DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bru2 and Celf4

DIOPT Version :9

Sequence 1:	NP_001036356.1	Gene:	bru2 / 250811	FlyBaseID:	FBgn0262475	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	NP_001349204.1	Gene:	Celf4 / 108013	MGIID:	1932407	Length:	554	Species:	Mus musculus

Alignment Length:	707	Identity:	217/707 - (30%)
Similarity:	287/707 - (40%)	Gaps:	243/707 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 ATAAAAAAAAPSTQLNSSINSRTSLGDQGGAIVVVTPAPPVAAPPTGGPNRNQSPTRDCSVKMEL 277
            ||.|...|...|...|...:|..|.|...|.                    :.||....::.|:
Mouse     6 ATLANGQADNASLSTNGLGSSPGSAGHMNGL--------------------SHSPGNPSTIPMK- 49

  Fly   278 MESTSPDSIKDQPDADNIKMFVGQIPKTWDETRLRQMFEQFGPVHTLNVLRDKVTSISRGCCFVT 342
                         |.|.||:|:||||:..||..|:.:||:||.::.|.||:|:.|.:.:||.|:|
Mouse    50 -------------DHDAIKLFIGQIPRNLDEKDLKPLFEEFGKIYELTVLKDRFTGMHKGCAFLT 101

  Fly   343 YYTRKAALRAQDALHNIKTLDGMHHPIQMKPADSENR----------NERKLFVGMLNKKYTEAD 397
            |..|::||:||.|||..|||.||:.|||:||||||:|          :.||||||||||:.:|.|
Mouse   102 YCERESALKAQSALHEQKTLPGMNRPIQVKPADSESRGGSSCLRQPPSHRKLFVGMLNKQQSEDD 166

  Fly   398 VRQLFTGHGTIEECTVLRDQAGQSKGCAFVTFATKQNAIGAIKALHQSQTMEGCSAPLVVKFADT 462
            ||:||...|.|||||:||...|.|||||||.:::...|..||.|||.||||.|.|:.||||||||
Mouse   167 VRRLFEAFGNIEECTILRGPDGNSKGCAFVKYSSHAEAQAAINALHGSQTMPGASSSLVVKFADT 231

  Fly   463 QKEKDQKKMQQIHAFCGINTPS----GATAGAATPTINAATALIAAPPSAGRTNPSMAAALAAVP 523
            .||:..::|||:....|:..|.    ||....|...:....||:|:....|..|| |||..||
Mouse   232 DKERTMRRMQQMAGQMGMFNPMAIPFGAYGAYAQALMQQQAALMASVAQGGYLNP-MAAFAAA-- 293

  Fly   524 QVQQAGSAATAPTTLVPLNSTTALSASLTPNLLATNAAHQGAAAAAAYLGADPAAAAHLQLYQQL 588
            |:||          :..||.....:|.:||.
Mouse   294 QMQQ----------MAALNMNGLAAAPMTPT---------------------------------- 314

  Fly   589 HGYGLSPAHYLPGLNFHHPPENSAHHSQHSPGIGGASAASLSAAAATAASNPLGGAPPPTPTPTS 653
                                                                .||:.||
Mouse   315 ----------------------------------------------------SGGSTPP------ 321

  Fly   654 SAGHAAGAGLLAAPSMSMQNLVALLATPTAHHQLSLHHSSSSSGHNNGNSSATSGLHNQRLTYAA 718
                  |....|.||:
Mouse   322 ------GITAPAVPSI------------------------------------------------- 331

  Fly   719 APPPPPISTTYNMPQLIGHTATPTQPGG--SSQSLTFNALWP-----PNAADPYSSSLSGLTN-- 774
               |.||...       |.|..|.|..|  :::::..|.:.|     |.||||...:.:|:..
Mouse   332 ---PSPIGVN-------GFTGLPPQANGQPAAEAVFANGIHPYPAQSPTAADPLQQAYAGVQQYA 386

  Fly   775 ----GAAYGAASQPVTTSALQAAAAGVTGKQIEGPDGSNLFIYHLPQEFIDTDLASTFLPFGNVL 835
                .||||..||     |.......:..:|.|||:|.||.||||||||.|.:|...|||||||:
Mouse   387 GPAYPAAYGQISQ-----AFPQPPPMIPQQQREGPEGCNLLIYHLPQEFGDAELMQMFLPFGNVI 446

  Fly   836 SAKVFIDKQTNLSKCFGFVSYDNPHSANAAIQAMHGFQIGSKRLKVQLKRSKDAAKP 892
            |:|||:|:.||.|||||      .|...:..|| ...|.|...:....:|.::..:|
Mouse   447 SSKVFVDRATNQSKCFG------RHPVPSRCQA-PSCQGGQCAISSSARRLRELRQP 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bru2	NP_001036356.1	RRM1_CELF1_2_Bruno	294..375	CDD:241075	42/80 (53%)
		RRM2_Bruno_like	381..461	CDD:241080	49/79 (62%)
		RRM_SF	801..892	CDD:302621	42/90 (47%)
Celf4	NP_001349204.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..39		5/40 (13%)
		RRM1_CELF3_4_5_6	49..135	CDD:241076	45/99 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..149		13/27 (48%)
		RRM2_CELF3_4_5_6	150..230	CDD:241079	49/79 (62%)
		Necessary for TNNT2 exon 5 inclusion. /evidence=ECO:0000250	238..257		5/18 (28%)
		RRM_SF	415..>463	CDD:388407	32/47 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836404
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0144
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1209165at2759
OrthoFinder	1	1.000	-	-		FOG0000286
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100683
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3223
SonicParanoid	1	1.000	-	-		X208
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.680