Protein Alignment Xrcc6 and Irbp

DIOPT Version :10

• Sequence 1: NP_620780.2
• Gene: Xrcc6 / 25019
• RGDID: 2643
• Length: 608
• Species: Rattus norvegicus
• Sequence 2: NP_536773.1
• Gene: Irbp / 117419
• FlyBaseID: FBgn0011774
• Length: 631
• Species: Drosophila melanogaster
• Alignment Length: 662
• Identity: 166/662 - (25%)
• Similarity: 305/662 - (46%)
• Gaps: 86/662 - (12%)

  Rat     1 MSEWESYYKTE---GEEEEEEEQSPDTNGEYKYSGRDSLIFLVDASRAMFESQGEDELTPFDMSI 62
            ||.|......:   |.|:||     |.:.:..|.||::::|:|||:   .::.|.:.|..   ::
  Fly     1 MSTWNPENDVDLLSGSEDEE-----DVSMKRDYHGREAILFVVDAN---LQTAGVERLLE---AL 54

  Rat    63 QCIQSVYTSKIISSDRDLLAVVFYGTEKD---------KNSV---NFKSIYVLQDLDNPGAKRVL 115
            ..|::.:.|.::.:|:||:.::|..|:..         .|.|   |......|:.|..|..:..|
  Fly    55 NIIRTAFISGLLVNDKDLIGLIFANTKHSPPPLEASALDNIVMPDNCAVFLPLRQLTKPIVEHYL 119

  Rat   116 ELDRFKGQQGKKHFRDTIGHGSDYSLSE---------VLWVCANLFSDVQFKMSHKRIMLFTNED 171
            |   |.|.. :..|.|.      |.|:|         ::.:|..:......|:::.:|...|:..
  Fly   120 E---FMGGV-ETQFADV------YGLAEPDGRGRFDLMIRLCIEMLEKCGKKLNNAKIAYVTDVR 174

  Rat   172 DPHGNDSAKASRARTKASDLRDTGIFLDLMHLKKRGGFDVSLFYRDIISIAEDEDL-GVHFEESS 235
            :||.::|.....|..|||||.  |...:...:.....||...||::.|:::...:| .....::.
  Fly   175 EPHPSNSNHFQAALQKASDLE--GKEFEFHVIPMVDDFDYEPFYKEFITLSRAIELDAFQVPDAQ 237

  Rat   236 KLEDLL--RKVRAKETKKRVLSRLKFKLGKDVALMVGVYNLVQKANKPFPVRLYRETNEPVKTKT 298
            .|.::|  ||:: ::..:|.|....|.||.::::.|..||..|:...|..|::.|..|..|:||
  Fly   238 MLREILSDRKLK-QDFLRRCLGHFSFYLGPNLSMSVQYYNYFQRRAYPRKVQILRRDNSVVRTK- 300

  Rat   299 RTFNV----NTGSLLLPSDTKRSLT-------FGTRQIVLEKEETEELKRFDEPGLILMGFKPMV 352
            |...|    :.||..:..:.:..:|       .|.|.:.:..::...::...:|.::|:|||...
  Fly   301 RVITVQKQKDDGSQDIEHEYQIKVTGGWYTCNVGERDLRISMDQLNRVRNLHKPQMMLLGFKHRS 365

  Rat   353 MLKNHHYLRPSLFLYPEESLVNGSSTLFSALLTKCVEKEVIAVCRYTARKNVSPYFVALVPQE-- 415
            .|....|::|:.|:||::..:.||..||.||..:|:.::.||:|.:..::...|.:|||||.|
  Fly   366 SLPEVSYIKPANFMYPDDQSIIGSKRLFRALWERCLVRDKIAICLFMCKRKSIPRYVALVPVEAP 430

  Rat   416 EELDDQNIQ--VTPAGFQLVFLPYADDKRKVPF-----TEKVMANPEQIDKMKAIVQKLRFTYRS 473
            :..:|:|.:  :...||::|:||.|...|.:..     ||.. |:.::::..:.|::|||..|:.
  Fly   431 DNGEDKNYRSLLCGDGFKIVYLPEAKHIRHLDLQDWNNTENT-ADEQKVEFFQKIIKKLRVDYQP 494

  Rat   474 DSFENPVLQQHFRNLEALALDMMESEQVVDLTLPKVEAIKKRLGSLADEFKELVYPPGYNPEGKI 538
            :...:|.|.....||.||:||.....:.:|..|...:. .||:..|..:::  ::.|...|..|.
  Fly   495 NLINDPSLDALQANLLALSLDFSTDTKGLDNLLDTSQQ-DKRIEKLLPDYE--MFAPEAEPHKKR 556

  Rat   539 AKRKADNEGSASKKPKVELSEEELKDL-FAKG-----TLGKLTVPALRDICKAYGLKSGPK--KQ 595
            |.:......|..|..|::  :::||:. |.|.     .|...|...|..|.:.:...:.||  |:
  Fly   557 AAKSTTAGASGPKMAKID--DDQLKEFEFVKSLNKDEALTSCTAAQLHFILQHHFDVTMPKSSKK 619

  Rat   596 ELLEALSRHLEK 607
            ..|.|....|.|
  Fly   620 AKLVAKIEELHK 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Xrcc6	NP_620780.2	ku70	22..606	CDD:273151	157/635 (25%)
Irbp	NP_536773.1	Ku_N	33..256	CDD:427470	52/241 (22%)
		KU70	255..546	CDD:238407	81/295 (27%)
		HeH	593..624	CDD:403988	8/30 (27%)