DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pcsk2 and Fur2

DIOPT Version :9

Sequence 1:NP_036878.1 Gene:Pcsk2 / 25121 RGDID:3273 Length:637 Species:Rattus norvegicus
Sequence 2:NP_727963.1 Gene:Fur2 / 32604 FlyBaseID:FBgn0004598 Length:1682 Species:Drosophila melanogaster


Alignment Length:639 Identity:288/639 - (45%)
Similarity:375/639 - (58%) Gaps:75/639 - (11%)


- Green bases have known domain annotations that are detailed below.


  Rat    21 FASAERPVFTNHFLVELHKDGEEEARQVAAEHGFGVR-KLPFAEGLYHFYHNGLAKAKRRRSLHH 84
            |:..|..::||.|.|.: ..|::.|..:|.:|||..| ::...:..|.|.|:.::|...|.|..|
  Fly   231 FSIPEEAIYTNEFAVNI-PAGKQMADVIATKHGFINRGQIGSLDNYYLFQHHHVSKRSLRSSRKH 294

  Rat    85 KRQLERDPRIKMALQQEGFDRKKRG---------------------------------------- 109
            :..|:.:..:|...||....|:||.                                        
  Fly   295 QGALKSENEVKWMQQQHEKVRRKRDGPYQDLPTYSPYNLLRQHGGYVVDPNPHLSFSPESISLAS 359

  Rat   110 ------YRDINEIDINMNDPLFTKQWYLF--NTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMD 166
                  |||::...| ..||||.:||||.  |.|..|   |||:||..||:.|||||||.:.|:|
  Fly   360 HSQRMEYRDVSSHFI-FPDPLFKEQWYLVSKNGGAKD---GLDMNVGPAWQKGYTGKGVVVSILD 420

  Rat   167 DGIDYLHPDLAYNYNSDASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAASNNICGVGVAYN 231
            |||...|||||.||:.:||:|.:.||..|.|:  |:..|.|||||||||:|.|.||.||||||||
  Fly   421 DGIQTNHPDLAQNYDPEASFDINGNDSDPTPQ--DNGDNKHGTRCAGEVAAVAFNNFCGVGVAYN 483

  Rat   232 SKVAGIRMLDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGR 296
            :.:.|:||||.. :.|::||.::|..|..||||||||||.|:|.|||||..|..:|...||..||
  Fly   484 ASIGGVRMLDGK-VNDVVEAQALSLNPSHIDIYSASWGPEDDGSTVDGPGPLARRAFIYGVTSGR 547

  Rat   297 GGKGSIYVWASGDGGSY-DDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKR 360
            .|||||:|||||:||.| |.||||||.:|::|:||:||...|....|.|.||||||:|:|:|...
  Fly   548 QGKGSIFVWASGNGGRYTDSCNCDGYTNSIFTLSISSATQAGFKPWYLEECSSTLATTYSSGTPG 612

  Rat   361 NPEAGVATTDLYGN------CTLRHSGTSAAAPEAAGVFALALEANVDLTWRDMQHLTVLTSKRN 419
            : :..|||.|:.|:      ||:.|:||||:||.|||:.|||||||.:|||||||:|.|.||:..
  Fly   613 H-DKSVATVDMDGSLRPDHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVYTSRPA 676

  Rat   420 QLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQNPEKIPPTGKL 484
            .|..| :.|..|||..:::|.||||::||||||.:|:.|.:||.:..|  .|.:|.|.....|..
  Fly   677 PLEKE-NGWTLNGVKRKYSHKFGYGLMDAGAMVSLAEQWTSVPPQHIC--KSRENNEDRKIDGAY 738

  Rat   485 VLTLQT----NACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSK 545
            ..||.|    |.|.|..|.||||||||..||:....||:|.|.:||||||.|.||..||| |..|
  Fly   739 GSTLSTHMDVNGCAGTINEVRYLEHVQCRITLRFFPRGNLRILLTSPMGTTSTLLFERPR-DIVK 802

  Rat   546 VGFDKWPFMTTHTWGEDARGTWTLEL--GFVGSAPQKGLLKEWTLMLHGTQSAP 597
            ..||.|||::.|.|||.|.|.|||::  |......|.|:|.:|.|:.:||.:.|
  Fly   803 SNFDDWPFLSVHFWGEKAEGRWTLQVINGGRRRVNQPGILSKWQLIFYGTSTQP 856

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pcsk2NP_036878.1 S8_pro-domain 32..108 CDD:293079 21/76 (28%)
Peptidases_S8_Protein_convertases_Kexins_Fur in-like 121..417 CDD:173789 172/304 (57%)
Peptidase_S8 157..434 CDD:278510 157/283 (55%)
P_proprotein 503..590 CDD:279782 45/88 (51%)
Fur2NP_727963.1 S8_pro-domain 242..318 CDD:293079 21/76 (28%)
Peptidases_S8_Protein_convertases_Kexins_Fur in-like 375..674 CDD:173789 172/305 (56%)
Peptidase_S8 411..700 CDD:278510 161/293 (55%)
P_proprotein 761..849 CDD:279782 45/88 (51%)
Furin-like 966..1126 CDD:279142
FU 970..1013 CDD:238021
FU 1017..1067 CDD:238021
FU 1063..1106 CDD:214589
GF_recep_IV 1068..1232 CDD:291509
FU 1116..1163 CDD:238021
FU 1211..1255 CDD:214589
FU 1259..1301 CDD:214589
FU 1304..1348 CDD:214589
FU 1356..1403 CDD:238021
FU 1401..1444 CDD:214589
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1404
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D311719at33208
OrthoFinder 1 1.000 - - FOG0000204
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.820

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