DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fdl and Hexb

DIOPT Version :9

Sequence 1:	NP_725178.2	Gene:	fdl / 250735	FlyBaseID:	FBgn0045063	Length:	673	Species:	Drosophila melanogaster
Sequence 2:	NP_034552.1	Gene:	Hexb / 15212	MGIID:	96074	Length:	536	Species:	Mus musculus

Alignment Length:	563	Identity:	183/563 - (32%)
Similarity:	266/563 - (47%)	Gaps:	105/563 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 QLQLAFDWFLKDLRLIQRLDYVGS-------SSEPTVSESSS----------------KSRHHAD 187
            :||.|...|.:.:::..||.|:.:       |...|...|.|                ..|||.
Mouse    30 RLQPALWPFPRSVQMFPRLLYISAEDFSIDHSPNSTAGPSCSLLQEAFRRYYNYVFGFYKRHHG- 93

  Fly   188 LEPAATLFGATFGVKKAGDLTSVQVKISVLKSGDLNF-SLDNDETYQLSTQTEGHRLQVEII-AN 250
              ||.  |.|...::|.  |.|:     .|:|...:| ||.:||||.|..|.     .|.:: ||
Mouse    94 --PAR--FRAEPQLQKL--LVSI-----TLESECESFPSLSSDETYSLLVQE-----PVAVLKAN 142

  Fly   251 SYFGARHGLSTLQQLIWFDDEDHLLHTYANSKVKDAPKFRYRGLMLDTSRHFFSVESIKRTIVGM 315
            |.:||..||.|..||::.|...  ..|...|.:.|:|:|.:||:::||||||..|::|.:|:..|
Mouse   143 SVWGALRGLETFSQLVYQDSFG--TFTINESSIADSPRFPHRGILIDTSRHFLPVKTILKTLDAM 205

  Fly   316 GLAKMNRFHWHLTDAQSFPYISRYYPELAVHGAYSESETYSEQDVREVAEFAKIYGVQVIPEIDA 380
            ...|.|..|||:.|.|||||.|..:|||:..|:||.|..|:..|||.|.|:|::.|::||||.|.
Mouse   206 AFNKFNVLHWHIVDDQSFPYQSTTFPELSNKGSYSLSHVYTPNDVRMVLEYARLRGIRVIPEFDT 270

  Fly   381 PAHAGNGWDWGPKRGMGELAMCINQQPWSFYCGEPPCGQLNPKNNYTYLILQRIYEELLQHTGPT 445
            |.|. ..|..|.|   ..|..|.||:..:     ...|.::|..|.||......::| :....|.
Mouse   271 PGHT-QSWGKGQK---NLLTPCYNQKTKT-----QVFGPVDPTVNTTYAFFNTFFKE-ISSVFPD 325

  Fly   446 DFFHLGGDEVNLDCWAQYFNDTDL---RGLWCDF----------MLQAMARLKLANNGVAPKHVA 497
            .|.|||||||...|||...|....   :|...||          :|:.::.||        |:..
Mouse   326 QFIHLGGDEVEFQCWASNPNIQGFMKRKGFGSDFRRLESFYIKKILEIISSLK--------KNSI 382

  Fly   498 VWSSALTN-TKCLPNSQFTVQVWGGSTWQENYDL---LDNGYNVIFSHVDAWYLD-CGFGSWRAT 557
            ||.....: .:..|.:  .|:||....:  :|:|   ..:|:..|.|  ..|||| ..:|
Mouse   383 VWQEVFDDKVELQPGT--VVEVWKSEHY--SYELKQVTGSGFPAILS--APWYLDLISYG----- 436

  Fly   558 GDAACAPYRTWQNVYKHRPWERMRLDKKRKKQVLGGEVCMWTEQVDENQLDNRLWPRTAALAERL 622
                    :.|:|.||..|. .....:|:|:.|:|||.|:|.|.||...|..|||||.:|:.|||
Mouse   437 --------QDWKNYYKVEPL-NFEGSEKQKQLVIGGEACLWGEFVDATNLTPRLWPRASAVGERL 492

  Fly   623 WTDPSDDHDMDIVPPDVFRRISLFRNRLVELGIRAEALFPKYC 665
            |: |....|::    :.::|:::.|.|:|..||.|:.|:..||
Mouse   493 WS-PKTVTDLE----NAYKRLAVHRCRMVSRGIAAQPLYTGYC 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fdl	NP_725178.2	Glycohydro_20b2	110..265	CDD:291511	41/143 (29%)
fdl	NP_725178.2	GH20_HexA_HexB-like	289..654	CDD:119332	129/382 (34%)
Hexb	NP_034552.1	Glycohydro_20b2	35..157	CDD:291511	38/138 (28%)
Hexb	NP_034552.1	GH20_HexA_HexB-like	179..519	CDD:119332	129/382 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836933
Domainoid	1	1.000	198	1.000	Domainoid score	I3073
eggNOG	1	0.900	-	-		E1_COG3525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	240	1.000	Inparanoid score	I3330
Isobase	1	0.950	-	0	Normalized mean entropy	S4676
OMA	1	1.010	-	-		QHG54329
OrthoDB	1	1.010	-	-		D164123at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8815
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22600
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2560
SonicParanoid	1	1.000	-	-		X846
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.890