DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bru2 and WHI3

DIOPT Version :9

Sequence 1:	NP_001036356.1	Gene:	bru2 / 250811	FlyBaseID:	FBgn0262475	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	NP_014202.1	Gene:	WHI3 / 855524	SGDID:	S000005141	Length:	661	Species:	Saccharomyces cerevisiae

Alignment Length:	533	Identity:	120/533 - (22%)
Similarity:	177/533 - (33%)	Gaps:	144/533 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 TAVASAAAATTMLATAPVAHVANG----NNSNSSAGSSSNSNSSSNNHSLYSNNNLNTGNNSQQQ 94
            |.|......|..|.:.|.:.:.|.    |.|||  |....|..|..:...:|:...|....||||
Yeast   187 TTVEIIDDTTKNLVSFPSSAIFNDTSRLNKSNS--GMKRPSLLSQRSRFSFSDPFSNDSPLSQQQ 249

  Fly    95 QQQQQQHPQILPVKYEYLEN---------------LTSSGATSG----------AIAATTTFTGA 134
            .|||||.|| .|.::...::               |:|.|...|          ::.:|...:..
Yeast   250 SQQQQQQPQ-QPQQHSTQKHSPQQCNQQQVNSSIPLSSQGQVIGLHSNHSHQDLSVESTIQTSDI 313

  Fly   135 AKSFHPYLRPTGSGSNSNNSIAALSTTTAATAAKMST------TLFETLLHNQINSSPIALP--A 191
            .|||  .||   ..:..|..|...|...::....|||      ||.........:.|...||  |
Yeast   314 GKSF--LLR---DNTEINEKIWGTSGIPSSINGYMSTPQPSTPTLEWGNTSASQHGSSFFLPSAA 373

  Fly   192 ATAIAAISAAATA---ATATPGTAATAAAAAAAAPSTQ--------LNSSINSRTSLGDQGGAIV 245
            :||||..::..:|   |::..|.:...|..|.:|.|.|        :|:|:.|..||
Yeast   374 STAIAPTNSNTSANANASSNNGASNNGANQALSASSQQPMMQIGNTINTSLTSSNSL-------- 430

  Fly   246 VVTPAPPVAAPPTGGPNRNQSPTRDCSVKMELMESTSPDSIKDQPDADNIKMFVGQIPKTWDETR 310
                      ||.|                 ||.|.| ..|.:..:..::.:    .|:..:...
Yeast   431 ----------PPYG-----------------LMSSQS-QHISNMVNTSDMNI----TPQKQNRFM 463

  Fly   311 LRQMFEQFGPVHTLNV----------------LRDKVTSISRGCCFVTYYTRKAALRAQD--ALH 357
            .:...|...||:..|.                ..:..||:|      :..|..|::...|  .|.
Yeast   464 QQPQPEHMYPVNQSNTPQKVPPARLSSSRNSHKNNSTTSLS------SNITGSASISQADLSLLA 522

  Fly   358 NIKTLDGMHHPIQMKPADSENRNERKLFVGMLNKKYTEADVRQLFTGHGTIEECTVLRDQA---G 419
            .|        |....||| :|.....|:||.|....||.::||||:|.......:......   |
Yeast   523 RI--------PPPANPAD-QNPPCNTLYVGNLPSDATEQELRQLFSGQEGFRRLSFRNKNTTSNG 578

  Fly   420 QSKG-CAFVTFATKQNAIGAIKALHQSQTMEGCSAPLVVKFADTQKEKDQKKMQQIHAFCGINTP 483
            .|.| ..||.|.....|..|:..|:..|...           .|...|...::.......|:..|
Yeast   579 HSHGPMCFVEFDDVSFATRALAELYGRQLPR-----------STVSSKGGIRLSFSKNPLGVRGP 632

  Fly   484 SGATAGAATPTIN 496
            :....|:..|..|
Yeast   633 NSRRGGSGNPNPN 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bru2	NP_001036356.1	RRM1_CELF1_2_Bruno	294..375	CDD:241075	15/98 (15%)
		RRM2_Bruno_like	381..461	CDD:241080	21/83 (25%)
		RRM_SF	801..892	CDD:302621
WHI3	NP_014202.1	RRM	450..>648	CDD:223796	46/226 (20%)
WHI3	NP_014202.1	RRM_scw1_like	536..624	CDD:409691	23/98 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343563
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930