Protein Alignment bru2 and Celf6

DIOPT Version :10

• Sequence 1: NP_001036356.1
• Gene: bru2 / 250811
• FlyBaseID: FBgn0262475
• Length: 893
• Species: Drosophila melanogaster
• Sequence 2: NP_001400450.1
• Gene: Celf6 / 76183
• MGIID: 1923433
• Length: 481
• Species: Mus musculus
• Alignment Length: 646
• Identity: 241/646 - (37%)
• Similarity: 307/646 - (47%)
• Gaps: 170/646 - (26%)

  Fly   250 APPVAAPPTGGPNRNQSPTRDCSVKMELMESTSPDSIKDQPDADNIKMFVGQIPKTWDETRLRQM 314
            ||..:|||.|...|....|.|....   |...:|.......|.|.||:||||||:..||..|:.:
Mouse     4 APGGSAPPAGPSPRLAFSTADSGGG---MSGLNPGPAVPMKDHDAIKLFVGQIPRGLDEQDLKPL 65

  Fly   315 FEQFGPVHTLNVLRDKVTSISRGCCFVTYYTRKAALRAQDALHNIKTLDGMHHPIQMKPADSENR 379
            ||:||.::.|.||:|::|.:.:||.|:||..|.:||:||.|||..|||.||:.|||:|||.||.|
Mouse    66 FEEFGRIYELTVLKDRLTGLHKGCAFLTYCARDSALKAQSALHEQKTLPGMNRPIQVKPAASEGR 130

  Fly   380 NE-RKLFVGMLNKKYTEADVRQLFTGHGTIEECTVLRDQAGQSKGCAFVTFATKQNAIGAIKALH 443
            .| ||||||||.|:..|.|||:||...|.||||||||...|.|||||||.|.::..|..||:.||
Mouse   131 GEDRKLFVGMLGKQQGEEDVRRLFQPFGHIEECTVLRSPDGTSKGCAFVKFGSQGEAQAAIQGLH 195

  Fly   444 QSQTMEGCSAPLVVKFADTQKEKDQKKMQQIHAFCGINTPSGATAGAATPTINAATALIAAPPSA 508
            .|:||.|.|:.||||.|||.:|:..::|||:                                 |
Mouse   196 GSRTMTGASSSLVVKLADTDRERALRRMQQM---------------------------------A 227

  Fly   509 GRTNPSMAAALAAVPQVQQAGSAATAPTTLVPLNSTTALSASLTPNLLATNAAHQGAAAAAAYLG 573
            |                 |.|:...||   :||.:..|.:.::..:..|..||.||..     ||
Mouse   228 G-----------------QLGAFHPAP---LPLGACGAYTTAILQHQAALLAAAQGPG-----LG 267

  Fly   574 ADPAAAAHLQLYQQLHGYGLSPAHYLPGLNFHHPPENSAHHSQHSPGIGGASAASLSAAAATAAS 638
            ...|.||.:                                 ||.......:|..|.|||.|:..
Mouse   268 QVAAVAAQM---------------------------------QHVAAFSLVAAPLLPAAANTSPG 299

  Fly   639 NPLGGAPPPTPTPTSSAGHAAGAGLLAAPSMSMQNLVALLATPTAHHQLSLHHSSSSSGHNNGNS 703
            ....||.|..|.|....|..:                   .||.::.|     ..|.:.:|||.|
Mouse   300 GNGPGALPGLPAPMGVNGFGS-------------------LTPQSNGQ-----PGSDTLYNNGVS 340

  Fly   704 SATSGLHNQRLTYAAAPPPPPISTTYNMPQLIGHTATPTQPGGSSQSLTFNALWPPNAADPYSSS 768
                              |.|..:                               |:.|||...:
Mouse   341 ------------------PYPAKS-------------------------------PSVADPLQQA 356

  Fly   769 LSGLTN-GAAYGAASQPVTTSALQAAAAGVTGKQIEGPDGSNLFIYHLPQEFIDTDLASTFLPFG 832
            .:|:.: .|||.:|..|.:|:..|..:| :..:|.|||:|.|||||||||||.|.:|..||||||
Mouse   357 YAGIHHYAAAYPSAYAPASTAFSQQPSA-LPQQQREGPEGCNLFIYHLPQEFGDAELIQTFLPFG 420

  Fly   833 NVLSAKVFIDKQTNLSKCFGFVSYDNPHSANAAIQAMHGFQIGSKRLKVQLKRSKDAAKPY 893
            .|:|||||:|:.||.||||||||:|||.||..|||||:|||||.|||||||||.|||.:||
Mouse   421 AVVSAKVFVDRATNQSKCFGFVSFDNPTSAQTAIQAMNGFQIGMKRLKVQLKRPKDANRPY 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bru2	NP_001036356.1	RRM_SF	294..375	CDD:473069	43/80 (54%)
		RRM_SF	381..461	CDD:473069	48/80 (60%)
		RRM_SF	801..892	CDD:473069	68/90 (76%)
Celf6	NP_001400450.1	RRM1_CELF3_4_5_6	41..127	CDD:410041	46/85 (54%)
		PABP-1234	<48..390	CDD:130689	156/506 (31%)
		RRM2_CELF3_4_5_6	133..213	CDD:410043	47/79 (59%)
		RRM3_CELF3_4_5_6	392..470	CDD:241083	58/77 (75%)