DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bru2 and bru1

DIOPT Version :9

Sequence 1:	NP_001036356.1	Gene:	bru2 / 250811	FlyBaseID:	FBgn0262475	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	NP_001260403.1	Gene:	bru1 / 34648	FlyBaseID:	FBgn0000114	Length:	810	Species:	Drosophila melanogaster

Alignment Length:	1007	Identity:	364/1007 - (36%)
Similarity:	459/1007 - (45%)	Gaps:	312/1007 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 MLQSLSLHADKLSGNSPAAAAATGAAAATSEAT-------------AVASAAAATTMLATAP--- 50
            ||.||    |.|:|....|...|||..|.|:.|             :..........||.:|
  Fly     1 MLSSL----DALAGKIATATPGTGAVTADSKNTQSLHHHHRLDYDYSAVEIEPPAEQLANSPRSE 61

  Fly    51 ---VAHVANGNNSNSSA-----------------GSSSNSNSSSNNHSLYSNNNLNTGNNSQQQQ 95
               :..........:.|                 .|.|..:..|::|.|..:..||       ||
  Fly    62 RERLQQAQQAYEQQAQAELEFGLAEVDAKLTQLKSSHSLQHHHSHHHQLQRHTALN-------QQ 119

  Fly    96 QQQQQHPQILPVKYEYLENLTSSGATSGAIAATTTFTGAAKSFHPYLRP---------TGSGSNS 151
            |||..|.|.....:.:                           |||.||         |.|....
  Fly   120 QQQLHHHQPHHNHHHH---------------------------HPYQRPRPTSPPQQQTSSYQQQ 157

  Fly   152 NNSIAALS------TTTAATAAKMSTTLFE--------------------------TLLHNQINS 184
            .:.:|||.      .|......|...|:.|                          :.:.|....
  Fly   158 LSQLAALQDHHDLLQTQQELFHKQLATMQEYQRERERERERERERERERERERDRSSFIDNSDYD 222

  Fly   185 SPIALPAATAIAAISAAATAATATPGTAATAAAAAAAAPS-----------TQLNSSI-----NS 233
            |..........:|...:..:::||.....:...:....||           |..|:|:     ||
  Fly   223 SQTEFKICLRDSAFGMSDKSSSATNSLPNSPIHSNNNNPSLLNNNNNNSNGTSSNNSLNVGNNNS 287

  Fly   234 RTSL-GDQGGAIVVVTPAPPVAAPPTGGPNRNQSPTRDCSVKMELMESTSPDSI----------- 286
            ..|| |....|:|.|.....::|  .|..|.|.:|   ||....::.....|:.
  Fly   288 NPSLGGSNSNALVSVGSNGIMSA--AGLVNNNNNP---CSANRNVVAMVDDDACFRLDTDATVTY 347

  Fly   287 -KDQPDADNIKMFVGQIPKTWDETRLRQMFEQFGPVHTLNVLRDKVTSISRGCCFVTYYTRKAAL 350
             :.:||.|||||||||:||:.||::||:|||::|.||::||||||.|.||:||||||:|||.|||
  Fly   348 GEKEPDPDNIKMFVGQVPKSMDESQLREMFEEYGAVHSINVLRDKATGISKGCCFVTFYTRHAAL 412

  Fly   351 RAQDALHNIKTLDGMHHPIQMKPADSENRNERKLFVGMLNKKYTEADVRQLFTGHGTIEECTVLR 415
            :|||||||:|||:||:||||||||||||||||||||||||||..|.|||:||..||.||||||||
  Fly   413 KAQDALHNVKTLNGMYHPIQMKPADSENRNERKLFVGMLNKKLNENDVRKLFEVHGAIEECTVLR 477

  Fly   416 DQAGQSKGCAFVTFATKQNAIGAIK-ALHQSQTMEGCSAPLVVKFADTQKEKDQKKMQQIHA--- 476
            ||.||||||||||||||..||.||| .|.|::.||||::|||||||||||||:|||:|||.|
  Fly   478 DQNGQSKGCAFVTFATKHAAISAIKVTLSQNKIMEGCTSPLVVKFADTQKEKEQKKIQQIQANLW 542

  Fly   477 --FCGINTPSGATAGAATPTINAATALIAAPPSAGRTNPSMAAALAAVPQVQQAGSAATAPTTLV 539
              ...||.|.|.||.:.|      |.::..||.    .||
  Fly   543 NLASNINIPLGQTATSVT------TPILPNPPQ----QPS------------------------- 572

  Fly   540 PLNSTTALSASLTPNLLATNAAHQGAAAAAAYLGADPAAAAHLQLYQQLHGYGLSPAHYLPGLNF 604
            |:                              ||||....|.:||.|||...||.  |.|
  Fly   573 PV------------------------------LGADAITPASIQLLQQLQAVGLQ--HQL----- 600

  Fly   605 HHPPENSAHHSQHSPGIGGASAASLSAAAATAASNPLGGAPPPTPTPTSSAGHAAGAGLLAAPSM 669
                      .|...|:|...::|.:..:|.||                       ||||.  .|
  Fly   601 ----------LQALTGLGAQQSSSATDTSAVAA-----------------------AGLLT--PM 630

  Fly   670 SMQNLVALLATPTAHHQLSLHHSSSSSGHNNGNSSATSGLHNQRLTYAAAPPPPPISTTYNMPQL 734
            ::|||.|:.|..    |.||.::::::
  Fly   631 TVQNLAAIAAMT----QPSLSNAAAAA-------------------------------------- 653

  Fly   735 IGHTATPTQPGGSSQSLTFNALW--PPNAADPYSSSLSGLTN-GAAYGAASQPVTTSALQAAAAG 796
                |..|.||.:..:.|...||  |...|..|.|:.:||.. |:|...::.|:.:.||.||||.
  Fly   654 ----AAATSPGSAQLTNTAALLWSDPNPMASAYMSTAAGLPQFGSASALSTSPLASVALSAAAAA 714

  Fly   797 VTGKQIEGPDGSNLFIYHLPQEFIDTDLASTFLPFGNVLSAKVFIDKQTNLSKCFGFVSYDNPHS 861
            ..|||||||:|.|||||||||||.||||||||||||||:||||||||||:|||||||||:|||.|
  Fly   715 AAGKQIEGPEGCNLFIYHLPQEFTDTDLASTFLPFGNVISAKVFIDKQTSLSKCFGFVSFDNPDS 779

  Fly   862 ANAAIQAMHGFQIGSKRLKVQLKRSKDAAKPY 893
            |..||:||:|||:|:||||||||:.|| :|||
  Fly   780 AQVAIKAMNGFQVGTKRLKVQLKKPKD-SKPY 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bru2	NP_001036356.1	RRM1_CELF1_2_Bruno	294..375	CDD:241075	60/80 (75%)
		RRM2_Bruno_like	381..461	CDD:241080	61/80 (76%)
		RRM_SF	801..892	CDD:302621	73/90 (81%)
bru1	NP_001260403.1	RRM1_CELF1_2_Bruno	356..437	CDD:241075	60/80 (75%)
		ELAV_HUD_SF	359..808	CDD:273741	283/602 (47%)
		RRM2_Bruno_like	443..524	CDD:241080	61/80 (76%)
		RRM3_Bruno_like	722..800	CDD:241084	64/77 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45448472
Domainoid	1	1.000	95	1.000	Domainoid score	I2491
eggNOG	1	0.900	-	-		E1_KOG0144
Homologene	1	1.000	-	-		H4783
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2786
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110700at50557
OrthoFinder	1	1.000	-	-		FOG0000286
OrthoInspector	1	1.000	-	-		mtm1163
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24012
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2990
SonicParanoid	1	1.000	-	-		X208
	12	11.830