Protein Alignment bru2 and Celf2

DIOPT Version :10

• Sequence 1: NP_001036356.1
• Gene: bru2 / 250811
• FlyBaseID: FBgn0262475
• Length: 893
• Species: Drosophila melanogaster
• Sequence 2: NP_001393872.1
• Gene: Celf2 / 14007
• MGIID: 1338822
• Length: 546
• Species: Mus musculus
• Alignment Length: 625
• Identity: 265/625 - (42%)
• Similarity: 335/625 - (53%)
• Gaps: 164/625 - (26%)

  Fly   288 DQPDADNIKMFVGQIPKTWDETRLRQMFEQFGPVHTLNVLRDKVTS--ISRGCCFVTYYTRKAAL 350
            ||||.|.|||||||||::|.|..|:::||.:|.|:.:|||||:..:  .|:||||||:|||||||
Mouse    67 DQPDPDAIKMFVGQIPRSWSEKELKELFEPYGAVYQINVLRDRSQNPPQSKGCCFVTFYTRKAAL 131

  Fly   351 RAQDALHNIKTLDGMHHPIQMKPADSENRN---ERKLFVGMLNKKYTEADVRQLFTGHGTIEECT 412
            .||:||||||||.||||||||||||||..|   :||||:||::||..|.|:|.:|:..|.||||.
Mouse   132 EAQNALHNIKTLPGMHHPIQMKPADSEKSNAVEDRKLFIGMVSKKCNENDIRVMFSPFGQIEECR 196

  Fly   413 VLRDQAGQSKGCAFVTFATKQNAIGAIKALHQSQTMEGCSAPLVVKFADTQKEKDQKKMQQIHAF 477
            :||...|.|:|||||||:|:..|..||||:||||||||||:|:|||||||||:|:|:::||
Mouse   197 ILRGPDGLSRGCAFVTFSTRAMAQNAIKAMHQSQTMEGCSSPIVVKFADTQKDKEQRRLQQ---- 257

  Fly   478 CGINTPSGATAGAATPTINAATALIAAPPSAGRTNPSMAAALAAVPQVQQAGSAATAPTTLVPLN 542
                                                      ....|:||..:|.        ..
Mouse   258 ------------------------------------------QLAQQMQQLNTAT--------WG 272

  Fly   543 STTALSASLTPNLLATNAAHQGAAAAAAYLGADPAAAAHLQLYQQLHGYGLSPAHYLPGLNFHHP 607
            :.|.| ..|||..||.    ...|.:::.|||                  .|....:.|:|
Mouse   273 NLTGL-GGLTPQYLAL----LQQATSSSNLGA------------------FSGIQQMAGMN---- 310

  Fly   608 PENSAHHSQHSPGIGGASAASLSAAAATAASNPLGG---------APPPTPTPTSSAGHAAGAGL 663
                |...|:...:..|:||:.::|.:|.| |||..         :|....||.|:||.|
Mouse   311 ----ALQLQNLATLAAAAAAAQTSATSTNA-NPLSSTSSALGALTSPVAASTPNSTAGAA----- 365

  Fly   664 LAAPSMSMQNLVALLATPTAHHQLSLHHSSSSSGHNNGNSSATSGLHNQRLTYAAAPPPPPISTT 728
                   |.:|.:|                   |...|.:.||.||:|   ..|.|      .|.
Mouse   366 -------MNSLTSL-------------------GTLQGLAGATVGLNN---INALA------GTI 395

  Fly   729 YNMPQL---IGHTATPTQPGGSSQSLTFNALWPPNAADPYSSSLSGLTNGAAYGAASQPV--TTS 788
            .:|..|   :|.|.......|:..:||              .:.||:..   |.||:.|.  :.|
Mouse   396 NSMAALNGGLGATGLTNGTAGTMDALT--------------QAYSGIQQ---YAAAALPTLYSQS 443

  Fly   789 ALQAAAAGVTGKQIEGPDGSNLFIYHLPQEFIDTDLASTFLPFGNVLSAKVFIDKQTNLSKCFGF 853
            .||..:|  .|.|.|||:|:|||||||||||.|.|:...|:|||||:||||||||||||||||||
Mouse   444 LLQQQSA--AGSQKEGPEGANLFIYHLPQEFGDQDILQMFMPFGNVISAKVFIDKQTNLSKCFGF 506

  Fly   854 VSYDNPHSANAAIQAMHGFQIGSKRLKVQLKRSKDAAKPY 893
            ||||||.||.||||||:|||||.|||||||||||:.:|||
Mouse   507 VSYDNPVSAQAAIQAMNGFQIGMKRLKVQLKRSKNDSKPY 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bru2	NP_001036356.1	RRM_SF	294..375	CDD:473069	55/82 (67%)
		RRM_SF	381..461	CDD:473069	49/79 (62%)
		RRM_SF	801..892	CDD:473069	72/90 (80%)
Celf2	NP_001393872.1	RRM1_CELF1_2_Bruno	73..156	CDD:410040	55/82 (67%)
		RRM2_CELF1_2	165..245	CDD:410042	49/79 (62%)
		RRM3_CELF1_2	454..545	CDD:241082	72/90 (80%)