Protein Alignment Chrna5 and nAChRalpha6

DIOPT Version :9

• Sequence 1: NP_058774.2
• Gene: Chrna5 / 25102
• RGDID: 2347
• Length: 467
• Species: Rattus norvegicus
• Sequence 2: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Alignment Length: 505
• Identity: 178/505 - (35%)
• Similarity: 267/505 - (52%)
• Gaps: 93/505 - (18%)

  Rat    41 SSAAKHEDSLFRDLFEDYERWVRPVEHLSDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWID 105
            |....||..|...|...|....|||.:.|:.:::||||.:.|::|||||||::|||.||..||.|
  Fly    24 SCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILTTNAWLNLEWND 88

  Rat   106 VKLRWNPDDYGGIKIIRVPSDSLWIPDIVLFDNADGRFEGA-STKTVVRYNGTVTWTQPANYKSS 169
            ..||||..:|||:|.:|:..:.||.||::::::||..|:|. .|..||::||:..:..|..:||:
  Fly    89 YNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGSCLYVPPGIFKST 153

  Rat   170 CTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQD-VDRTDFFDNGEWEIMSAMGSKGNRTDS 233
            |.||:|:||||.|:|.||||||||||:|:|::|..:| .|.:||..||||.:::..|.|.....:
  Fly   154 CKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFITNGEWYLLAMPGKKNTIVYA 218

  Rat   234 CCWYPY--ITYSFVIKRLPLFYTLFLIIPCIGLSFLTVVVFYLPSNEGEKISLCTSVLVSLTVFL 296
            ||..||  ||::..|:|..|:|...||:||:.:|.:.::.|.||.:.|||::|..::|:||||||
  Fly   219 CCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTLGVTILLSLTVFL 283

  Rat   297 LVIEEIIPSSSKVIPLI-----------------------------GEYLVFTMIFVTLSIMVTV 332
            .::.|.:|::|..:|||                             |.|....|..|..|:::||
  Fly   284 NLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMFMVASSVVLTV 348

  Rat   333 FAINIHHRSSSTHNAMAPWVRKIFLHKLPKLLCMRSHADRYFTQR--------EEAE-------- 381
            ..:|.|||::..|. |.||::.:||..||.:|.| ....|..|::        :|.|
  Fly   349 VVLNYHHRTADIHE-MPPWIKSVFLQWLPWILRM-GRPGRKITRKTILLSNRMKELELKERSSKS 411

  Rat   382 ------------------------SGAGPKSRNTLE---AALDC-----------IRYITRHVVK 408
                                    |.|......|:|   .|:.|           :::||..:.|
  Fly   412 LLANVLDIDDDFRHTISGSQTAIGSSASFGRPTTVEEHHTAIGCNHKDLHLILKELQFITARMRK 476

  Rat   409 ENDVREVVEDWKFIAQVLDRMFLWTFLLVSIIGTLGLFVPVIYKWANIIV 458
            .:|..|::.||||.|.|:||..|..|.|.:||.|    |.|:....:|||
  Fly   477 ADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIAT----VTVLLSAPHIIV 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Chrna5	NP_058774.2	LIC	41..448	CDD:273305	173/493 (35%)
		Neur_chan_LBD	47..250	CDD:280998	94/206 (46%)
		Neur_chan_memb	257..446	CDD:280999	75/271 (28%)
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	175/498 (35%)
		LGIC_ECD_nAChR	55..236	CDD:349798	85/180 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	64	1.000	Domainoid score	I9885
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910