..:.|:..|........|
  Fly   489 ISQADFDYKTV-------INTDSPEGKEEQSKRQGMKMSRVSIFFKEAQFLTSRRSELYGTTDFL 546

  Rat   577 SNLGSQWSLWFGSSVLSVVEMAELIFDLLVITLLMLLRRFRSR 619
            :|.|....|:.|.|:||:||       |:....:.|:...|.|
  Fly   547 ANCGGLLGLFMGVSMLSIVE-------LIYFCTVRLISNLRMR 582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Scnn1a	NP_113736.1	ENaC	80..677	CDD:273304	122/628 (19%)
ppk26	NP_648125.3	ASC	74..570	CDD:459966	119/614 (19%)