DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Camk4 and CG10177

DIOPT Version :9

Sequence 1:	NP_036859.2	Gene:	Camk4 / 25050	RGDID:	2264	Length:	474	Species:	Rattus norvegicus
Sequence 2:	NP_651150.1	Gene:	CG10177 / 42772	FlyBaseID:	FBgn0039083	Length:	411	Species:	Drosophila melanogaster

Alignment Length:	265	Identity:	76/265 - (28%)
Similarity:	129/265 - (48%)	Gaps:	17/265 - (6%)

- Green bases have known domain annotations that are detailed below.

  Rat    41 FFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTV---DKKIVRTEIGVLLRL-SHPNIIKLK 101
            :.|....:.....:::||.:.:..:....:|::.|..   |:.....|..||.:| ||||||:|.
  Fly   148 YIETIEPVEHNTRTLIYRGQTRANRTKCTVKMVNKQTQSNDRGDTYMEAEVLRQLQSHPNIIELM 212

  Rat   102 EIFETPTEISLVLELVTGGELFDRIVEK-GYYSERDAADAVKQILEAVAYLHENGIVHRDLKPEN 165
            ...|....:..|||.:...  ..::::| |..||.||...::..:.|:|::|:..::|||:||||
  Fly   213 YTVEDERYMYTVLEHLDCN--MQKVIQKRGILSEADARSVMRCTVSALAHMHQLQVIHRDIKPEN 275

  Rat   166 LLYATPAPD---APLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIIT 227
            ||..:.:..   ..:|:|:|.|:.......|. ..||||.|.|||::....|..:||.||:|:..
  Fly   276 LLVCSSSGKWNFKMVKVANFDLATYYRGSKLY-VRCGTPCYMAPEMIAMSGYDYQVDSWSLGVTL 339

  Rat   228 YILLCGFEPFYDE-RGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVKKLIVLDPKKR-----LT 286
            :.:|||..||... :..:.::..|::....:.......:|..|..|:..|:|.||..|     |.
  Fly   340 FYMLCGKMPFASACKNSKEIYAAIMSGGPTYPKDMESVMSPEATQLIDGLLVSDPSYRVPIAELD 404

  Rat   287 TFQAL 291
            .||.|
  Fly   405 KFQFL 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Camk4	NP_036859.2	STKc_CaMKIV	38..331	CDD:270987	76/265 (29%)
		Autoinhibitory domain	297..336
		PP2A-binding. /evidence=ECO:0000250	302..319
		Calmodulin-binding. /evidence=ECO:0000255	318..337
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	336..474
CG10177	NP_651150.1	DCX	18..108	CDD:214711
		S_TKc	164..409	CDD:214567	74/247 (30%)
		PKc_like	164..403	CDD:304357	71/241 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900