DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Th and ple

DIOPT Version :9

Sequence 1:XP_038957248.1 Gene:Th / 25085 RGDID:3853 Length:507 Species:Rattus norvegicus
Sequence 2:NP_001286955.1 Gene:ple / 38746 FlyBaseID:FBgn0005626 Length:579 Species:Drosophila melanogaster


Alignment Length:510 Identity:244/510 - (47%)
Similarity:337/510 - (66%) Gaps:44/510 - (8%)


- Green bases have known domain annotations that are detailed below.


  Rat     7 PSPQPKGFRRAVSEQDAKQAEAVTVRRICCHPESPRFIGRRQSLIED-ARKEREAAAAAAAAAVA 70
            |..:...|.....||...|::         .||     |.:|....| ...|.|...|.||:..:
  Fly   100 PVEEDVEFESVEQEQSESQSQ---------EPE-----GNQQPTKNDYGLTEDEILLANAASESS 150

  Rat    71 SSEPGNPLEAVVFEERDGNAVLNLLFSLRGTKPSSLSRAVKVFETFEAKIHHLETRPAQRPLAGS 135
            .:|......|:|...::|              .|||.|.:|..|||...:.|:|:|  |..:.|.
  Fly   151 DAEAAMQSAALVVRLKEG--------------ISSLGRILKAIETFHGTVQHVESR--QSRVEGV 199

  Rat   136 PHLEYFVRFEVPSGDLAALLSSVRR---------VSDDVRSAREDKVPWFPRKVSELDKCHHLVT 191
            .| :..::.::..|:|..|:.|:|:         ::|:..:.   |.||||:..||||.|:||:|
  Fly   200 DH-DVLIKLDMTRGNLLQLIRSLRQSGSFSSMNLMADNNLNV---KAPWFPKHASELDNCNHLMT 260

  Rat   192 KFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYKHGEPIPHVEYTAEEIATWKEVYVTLKGLYATH 256
            |::||||::||||:|:|||||||.||||||.||:|:|||.::|:..|:.||:.|:.|::.|...|
  Fly   261 KYEPDLDMNHPGFADKVYRQRRKEIAEIAFAYKYGDPIPFIDYSDVEVKTWRSVFKTVQDLAPKH 325

  Rat   257 ACREHLEGFQLLERYCGYREDSIPQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCT 321
            ||.|:...||.|:....:.|..:|||:::|.||::.|||.|||.||||:|||||||||||:||.|
  Fly   326 ACAEYRAAFQKLQDEQIFVETRLPQLQEMSDFLRKNTGFSLRPAAGLLTARDFLASLAFRIFQST 390

  Rat   322 QYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTVYWFTVEF 386
            ||:||.:||.|:||||..||||||:|:|||.:||||||:||||||||||||||||||||||||||
  Fly   391 QYVRHVNSPYHTPEPDSIHELLGHMPLLADPSFAQFSQEIGLASLGASDEEIEKLSTVYWFTVEF 455

  Rat   387 GLCKQNGELKAYGAGLLSSYGELLHSLSEEPEVRAFDPDTAAVQPYQDQTYQPVYFVSESFNDAK 451
            ||||::|::||||||||||||||||::|::.|.|||:|.:.||||||||.|||:|:|:|||.|||
  Fly   456 GLCKEHGQIKAYGAGLLSSYGELLHAISDKCEHRAFEPASTAVQPYQDQEYQPIYYVAESFEDAK 520

  Rat   452 DKLRNYASRIQRPFSVKFDPYTLAIDVLDSPHTIQRSLEGVQDELHTLAHALSAI 506
            ||.|.:.|.:.|||.|:|:|:|..::||||...::..:..:..|:..|.:|:|.:
  Fly   521 DKFRRWVSTMSRPFEVRFNPHTERVEVLDSVDKLETLVHQMNTEILHLTNAISKL 575

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ThXP_038957248.1 TOH_N 2..26 CDD:403668 4/18 (22%)
ACT_TH 47..167 CDD:153202 31/129 (24%)
Biopterin_H 174..504 CDD:395280 203/329 (62%)
pleNP_001286955.1 Tyr_3_monoox 130..576 CDD:130336 235/466 (50%)
ACT 130..234 CDD:298841 29/120 (24%)
Biopterin_H 243..573 CDD:278766 203/329 (62%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166341387
Domainoid 1 1.000 440 1.000 Domainoid score I531
eggNOG 1 0.900 - - E1_COG3186
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H307
Inparanoid 1 1.050 463 1.000 Inparanoid score I1487
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D361696at33208
OrthoFinder 1 1.000 - - FOG0000587
OrthoInspector 1 1.000 - - oto95666
orthoMCL 1 0.900 - - OOG6_108343
Panther 1 1.100 - - O PTHR11473
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X3954
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1514.760

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