Protein Alignment fdl and HEXA

DIOPT Version :9

• Sequence 1: NP_725178.2
• Gene: fdl / 250735
• FlyBaseID: FBgn0045063
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_001305754.1
• Gene: HEXA / 3073
• HGNCID: 4878
• Length: 540
• Species: Homo sapiens
• Alignment Length: 597
• Identity: 173/597 - (28%)
• Similarity: 262/597 - (43%)
• Gaps: 123/597 - (20%)

  Fly   110 IWPHPTQKFLLSSQTHSFSVEDVQLHVDTAHREVRKQLQLAFDWFLKDLRLIQRLDYVGSSSEPT 174
            :||.| |.|..|.|.:.....:.|...|                             |.|:::|.
Human    23 LWPWP-QNFQTSDQRYVLYPNNFQFQYD-----------------------------VSSAAQPG 57

  Fly   175 VSESSSKSRHHADLEPAATLFGA-----------------TFGVKKAGDLTSVQVKISVLKSGDL 222
            .|......:.:.||     |||:                 .| :.|...|....:.:||:..|..
Human    58 CSVLDEAFQRYRDL-----LFGSGSWPRPYLTGWPHQAYPVF-LGKRHTLEKNVLVVSVVTPGCN 116

  Fly   223 NF-SLDNDETYQLSTQTEGHRLQVEIIANSYFGARHGLSTLQQLIWFDDEDHLLHTYAN-SKVKD 285
            .. :|::.|.|.|:...:    |..:::.:.:||..||.|..||:|...|...   :.| ::::|
Human   117 QLPTLESVENYTLTINDD----QCLLLSETVWGALRGLETFSQLVWKSAEGTF---FINKTEIED 174

  Fly   286 APKFRYRGLMLDTSRHFFSVESIKRTIVGMGLAKMNRFHWHLTDAQSFPYISRYYPELAVHGAYS 350
            .|:|.:|||:||||||:..:.||..|:..|...|:|.|||||.|..||||.|..:|||...|:|:
Human   175 FPRFPHRGLLLDTSRHYLPLSSILDTLDVMAYNKLNVFHWHLVDDPSFPYESFTFPELMRKGSYN 239

  Fly   351 E-SETYSEQDVREVAEFAKIYGVQVIPEIDAPAHAGNGWDWGPKRGM-GELAMCINQQPWSFYCG 413
            . :..|:.|||:||.|:|::.|::|:.|.|.|.|.   ..|||  |: |.|..|        |.|
Human   240 PVTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHT---LSWGP--GIPGLLTPC--------YSG 291

  Fly   414 EPPC---GQLNPKNNYTYLILQRIYEELLQHTGPTDFFHLGGDEVNLDCWAQYFNDTDL---RGL 472
            ..|.   |.:||..|.||..:...:.| :....|..:.|||||||:..||.......|.   :|.
Human   292 SEPSGTFGPVNPSLNNTYEFMSTFFLE-VSSVFPDFYLHLGGDEVDFTCWKSNPEIQDFMRKKGF 355

  Fly   473 WCD------FMLQAMARLKLANNGVAPKHVAVWSSALTN-TKCLPNSQFTVQVWGGS---TWQEN 527
            ..|      |.:|.:..: :::.|   |...||.....| .|..|::  .:|||...   .:.:.
Human   356 GEDFKQLESFYIQTLLDI-VSSYG---KGYVVWQEVFDNKVKIQPDT--IIQVWREDIPVNYMKE 414

  Fly   528 YDLLDN-GYNVIFSHVDAWYLD-CGFGSWRATGDAACAPYRTWQNVYKHRPWERMRLDKKRKKQV 590
            .:|:.. |:..:.|  ..|||: ..:|.             .|::.|...|. ......::|..|
Human   415 LELVTKAGFRALLS--APWYLNRISYGP-------------DWKDFYIVEPL-AFEGTPEQKALV 463

  Fly   591 LGGEVCMWTEQVDENQLDNRLWPRTAALAERLWTDPSDDHDMDIVPPDVFRRISLFRNRLVELGI 655
            :|||.|||.|.||...|..|||||..|:|||||::.... |:..    .:.|:|.||..|:..|:
Human   464 IGGEACMWGEYVDNTNLVPRLWPRAGAVAERLWSNKLTS-DLTF----AYERLSHFRCELLRRGV 523

  Fly   656 RAEALFPKYCAQ 667
            :|:.|...:|.|
Human   524 QAQPLNVGFCEQ 535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fdl	NP_725178.2	Glycohydro_20b2	110..265	CDD:291511	34/172 (20%)
		GH20_HexA_HexB-like	289..654	CDD:119332	127/384 (33%)
HEXA	NP_001305754.1	Glycohydro_20b2	23..156	CDD:291511	34/172 (20%)
		GH20_HexA_HexB-like	178..522	CDD:119332	127/384 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146989
Domainoid	1	1.000	204	1.000	Domainoid score	I2952
eggNOG	1	0.900	-	-		E1_COG3525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3379
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54329
OrthoDB	1	1.010	-	-		D164123at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8586
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22600
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2560
SonicParanoid	1	1.000	-	-		X846
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.940