DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bru2 and celf4

DIOPT Version :9

Sequence 1:	NP_001036356.1	Gene:	bru2 / 250811	FlyBaseID:	FBgn0262475	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	XP_009293466.1	Gene:	celf4 / 436835	ZFINID:	ZDB-GENE-040718-300	Length:	541	Species:	Danio rerio

Alignment Length:	712	Identity:	250/712 - (35%)
Similarity:	327/712 - (45%)	Gaps:	195/712 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 ATATPGTAATAAAAAAAAPSTQLNSSINSRTSLGDQGGAIVVVTPAPPVAAPPTGGPNRNQSPTR 269
            ||.|.|....|....||:.:..:|                               |.:...||..
Zfish     2 ATLTNGQVDAAVHGGAASTNGLVN-------------------------------GISHTHSPAS 35

  Fly   270 DCSVKMELMESTSPDSIKDQPDADNIKMFVGQIPKTWDETRLRQMFEQFGPVHTLNVLRDKVTSI 334
            ..::.|:              |.|.||:|:||||:..||..||.:||:||.::.|.||:|:.|.:
Zfish    36 CATIPMK--------------DHDAIKLFIGQIPRNLDEKDLRPLFEEFGKIYELTVLKDRFTGM 86

  Fly   335 SRGCCFVTYYTRKAALRAQDALHNIKTLDGMHHPIQMKPADSENRNE-RKLFVGMLNKKYTEADV 398
            .:||.|:||..|::||:||.|||..|||.||:.|||:||||||:|.| ||||||||||:..|.||
Zfish    87 HKGCAFLTYCARESALKAQTALHEQKTLPGMNRPIQVKPADSESRGEDRKLFVGMLNKQQCEDDV 151

  Fly   399 RQLFTGHGTIEECTVLRDQAGQSKGCAFVTFATKQNAIGAIKALHQSQTMEGCSAPLVVKFADTQ 463
            |:||...|:|||||:||...|.|||||||.::|...|..||.|||.||||.|.|:.||||||||.
Zfish   152 RRLFESFGSIEECTILRGPDGNSKGCAFVKYSTHAEAQAAISALHGSQTMPGASSSLVVKFADTD 216

  Fly   464 KEKDQKKMQQIHAFCGINTPSGATAGAATPTINAATALIAAPPSAGRTNPSMAAALAAVPQVQQA 528
            ||:..::|||:....||..|.....|                            |..|..||||
Zfish   217 KERTIRRMQQMAGQMGIFNPMALQFG----------------------------AYGAYAQVQQ- 252

  Fly   529 GSAATAPTTLVPLNSTTALSASLTPNLLATNAAHQGAAAAAAYLGADPA-AAAHLQLYQQLHGYG 592
                                          .||...:.....||....| |||.:|....::|
Zfish   253 ------------------------------QAALMASVGQGGYLSPMAAFAAAQMQHMATING-- 285

  Fly   593 LSPAHYLPGLNFHHPPENSAHHSQHSPGIGGASAASLSAAAATAASNPLG-----GAPPPTPTPT 652
                  |||             :..:|..||::...::|...|:..:|:.     |.|||.....
Zfish   286 ------LPG-------------APMTPTSGGSTPPGITAPTVTSIPSPISVNGFTGLPPPQANGQ 331

  Fly   653 SSAGHAAGAGLLAAPSMSMQNLVALLATPTAHHQLSLHHSSSSSGHNNGNSSATSGLHNQRLTYA 717
            :.|......|:...|.:.|                               ||||.  .::||:..
Zfish   332 APAEAMFTNGIHPYPVVFM-------------------------------SSATE--ESKRLSPG 363

  Fly   718 AAPPPPPISTTYNMPQLIGHTATPTQPGGSSQSLTF-----------NALWPPNAADPYSSSLSG 771
            ..|.         :.:::....:.....|.:|...|           :....|.||||...:.:|
Zfish   364 CIPV---------LQEVVFREDSEKGGLGVAQRSCFGVQGSCFLSSLSEAQSPTAADPLQQAYAG 419

  Fly   772 LTN-----GAAYGAASQPVTTSALQAAAAGVTGKQIEGPDGSNLFIYHLPQEFIDTDLASTFLPF 831
            :..     .||||..||     |.......:..:|.|||:|.|||||||||||.|.:|...||||
Zfish   420 VQQYAAAFPAAYGQISQ-----AFPQPPPIIPQQQREGPEGCNLFIYHLPQEFGDGELMQMFLPF 479

  Fly   832 GNVLSAKVFIDKQTNLSKCFGFVSYDNPHSANAAIQAMHGFQIGSKRLKVQLKRSKDAAKPY 893
            |||:|:|||:|:.||.||||||||:|||.||.||||:|:|||||.|||||||||.|||.:||
Zfish   480 GNVISSKVFVDRATNQSKCFGFVSFDNPGSAQAAIQSMNGFQIGMKRLKVQLKRPKDANRPY 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bru2	NP_001036356.1	RRM1_CELF1_2_Bruno	294..375	CDD:241075	43/80 (54%)
		RRM2_Bruno_like	381..461	CDD:241080	51/80 (64%)
		RRM_SF	801..892	CDD:302621	67/90 (74%)
celf4	XP_009293466.1	RRM1_CELF3_4_5_6	42..128	CDD:241076	46/99 (46%)
		ELAV_HUD_SF	49..537	CDD:273741	230/614 (37%)
		RRM2_CELF3_4_5_6	134..214	CDD:241079	50/79 (63%)
		RRM3_CELF3_4_5_6	452..530	CDD:241083	57/77 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579918
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1209165at2759
OrthoFinder	1	1.000	-	-		FOG0000286
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100683
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3223
SonicParanoid	1	1.000	-	-		X208
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.780