DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hk1 and Hex-A

DIOPT Version :9

Sequence 1:	NP_001380640.1	Gene:	Hk1 / 25058	RGDID:	2796	Length:	922	Species:	Rattus norvegicus
Sequence 2:	NP_524848.1	Gene:	Hex-A / 45875	FlyBaseID:	FBgn0001186	Length:	541	Species:	Drosophila melanogaster

Alignment Length:	453	Identity:	213/453 - (47%)
Similarity:	299/453 - (66%)	Gaps:	14/453 - (3%)

- Green bases have known domain annotations that are detailed below.

  Rat   468 AEQHRQIEETLAHFRLSKQTLMEVKKRLRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHGDF 532
            ||:.:.:.|......|:.:.:.|:..|:..|:..||.|:|:.||.||...::|:.:|:|.|.|.|
  Fly    89 AEKSKMVHELCQQLLLTDEQVQELCYRILHELRRGLAKDTHPKANVKCFVTYVQDLPNGNERGKF 153

  Rat   533 LALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISDFLDYMGIKG 597
            ||||||||||||||:.::  :....:|.::||:||..||.|:|.:|||||..|:|:|:....:..
  Fly   154 LALDLGGTNFRVLLIHLQ--ENNDFQMESRIYAIPQHIMIGSGTQLFDHIAECLSNFMAEHNVYK 216

  Rat   598 PRMPLGFTFSFPCHQTNLDCGILISWTKGFKATDCEGHDVASLLRDAVKRREEFDLDVVAVVNDT 662
            .|:|||||||||..|..|..|:|.:|||||........||..||:||:.||.:..:||.|::|||
  Fly   217 ERLPLGFTFSFPLRQLGLTKGLLETWTKGFNCAGVVNEDVVQLLKDAIARRGDVQIDVCAILNDT 281

  Rat   663 VGTMMTCAYEEPTCEIGLIVGTGTNACYMEEMKNVEMV---EGNQGQMCINMEWGAFGDNGCLDD 724
            .||:|:||::...|:||||||||.||||||.::..|:.   :..:..:.||.|||||||||.||.
  Fly   282 TGTLMSCAWKNHNCKIGLIVGTGANACYMERVEEAELFAAEDPRKKHVLINTEWGAFGDNGALDF 346

  Rat   725 IRTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRGIFETK 789
            :||:||:.:|.:|:|.|||.|||||||||:||:||.:|:..|:.|.||.||.||.|.|||:|.||
  Fly   347 VRTEFDRDIDVHSINPGKQTFEKMISGMYMGELVRLVLVKMTQAGILFNGQDSEVLNTRGLFFTK 411

  Rat   790 FLSQIESDRLA-LLQVRAILQQLGL-NSTCDDSILVKTVCGVVSKRAAQLCGAGMAAVVEKIREN 852
            ::|:||:|... ....|.:|::||| |:|..|...|:.:|..||||||.|..||:|.::.|
  Fly   412 YVSEIEADEPGNFTNCRLVLEELGLTNATDGDCANVRYICECVSKRAAHLVSAGIATLINK---- 472

  Rat   853 RGLDHLNVTVGVDGTLYKLHPHFSRIMHQTVKEL-SPKCTVSFLLSEDGSGKGAALITAVGVR 914
              :|...|||||||::|:.||.|..:|.:.:.:| .|..|...:|||||||:||||:.||..|
  Fly   473 --MDEPTVTVGVDGSVYRFHPKFHNLMVEKISQLIKPGITFDLMLSEDGSGRGAALVAAVACR 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hk1	NP_001380640.1	PTZ00107	23..464	CDD:240270
		Hexokinase_1	473..671	CDD:395278	87/197 (44%)
		Hexokinase_2	677..911	CDD:397683	119/239 (50%)
Hex-A	NP_524848.1	Hexokinase_1	95..290	CDD:395278	87/196 (44%)
Hex-A	NP_524848.1	Hexokinase_2	296..530	CDD:397683	119/239 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	229	1.000	Domainoid score	I2383
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H100530
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	1	1.000	-	-		mtm9035
orthoMCL	1	0.900	-	-		OOG6_100418
Panther	1	1.100	-	-	O	PTHR19443
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X170
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.920