DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bru2 and Sxl

DIOPT Version :9

Sequence 1:	NP_001036356.1	Gene:	bru2 / 250811	FlyBaseID:	FBgn0262475	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	NP_001259303.1	Gene:	Sxl / 3772180	FlyBaseID:	FBgn0264270	Length:	722	Species:	Drosophila melanogaster

Alignment Length:	769	Identity:	160/769 - (20%)
Similarity:	246/769 - (31%)	Gaps:	248/769 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   223 PSTQLNSSINSRTSLGDQGGAIVVVTPAPPVAAPPTGGPN--------RNQSPTRDCSVKMELME 279
            ||:......|.....|..||        ...:|...||.|        .|.|....|.:.   :.
  Fly    48 PSSSSRRGYNDFPGCGGSGG--------NGGSANNLGGGNMCHLPPMASNNSLNNLCGLS---LG 101

  Fly   280 STSPDSIKDQPDADNIKMFVGQIPKTWDETRLRQMFEQFGPVHTLNVLRDKVTSISRGCCFVTYY 344
            |...|.:.:.|.|.|..:.|..:|:...:..|..:|...||::|..::||..|..|.|..||.:.
  Fly   102 SGGSDDLMNDPRASNTNLIVNYLPQDMTDRELYALFRAIGPINTCRIMRDYKTGYSFGYAFVDFT 166

  Fly   345 TRKAALRAQDALHNIKTLDGMHHPIQMKPADSENRNERKLFVGMLNKKYTEADVRQLFTGHGTIE 409
            :...:.||...|:.| |:......:.......|:..:..|:|..|.:..|:..:..:|..:|:|.
  Fly   167 SEMDSQRAIKVLNGI-TVRNKRLKVSYARPGGESIKDTNLYVTNLPRTITDDQLDTIFGKYGSIV 230

  Fly   410 ECTVLRDQ-AGQSKGCAFVTFATKQNAIGAIKALHQSQTMEGCSAPLVVKFADTQ-KEKDQKKMQ 472
            :..:|||: .|:.:|.|||.:..::.|..||.||: :...||.|.||.|:.|:.. |.|....|.
  Fly   231 QKNILRDKLTGRPRGVAFVRYNKREEAQEAISALN-NVIPEGGSQPLSVRLAEEHGKAKAAHFMS 294

  Fly   473 QIHAFCGINTPSGATAGAATPTINAATALIAAPPSAGRTNPSMAAALAAVPQVQQAGSAATAPTT 537
            |                     :....|.:..||      |...|.:||
  Fly   295 Q---------------------MGVVPANVPPPP------PQPPAHMAA---------------- 316

  Fly   538 LVPLNSTTALSASLTPNLLATNAAHQ-GA---------AAAAAYLGADPAAAAHLQLYQQLHGYG 592
                               |.|..|: ||         |...|..|.|....|.|
  Fly   317 -------------------AFNMMHRDGAMEKLRSLFDAICDAIFGLDSENFADL---------- 352

  Fly   593 LSPAHYLPGL---NFHHP-----PENSAHHSQHSPGIGGASAASLSAAAATAASNPLGGAPPPTP 649
                  |.||   .:|:|     |:......||..          .|...|::||
  Fly   353 ------LDGLYRRKYHYPYLXLTPQQQQQLLQHQQ----------QALGFTSSSN---------- 391

  Fly   650 TPTSSAGHAAGAGLLAAPSMSMQNLVALLATPTAHHQ----------LSLHHSSSSSGHNNGNSS 704
               :|.|:..|            |...:|.....:||          ::.|:.|.:..:||.|:|
  Fly   392 ---NSIGNGNG------------NDNNMLLYHQQYHQQQTQQQRLGNVAAHNISPNGSNNNINTS 441

  Fly   705 ATSGLH-------------------------------NQRLTYAAAPP----------PPPISTT 728
            .|:.::                               .|.||..::||          ....||.
  Fly   442 NTNNINFNTIRQNGVAALHYLQEQLQLQQPQDQQSQQQQPLTMPSSPPFQQQSRQSHHNGSSSTL 506

  Fly   729 YNMPQLIGHTATPTQPGGSSQSLTFNALWPPNAADPYSSSLSGLTNGAAYGA-------ASQPVT 786
            .|....|.:..:.......|.|.|.|          ||:..:..:|||..|:       :|...|
  Fly   507 GNQLLAISNNNSFNNNSNQSNSFTGN----------YSNGSAFTSNGAISGSNFPNNPTSSGNFT 561

  Fly   787 TSALQAAAAGVTGKQIEGPDGSNLFIYHLPQEFIDTDLASTFLPFGNVLSAKVFID---KQTNLS 848
            .::..:.... :|.......||:.|..||......|:....|.  .|..|:..|.:   ..||.|
  Fly   562 NNSTNSNPTN-SGHFASNLAGSSNFTNHLSGSNNYTNSNGNFT--SNAASSSNFSNNAASSTNYS 623

  Fly   849 K-C-FGFVSYDNPHSA---------NAAIQAMHGF---------QIGSKRLKVQ 882
            | | .|.|...:|.|.         |......|.|         ::..:.||:|
  Fly   624 KNCSSGVVGNSDPDSCSRKHTTNTNNHHTSPQHDFSFNMSTTEQELHQQTLKLQ 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bru2	NP_001036356.1	RRM1_CELF1_2_Bruno	294..375	CDD:241075	20/80 (25%)
		RRM2_Bruno_like	381..461	CDD:241080	26/80 (33%)
		RRM_SF	801..892	CDD:302621	25/105 (24%)
Sxl	NP_001259303.1	RRM1_SXL	117..197	CDD:241093	19/80 (24%)
Sxl	NP_001259303.1	RRM2_Hu_like	203..281	CDD:240822	26/78 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	76	1.000	Inparanoid score	I1646
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24012
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.060