Protein Alignment bru2 and CELF5

DIOPT Version :9

• Sequence 1: NP_001036356.1
• Gene: bru2 / 250811
• FlyBaseID: FBgn0262475
• Length: 893
• Species: Drosophila melanogaster
• Sequence 2: NP_068757.2
• Gene: CELF5 / 60680
• HGNCID: 14058
• Length: 485
• Species: Homo sapiens
• Alignment Length: 668
• Identity: 247/668 - (36%)
• Similarity: 305/668 - (45%)
• Gaps: 218/668 - (32%)

  Fly   246 VVTPAP-PVAA---PPTGGPNRNQSPTRDCSVKMELMESTSPDSIKDQPDADNIKMFVGQIPKTW 306
            ::.|.| ||.:   .|.||                     .||.:|   |.|.||:||||||:..
Human    16 LLQPRPSPVGSSGPEPPGG---------------------QPDGMK---DLDAIKLFVGQIPRHL 56

  Fly   307 DETRLRQMFEQFGPVHTLNVLRDKVTSISRGCCFVTYYTRKAALRAQDALHNIKTLDGMHHPIQM 371
            ||..|:.:|||||.::.|.||:|..|.:.:||.|:||..|.:|::||.|||..|||.||..|||:
Human    57 DEKDLKPLFEQFGRIYELTVLKDPYTGMHKGCAFLTYCARDSAIKAQTALHEQKTLPGMARPIQV 121

  Fly   372 KPADSENR--NERKLFVGMLNKKYTEADVRQLFTGHGTIEECTVLRDQAGQSKGCAFVTFATKQN 434
            ||||||:|  .:||||||||||:.:|.||.:||...|.|:||||||...|.|||||||.|::...
Human   122 KPADSESRGGRDRKLFVGMLNKQQSEEDVLRLFQPFGVIDECTVLRGPDGSSKGCAFVKFSSHTE 186

  Fly   435 AIGAIKALHQSQTMEGCSAPLVVKFADTQKEKDQKKMQQIHAFCGINTPSGATAGAATPTINAAT 499
            |..||.|||.||||.|.|:.||||||||.||:..::|||:....||.|||
Human   187 AQAAIHALHGSQTMPGASSSLVVKFADTDKERTLRRMQQMVGQLGILTPS--------------- 236

  Fly   500 ALIAAPPSAGRTNPSMAAALAAVPQVQQAGSAATAPTTLVPLNSTTALSASLTPNLLATNAAHQG 564
              :..|.|     |..|.|.|.:.|                  .||.||.|
Human   237 --LTLPFS-----PYSAYAQALMQQ------------------QTTVLSTS-------------- 262

  Fly   565 AAAAAAYLGADPAAAAHLQLYQQLHGYGLSPAHYLPGLNFHHPPENSAHHSQHSPGIGGASAASL 629
                .:||.                          ||:.|      |..|.|.   ||..|
Human   263 ----GSYLS--------------------------PGVAF------SPCHIQQ---IGAVS---- 284

  Fly   630 SAAAATAASNPLGGAPPPTPTPTSSAGHAAGAGLLAAPSMSMQNLVALLATPTAHHQLSLHHSSS 694
                       |.|.|                                 |||.|
Human   285 -----------LNGLP---------------------------------ATPIA----------- 294

  Fly   695 SSGHNNGNSSATSGLHNQRLTYAAAPPPPPISTTYNMPQLI-----GHTATPTQPGG--SSQSLT 752
                      ..||||:           ||:..|..:|.|:     |.......|||  :.:::.
Human   295 ----------PASGLHS-----------PPLLGTTAVPGLVAPITNGFAGVVPFPGGHPALETVY 338

  Fly   753 FNALWP-----PNAADPYSSSLSGLTNGAAY--GAASQPVTTSALQAAAAGVTGKQIEGPDGSNL 810
            .|.|.|     |..|:....:.||:....|.  .||..|:..|..|.... :..:|.|||:|.||
Human   339 ANGLVPYPAQSPTVAETLHPAFSGVQQYTAMYPTAAITPIAHSVPQPPPL-LQQQQREGPEGCNL 402

  Fly   811 FIYHLPQEFIDTDLASTFLPFGNVLSAKVFIDKQTNLSKCFGFVSYDNPHSANAAIQAMHGFQIG 875
            |||||||||.||:|...||||||::|:|||:|:.||.||||||||:|||.||.||||||:|||||
Human   403 FIYHLPQEFGDTELTQMFLPFGNIISSKVFMDRATNQSKCFGFVSFDNPASAQAAIQAMNGFQIG 467

  Fly   876 SKRLKVQLKRSKDAAKPY 893
            .|||||||||.||...||
Human   468 MKRLKVQLKRPKDPGHPY 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bru2	NP_001036356.1	RRM1_CELF1_2_Bruno	294..375	CDD:241075	43/80 (54%)
		RRM2_Bruno_like	381..461	CDD:241080	49/79 (62%)
		RRM_SF	801..892	CDD:302621	67/90 (74%)
CELF5	NP_068757.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..40		9/44 (20%)
		RRM1_CELF3_4_5_6	40..126	CDD:410041	47/88 (53%)
		half-pint	46..>372	CDD:130706	160/498 (32%)
		RRM2_CELF3_4_5_6	133..213	CDD:410043	49/79 (62%)
		RRM3_CELF3_4_5_6	396..474	CDD:241083	58/77 (75%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0144
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1209165at2759
OrthoFinder	1	1.000	-	-		FOG0000286
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100683
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3223
SonicParanoid	1	1.000	-	-		X208
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.750