Protein Alignment Th and ple

DIOPT Version :10

• Sequence 1: NP_036872.1
• Gene: Th / 25085
• RGDID: 3853
• Length: 498
• Species: Rattus norvegicus
• Sequence 2: NP_476898.1
• Gene: ple / 38746
• FlyBaseID: FBgn0005626
• Length: 579
• Species: Drosophila melanogaster
• Alignment Length: 501
• Identity: 243/501 - (48%)
• Similarity: 336/501 - (67%)
• Gaps: 35/501 - (6%)

  Rat     7 PSPQPKGFRRAVSEQDAKQAEAVTSPRFIGRRQSLIED-ARKEREAAAAAAAAAVASSEPGNPLE 70
            |..:...|.....||...|::   .|.  |.:|....| ...|.|...|.||:..:.:|......
  Fly   100 PVEEDVEFESVEQEQSESQSQ---EPE--GNQQPTKNDYGLTEDEILLANAASESSDAEAAMQSA 159

  Rat    71 AVVFEERDGNAVLNLLFSLRGTKPSSLSRAVKVFETFEAKIHHLETRPAQRPLAGSPHLEYFVRF 135
            |:|...::|              .|||.|.:|..|||...:.|:|:|  |..:.|..| :..::.
  Fly   160 ALVVRLKEG--------------ISSLGRILKAIETFHGTVQHVESR--QSRVEGVDH-DVLIKL 207

  Rat   136 EVPSGDLAALLSSVRR---------VSDDVRSAREDKVPWFPRKVSELDKCHHLVTKFDPDLDLD 191
            ::..|:|..|:.|:|:         ::|:..:.   |.||||:..||||.|:||:||::||||::
  Fly   208 DMTRGNLLQLIRSLRQSGSFSSMNLMADNNLNV---KAPWFPKHASELDNCNHLMTKYEPDLDMN 269

  Rat   192 HPGFSDQVYRQRRKLIAEIAFQYKHGEPIPHVEYTAEEIATWKEVYVTLKGLYATHACREHLEGF 256
            ||||:|:|||||||.||||||.||:|:|||.::|:..|:.||:.|:.|::.|...|||.|:...|
  Fly   270 HPGFADKVYRQRRKEIAEIAFAYKYGDPIPFIDYSDVEVKTWRSVFKTVQDLAPKHACAEYRAAF 334

  Rat   257 QLLERYCGYREDSIPQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSP 321
            |.|:....:.|..:|||:::|.||::.|||.|||.||||:|||||||||||:||.|||:||.:||
  Fly   335 QKLQDEQIFVETRLPQLQEMSDFLRKNTGFSLRPAAGLLTARDFLASLAFRIFQSTQYVRHVNSP 399

  Rat   322 MHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTVYWFTVEFGLCKQNGEL 386
            .|:||||..||||||:|:|||.:||||||:||||||||||||||||||||||||||||||::|::
  Fly   400 YHTPEPDSIHELLGHMPLLADPSFAQFSQEIGLASLGASDEEIEKLSTVYWFTVEFGLCKEHGQI 464

  Rat   387 KAYGAGLLSSYGELLHSLSEEPEVRAFDPDTAAVQPYQDQTYQPVYFVSESFNDAKDKLRNYASR 451
            ||||||||||||||||::|::.|.|||:|.:.||||||||.|||:|:|:|||.|||||.|.:.|.
  Fly   465 KAYGAGLLSSYGELLHAISDKCEHRAFEPASTAVQPYQDQEYQPIYYVAESFEDAKDKFRRWVST 529

  Rat   452 IQRPFSVKFDPYTLAIDVLDSPHTIQRSLEGVQDELHTLAHALSAI 497
            :.|||.|:|:|:|..::||||...::..:..:..|:..|.:|:|.:
  Fly   530 MSRPFEVRFNPHTERVEVLDSVDKLETLVHQMNTEILHLTNAISKL 575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Th	NP_036872.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31		5/23 (22%)
		TOH_N	2..26	CDD:403668	4/18 (22%)
		ACT_TH	38..158	CDD:153202	31/129 (24%)
		Biopterin_H	165..495	CDD:459776	203/329 (62%)
ple	NP_476898.1	Tyr_3_monoox	130..576	CDD:130336	235/466 (50%)