Protein Alignment bru2 and CELF1

DIOPT Version :9

• Sequence 1: NP_001036356.1
• Gene: bru2 / 250811
• FlyBaseID: FBgn0262475
• Length: 893
• Species: Drosophila melanogaster
• Sequence 2: NP_001317201.1
• Gene: CELF1 / 10658
• HGNCID: 2549
• Length: 514
• Species: Homo sapiens
• Alignment Length: 647
• Identity: 270/647 - (41%)
• Similarity: 344/647 - (53%)
• Gaps: 173/647 - (26%)

  Fly   271 CSVKMELMESTSPDSIK--------DQPDADNIKMFVGQIPKTWDETRLRQMFEQFGPVHTLNVL 327
            ||:      ::||.|.|        ||||.|.|||||||:|:||.|..||::|||:|.|:.:|||
Human    17 CSL------NSSPVSKKMNGTLDHPDQPDLDAIKMFVGQVPRTWSEKDLRELFEQYGAVYEINVL 75

  Fly   328 RDKVTS--ISRGCCFVTYYTRKAALRAQDALHNIKTLDGMHHPIQMKPADSENRN---ERKLFVG 387
            ||:..:  .|:||||||:|||||||.||:||||:|.|.||||||||||||||..|   :||||:|
Human    76 RDRSQNPPQSKGCCFVTFYTRKAALEAQNALHNMKVLPGMHHPIQMKPADSEKNNAVEDRKLFIG 140

  Fly   388 MLNKKYTEADVRQLFTGHGTIEECTVLRDQAGQSKGCAFVTFATKQNAIGAIKALHQSQTMEGCS 452
            |::||.||.|:|.:|:..|.||||.:||...|.|:|||||||.|:..|..||||:||:|||||||
Human   141 MISKKCTENDIRVMFSSFGQIEECRILRGPDGLSRGCAFVTFTTRAMAQTAIKAMHQAQTMEGCS 205

  Fly   453 APLVVKFADTQKEKDQKKMQQIHAFCGINTPSGATAGAATPTINAATALIAAPPSAGRTNPSMAA 517
            :|:|||||||||:|:||:|.|
Human   206 SPMVVKFADTQKDKEQKRMAQ-------------------------------------------- 226

  Fly   518 ALAAVPQVQQAGSAATAPTTLVPLNSTTALSASLTPNLLATNAAHQGAAAAAAYLGADPAAAAHL 582
               .:.|..|..|||:....|..||       :|.|..|                      |.:|
Human   227 ---QLQQQMQQISAASVWGNLAGLN-------TLGPQYL----------------------ALYL 259

  Fly   583 QLYQQLHGYG----LSPAHYLPGLNFHHPPENSAHHSQHSPGIGGASAASLSAAAATAASNPLG- 642
            ||.||....|    ||..|.:.|||        |...|        :.|:|:|||:.|.:.|.|
Human   260 QLLQQTASSGNLNTLSSLHPMGGLN--------AMQLQ--------NLAALAAAASAAQNTPSGT 308

  Fly   643 ----GAPPPTPTPTSSAGHAAGAGLLAAPSMSMQNLVALLATPTAHHQLSLHHSSSSSGHNNGNS 703
                .:..|....|||||        ::||.|..|.|..:|:..|...|    :.:::|.|.|:.
Human   309 NALTTSSSPLSVLTSSAG--------SSPSSSSSNSVNPIASLGALQTL----AGATAGLNVGSL 361

  Fly   704 SATSGLHNQRLTYAAAPPPPPISTTYNMPQLIGHTATPTQPGGSSQSLTFNALWPPNAADPYSSS 768
            :..:.|:..                      :|.:......|.:.::||              .:
Human   362 AGMAALNGG----------------------LGSSGLSNGTGSTMEALT--------------QA 390

  Fly   769 LSGLTNGAAYGAASQPV--TTSALQAAAAGVTGKQIEGPDGSNLFIYHLPQEFIDTDLASTFLPF 831
            .||:..   |.||:.|.  ..:.|...:.|..|.|.|||:|:|||||||||||.|.||...|:||
Human   391 YSGIQQ---YAAAALPTLYNQNLLTQQSIGAAGSQKEGPEGANLFIYHLPQEFGDQDLLQMFMPF 452

  Fly   832 GNVLSAKVFIDKQTNLSKCFGFVSYDNPHSANAAIQAMHGFQIGSKRLKVQLKRSKDAAKPY 893
            |||:||||||||||||||||||||||||.||.||||:|:|||||.|||||||||||:.:|||
Human   453 GNVVSAKVFIDKQTNLSKCFGFVSYDNPVSAQAAIQSMNGFQIGMKRLKVQLKRSKNDSKPY 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bru2	NP_001036356.1	RRM1_CELF1_2_Bruno	294..375	CDD:241075	55/82 (67%)
		RRM2_Bruno_like	381..461	CDD:241080	49/79 (62%)
		RRM_SF	801..892	CDD:302621	72/90 (80%)
CELF1	NP_001317201.1	RRM1_CELF1_2_Bruno	42..125	CDD:410040	55/82 (67%)
		RRM2_CELF1_2	134..214	CDD:410042	49/79 (62%)
		RRM3_CELF1_2	422..513	CDD:241082	72/90 (80%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146317
Domainoid	1	1.000	97	1.000	Domainoid score	I7253
eggNOG	1	0.900	-	-		E1_KOG0144
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2786
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1209165at2759
OrthoFinder	1	1.000	-	-		FOG0000286
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24012
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2990
SonicParanoid	1	1.000	-	-		X208
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.790