DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bwa and acer2

DIOPT Version :9

Sequence 1:	NP_001260616.1	Gene:	bwa / 250736	FlyBaseID:	FBgn0045064	Length:	300	Species:	Drosophila melanogaster
Sequence 2:	XP_002663077.2	Gene:	acer2 / 100331179	ZFINID:	ZDB-GENE-121026-1	Length:	277	Species:	Danio rerio

Alignment Length:	271	Identity:	138/271 - (50%)
Similarity:	188/271 - (69%)	Gaps:	7/271 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 AMAWEHLRPGSSPVDWCEGNYLISSNIAEFVNTFSNFLFILLPPVLIMLFKEYGRFVTPGIHVIW 78
            |..|:||:.|||.||||||||||...||||.||.||.||.:|||:|:.||::|......||::||
Zfish     6 AHLWDHLQAGSSEVDWCEGNYLIYPGIAEFYNTISNVLFFVLPPILMCLFRQYATHFNSGIYLIW 70

  Fly    79 VLLIVVGLSSMYFHATLSLIGQLLDELAILWVFMAAFSLFYPKRYYPKFVKNDRKTFSWLM-LLS 142
            .||:|||:.|.|||||||.:||:|||||||||.|.|..:::||||.||..:.||..|..:: :||
Zfish    71 TLLVVVGIGSTYFHATLSFLGQMLDELAILWVLMCAIGMWFPKRYLPKIFRRDRSRFKMVIGVLS 135

  Fly   143 AIAATGLSWWKPIVNAFVLMFMSVPTMVMLYTELQRVSDQRVYRLGIRSTTVWAVAVFCWINDRI 207
            .| .|.|::.||.:|:..||.:.:|...:|.|||:|..:.||::||:.|...|.:|:.|||:|||
Zfish   136 GI-TTCLAFIKPAINSITLMTLGIPCTALLITELKRCDNLRVFKLGLLSGLWWTLALMCWISDRI 199

  Fly   208 FCEAWSSINFPYLHGFWHIFIFIAAYTVLVLFAYFYVESELPQRQPLLKYWPKNEFEF-GIPFIS 271
            |||.|||:||||||..|||.|.:|:|...|.||||...||.|::.|::|:||..::.| |:|:::
Zfish   200 FCEMWSSVNFPYLHCAWHILICLASYLGCVCFAYFDAASEAPEQGPVVKFWPSEKWAFIGVPYVT 264

  Fly   272 I----RNPDSK 278
            :    |.|..|
Zfish   265 LLCVHRKPSIK 275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bwa	NP_001260616.1	Ceramidase	22..270	CDD:283521	131/249 (53%)
acer2	XP_002663077.2	Ceramidase	15..263	CDD:283521	131/248 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592202
Domainoid	1	1.000	276	1.000	Domainoid score	I1709
eggNOG	1	0.900	-	-		E1_KOG2329
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14986
Inparanoid	1	1.050	294	1.000	Inparanoid score	I2753
OMA	1	1.010	-	-		QHG49319
OrthoDB	1	1.010	-	-		D467572at33208
OrthoFinder	1	1.000	-	-		FOG0003532
OrthoInspector	1	1.000	-	-		oto40675
orthoMCL	1	0.900	-	-		OOG6_108491
Panther	1	1.100	-	-	LDO	PTHR46139
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2379
SonicParanoid	1	1.000	-	-		X4505
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800