Protein Alignment bwa and ACER2

DIOPT Version :9

• Sequence 1: NP_001260616.1
• Gene: bwa / 250736
• FlyBaseID: FBgn0045064
• Length: 300
• Species: Drosophila melanogaster
• Sequence 2: NP_001010887.2
• Gene: ACER2 / 340485
• HGNCID: 23675
• Length: 275
• Species: Homo sapiens
• Alignment Length: 257
• Identity: 127/257 - (49%)
• Similarity: 178/257 - (69%)
• Gaps: 1/257 - (0%)

  Fly    17 WEHLRPGSSPVDWCEGNYLISSNIAEFVNTFSNFLFILLPPVLIMLFKEYGRFVTPGIHVIWVLL 81
            |:.|:.|||.|||||.||.|...||||.||.||.||.:|||:.:.||::|......||::||.||
Human     7 WDQLQAGSSEVDWCEDNYTIVPAIAEFYNTISNVLFFILPPICMCLFRQYATCFNSGIYLIWTLL 71

  Fly    82 IVVGLSSMYFHATLSLIGQLLDELAILWVFMAAFSLFYPKRYYPKFVKNDRKTFSWLMLLSAIAA 146
            :|||:.|:|||||||.:||:|||||:|||.|.|.::::|:||.||..:|||..|..::.:.:...
Human    72 VVVGIGSVYFHATLSFLGQMLDELAVLWVLMCALAMWFPRRYLPKIFRNDRGRFKVVVSVLSAVT 136

  Fly   147 TGLSWWKPIVNAFVLMFMSVPTMVMLYTELQRVSDQRVYRLGIRSTTVWAVAVFCWINDRIFCEA 211
            |.|::.||.:|...||.:.||...:|..||:|..:.||::||:.|...|.:|:||||:||.|||.
Human   137 TCLAFVKPAINNISLMTLGVPCTALLIAELKRCDNMRVFKLGLFSGLWWTLALFCWISDRAFCEL 201

  Fly   212 WSSINFPYLHGFWHIFIFIAAYTVLVLFAYFYVESELPQRQPLLKYWPKNEFEF-GIPFISI 272
            .||.||||||..|||.|.:|||...|.||||...||:|::.|::|:||..::.| |:|::|:
Human   202 LSSFNFPYLHCMWHILICLAAYLGCVCFAYFDAASEIPEQGPVIKFWPNEKWAFIGVPYVSL 263

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bwa	NP_001260616.1	Ceramidase	22..270	CDD:283521	124/248 (50%)
ACER2	NP_001010887.2	Required for proper localization to the Golgi apparatus. /evidence=ECO:0000269|PubMed:20089856	1..13		2/5 (40%)
		Ceramidase	13..261	CDD:368648	124/247 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156579
Domainoid	1	1.000	266	1.000	Domainoid score	I1896
eggNOG	1	0.900	-	-		E1_KOG2329
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14986
Inparanoid	1	1.050	282	1.000	Inparanoid score	I2890
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49319
OrthoDB	1	1.010	-	-		D467572at33208
OrthoFinder	1	1.000	-	-		FOG0003532
OrthoInspector	1	1.000	-	-		oto89713
orthoMCL	1	0.900	-	-		OOG6_108491
Panther	1	1.100	-	-	LDO	PTHR46139
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2379
SonicParanoid	1	1.000	-	-		X4505
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800