DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prkcb and Pkcdelta

DIOPT Version :9

Sequence 1:	NP_036845.3	Gene:	Prkcb / 25023	RGDID:	3396	Length:	673	Species:	Rattus norvegicus
Sequence 2:	NP_572797.3	Gene:	Pkcdelta / 32191	FlyBaseID:	FBgn0259680	Length:	1894	Species:	Drosophila melanogaster

Alignment Length:	518	Identity:	224/518 - (43%)
Similarity:	292/518 - (56%)	Gaps:	49/518 - (9%)

- Green bases have known domain annotations that are detailed below.

  Rat   193 DPYVKLKLIPDPKSESKQKTK--TIKCSLNPEWNETFRFQLKESDKDRRLSVE------IWDWDL 249
            ||:.|:|:....|...|::..  .:..:..|.|.........|:..|...|.|      ..|.|.
  Fly  1373 DPHKKIKIDTTNKCYVKEEAPRYPLVATPRPLWKREKIVYSDENTDDESGSEEGSGGSLDEDSDD 1437

  Rat   250 TSRNDFMGSLSFGISE--------LQKAGVDGWFKLLSQEEGEYFN-----VPVPPEGSEGNEEL 301
            .|..:...|.|...|.        :.|||......:|........|     ||....||.|....
  Fly  1438 ESGGEECSSTSSSASSEDLDAVAMVTKAGSSNATTVLDSSNSSGSNAGTLSVPSAGSGSGGGAST 1502

  Rat   302 RQKFERAKIG--------QGTKAPEE-----KTANTISKFDNNGN-------RDRMK---LTDFN 343
            .......::.        :|..||..     :|:.|.|:|..:|.       ..|.|   :.||:
  Fly  1503 SSSPSIIRMSTCSNDSGFEGGTAPSSPKKMLETSYTYSQFQKSGRFTAPATVIPRFKNYSVDDFH 1567

  Rat   344 FLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHS 408
            ||.||||||||||:|:|.:.|...||:|.||||||::||||:.|::|::||||..|.|:|..|..
  Fly  1568 FLAVLGKGSFGKVLLAELRDTTYYYAIKCLKKDVVLEDDDVDSTLIERKVLALGTKHPYLCHLFC 1632

  Rat   409 CFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVM 473
            .|||...|:|||||:||||||:|||:.|||.|..|.||.|||..||.||..|||||||||||||:
  Fly  1633 TFQTESHLFFVMEYLNGGDLMFHIQESGRFSEERARFYGAEIISGLKFLHKKGIIYRDLKLDNVL 1697

  Rat   474 LDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQ 538
            ||.|||::||||||||..|:...|..:|||||||:|||||..:.|.::||||:|||||||||.||
  Fly  1698 LDYEGHVRIADFGMCKLQIYLDKTADSFCGTPDYMAPEIIKGEKYNQNVDWWSFGVLLYEMLIGQ 1762

  Rat   539 APFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGC--GPEGERDIKEHAFFR 601
            :||.|.||||||.||......:|..:|.||..|.|||:.|...||:|.  .|.|  ||.:|.|||
  Fly  1763 SPFSGCDEDELFWSICNEIPWFPVYISAEATGILKGLLEKDYTKRIGSQYSPAG--DIADHIFFR 1825

  Rat   602 YIDWEKLERKEIQPPYKPKA-CGRNAENFDRFFTRHPPVLTPPDQEVIRNIDQSEFEGFSFVN 663
            .|||..||:::|:||:||:. ...:.:.|||.|||....|||.|:|::.::||.:|.||::.|
  Fly  1826 PIDWGLLEKRQIEPPFKPQVKHPLDTQYFDRVFTRERVRLTPIDKEILASMDQKQFHGFTYTN 1888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prkcb	NP_036845.3	C1_1	37..89	CDD:278556
		C1_1	102..152	CDD:278556
		C2_PKC_alpha_gamma	159..289	CDD:175992	23/116 (20%)
		STKc_cPKC_beta	341..663	CDD:270767	185/324 (57%)
		S_TKc	342..600	CDD:214567	155/259 (60%)
Pkcdelta	NP_572797.3	S_TKc	1566..1824	CDD:214567	155/259 (60%)
Pkcdelta	NP_572797.3	STKc_nPKC_theta_like	1570..1889	CDD:270744	182/321 (57%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343123
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D143719at33208
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X125
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850