Protein Alignment fdl and HEXB

DIOPT Version :9

• Sequence 1: NP_725178.2
• Gene: fdl / 250735
• FlyBaseID: FBgn0045063
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_000512.2
• Gene: HEXB / 3074
• HGNCID: 4879
• Length: 556
• Species: Homo sapiens
• Alignment Length: 593
• Identity: 185/593 - (31%)
• Similarity: 265/593 - (44%)
• Gaps: 134/593 - (22%)

  Fly   110 IWPHPTQKFLLSSQTHSFSVEDVQLHVDTAHREVRKQLQLAFDWFLKDLRLIQRLDYVGSSSEPT 174
            :||.|    ||...|.:.                   |.||.:.|           |:..|...|
Human    56 LWPLP----LLVKMTPNL-------------------LHLAPENF-----------YISHSPNST 86

  Fly   175 VSES-----SSKSRHHADLEPAATLFG--------ATFGVKKAGDLTSVQ---VKISVLKSGDLN 223
            ...|     .:..|:|      ..:||        |.|..|     |.||   |.|::....|..
Human    87 AGPSCTLLEEAFRRYH------GYIFGFYKWHHEPAEFQAK-----TQVQQLLVSITLQSECDAF 140

  Fly   224 FSLDNDETYQLSTQTEGHRLQVEII-ANSYFGARHGLSTLQQLIWFDDEDHLLHTYANSKVKDAP 287
            .::.:||:|.|..:.     .|.:: ||..:||..||.|..||::.|  .:...|...|.:.|:|
Human   141 PNISSDESYTLLVKE-----PVAVLKANRVWGALRGLETFSQLVYQD--SYGTFTINESTIIDSP 198

  Fly   288 KFRYRGLMLDTSRHFFSVESIKRTIVGMGLAKMNRFHWHLTDAQSFPYISRYYPELAVHGAYSES 352
            :|.:||:::|||||:..|:.|.:|:..|...|.|..|||:.|.|||||.|..:|||:..|:||.|
Human   199 RFSHRGILIDTSRHYLPVKIILKTLDAMAFNKFNVLHWHIVDDQSFPYQSITFPELSNKGSYSLS 263

  Fly   353 ETYSEQDVREVAEFAKIYGVQVIPEIDAPAHAGNGWDWGPKRGMGE-LAMCINQQPW--SFYCGE 414
            ..|:..|||.|.|:|::.|::|:||.|.|.|.   ..||  :|..: |..|.::|..  ||
Human   264 HVYTPNDVRMVIEYARLRGIRVLPEFDTPGHT---LSWG--KGQKDLLTPCYSRQNKLDSF---- 319

  Fly   415 PPCGQLNPKNNYTYLILQRIYEELLQHTGPTDFFHLGGDEVNLDCW----------AQYFNDTDL 469
               |.:||..|.||..|...::| :....|..|.|||||||...||          .|....||.
Human   320 ---GPINPTLNTTYSFLTTFFKE-ISEVFPDQFIHLGGDEVEFKCWESNPKIQDFMRQKGFGTDF 380

  Fly   470 RGLWCDFMLQAMARLKLANNGVAPKHVAVWSSALTN-TKCLPNSQFTVQVWGGSTWQENYD-LLD 532
            :.|...::.:.:..:...|.|     ..||.....: .|..|.:  .|:||..|.:.|... :..
Human   381 KKLESFYIQKVLDIIATINKG-----SIVWQEVFDDKAKLAPGT--IVEVWKDSAYPEELSRVTA 438

  Fly   533 NGYNVIFSHVDAWYLD-CGFGSWRATGDAACAPYRTWQNVYKHRPWERMRLD----KKRKKQVLG 592
            :|:.||.|  ..|||| ..:|             :.|:..||..|     ||    :|:|:..:|
Human   439 SGFPVILS--APWYLDLISYG-------------QDWRKYYKVEP-----LDFGGTQKQKQLFIG 483

  Fly   593 GEVCMWTEQVDENQLDNRLWPRTAALAERLWTDPSDDHDMDIVPPDVFRRISLFRNRLVELGIRA 657
            ||.|:|.|.||...|..|||||.:|:.||||:. .|..|||    |.:.|::..|.|:||.||.|
Human   484 GEACLWGEYVDATNLTPRLWPRASAVGERLWSS-KDVRDMD----DAYDRLTRHRCRMVERGIAA 543

  Fly   658 EALFPKYC 665
            :.|:..||
Human   544 QPLYAGYC 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fdl	NP_725178.2	Glycohydro_20b2	110..265	CDD:291511	39/171 (23%)
		GH20_HexA_HexB-like	289..654	CDD:119332	133/384 (35%)
HEXB	NP_000512.2	Glycohydro_20b2	56..178	CDD:317278	39/171 (23%)
		GH20_HexA_HexB-like	200..540	CDD:119332	133/384 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146987
Domainoid	1	1.000	204	1.000	Domainoid score	I2952
eggNOG	1	0.900	-	-		E1_COG3525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3379
Isobase	1	0.950	-	0	Normalized mean entropy	S4676
OMA	1	1.010	-	-		QHG54329
OrthoDB	1	1.010	-	-		D164123at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8586
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22600
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2560
SonicParanoid	1	1.000	-	-		X846
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.890