DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo5a and zip

DIOPT Version :9

Sequence 1:XP_038936774.1 Gene:Myo5a / 25017 RGDID:3143 Length:1880 Species:Rattus norvegicus
Sequence 2:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0265434 Length:2056 Species:Drosophila melanogaster


Alignment Length:2021 Identity:549/2021 - (27%)
Similarity:908/2021 - (44%) Gaps:438/2021 - (21%)


- Green bases have known domain annotations that are detailed below.


  Rat     7 YTKFARVWIPDPEEVWKSAELLKDYKPGDKVLLLHLEEGK-------DLEYRLDPKTSELPHLRN 64
            :|:...||:|...:.:.:|.:.:::  ||:|.:...|.||       |::....||..::     
  Fly    76 WTQKRLVWVPHENQGFVAASIKREH--GDEVEVELAETGKRVMILRDDIQKMNPPKFDKV----- 133

  Rat    65 PDILVGENDLTALSYLHEPAVLHNLRVRFIDSKLIYTYCGIVLVAINPYEQLPIYGEDIINAYSG 129
                   .|:..|:.|:|.:||||::.|:. |.|||||.|:..|.:|||::||||.|.|:..|.|
  Fly   134 -------EDMAELTCLNEASVLHNIKDRYY-SGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKG 190

  Rat   130 QNMGDMDPHIFAVAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYFATVSGS-------- 186
            ....::.||:||:.:.||:.|..|..:|||:.:||||||||.:.|..:::.|.|:.|        
  Fly   191 IKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAV 255

  Rat   187 --------------------------------------------ASEANVEEKVLASNPIMESIG 207
                                                        ..|..:|:::|.:|||:|:.|
  Fly   256 PHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFG 320

  Rat   208 NAKTTRNDNSSRFGKYIEIGFDKRYRIIGANMRTYLLEKSRVVFQAEEERNYHIFYQLCASAKLP 272
            ||||.:|||||||||:|.|.||....|.|||:.||||||||.:.||::||.:||||||.|.|...
  Fly   321 NAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPE 385

  Rat   273 EFKMLRLGNADSFHYTKQGGSPMIEGVDDAKEMAHTRQACTLLGISESYQMGIFRILAGILHLGN 337
            :.:...|.:..|:.:...|..| :.||||..|...|.::..::|::......||||::.:|..|:
  Fly   386 QREKFILDDVKSYAFLSNGSLP-VPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGS 449

  Rat   338 VGF-ASRDSDSCTIPPKHEPLIIFCDLMGVDYEEMCHWLCHRKLATATETYIKPISKLQATNARD 401
            :.| ..|::|..|:|.......| ..|:|:...:|.......::....:...|..:|.|...|.:
  Fly   450 MKFRQERNNDQATLPDNTVAQKI-AHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEFAVE 513

  Rat   402 ALAKHIYAKLFNWIVGHVNQALHSAVKQ-HSFIGVLDIYGFETFEINSFEQFCINYANEKLQQQF 465
            |:||..|.::|.|:|..:|::|....:| .||||:||:.|||.||:|||||.||||.||||||.|
  Fly   514 AIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLF 578

  Rat   466 NMHVFKLEQEEYMKEQIPWTLIDF-YDNQPCINLIESKLGILDLLDEECKMPKGTDDTWAQKLYN 529
            |..:|.||||||.:|.|.|..||| .|.||.|:||:...||:.||||||..||.||.|:..||.:
  Fly   579 NHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTFVDKLVS 643

  Rat   530 THLNKCALFEKPRMSNKA-FIIKHFADKVEYQCEGFLEKNKDTVFEEQIKVLKSSKFKMLPELFQ 593
            .| :....|.|......| |.|.|:|.:|:|....:|.||.|.:.|..:.:|:.|:...:..:::
  Fly   644 AH-SMHPKFMKTDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWK 707

  Rat   594 DDE---KAISPTSATSSGRTPLTRVPVKPTKGRPGQTAKEHKKTVGLQFRNSLHLLMETLNATTP 655
            |.|   .|....:.|..|                .:|.|...:||...::..|..||:||..|.|
  Fly   708 DAEIVGMAQQALTDTQFG----------------ARTRKGMFRTVSHLYKEQLAKLMDTLRNTNP 756

  Rat   656 HYVRCIKPNDFKFPFTFDEKRAVQQLRACGVLETIRISAAGFPSRWTYQEFFSRYRVLMKQKDVL 720
            ::||||.||..|.....|....:.|||..||||.|||...|||:|..:|||..||.:|.......
  Fly   757 NFVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPK 821

  Rat   721 G--DRKQTCQNVLEKLILDKDKYQFGKTKIFFRAGQVAYLEKLRADKLRAACIRIQKTIRGWLLR 783
            |  |.|:.|:.:::.|.||.:.|:.|::|||||||.:|:||:.|..|:....:..|...||:|.|
  Fly   822 GFMDGKKACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLAR 886

  Rat   784 KRYLCMQRAAITVQRYVRGYQARCYAKFLRRTKAATTIQKYWRMYVVRRKYKIRRAATIVLQSYL 848
            :.|    :..:.....:|..|..|.|....|.      .::||:|.     |::....:..|.  
  Fly   887 RNY----QKRLQQLNAIRIIQRNCAAYLKLRN------WQWWRLYT-----KVKPLLEVTKQE-- 934

  Rat   849 RGYLARNRYRKILREHKAVIIQKRVRGWL------ARTHYKRTMKAIIYLQCCFRRMMAKRELKK 907
                     .|::::...:   |:||..|      .:.:.::..:|::.......::.|:.||..
  Fly   935 ---------EKLVQKEDEL---KQVREKLDTLAKNTQEYERKYQQALVEKTTLAEQLQAEIELCA 987

  Rat   908 LKIEARSVERYKKLHIGMENKIMQLQRKVDEQNKDYKCLMEKLTNLEGVYNSETEKLRNDVERL- 971
            ...|:||....:|..  :|:.:.:|:.:::|:.       |::..|.|    |.:||..:::.| 
  Fly   988 EAEESRSRLMARKQE--LEDMMQELETRIEEEE-------ERVLALGG----EKKKLELNIQDLE 1039

  Rat   972 -QLSEEEA---KVATGRVLSLQEEIAKLRKDL-------EQTRSEKKSIEERADKYKQ---ETEQ 1022
             ||.||||   |:...:| .|..:|.|..:||       ::...|||.:||||:...|   |.|:
  Fly  1040 EQLEEEEAARQKLQLEKV-QLDAKIKKYEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEE 1103

  Rat  1023 LVSNL-----KEENTLLKQEKETLNHLMVEQAKEMTETMERKLVEETKQLELDLNDERLRYQNLL 1082
            ...:|     |.|.|:.:.|:.....   :|.::.::..:||:..|...|:..||:.|::...:.
  Fly  1104 KAKHLAKLKAKHEATISELEERLHKD---QQQRQESDRSKRKIETEVADLKEQLNERRVQVDEMQ 1165

  Rat  1083 NEFSRLEERYDDLKEEMT-LMLNVPKPGHKRTDSTHSSNESEYTFSSEFAE-TEDI-APRTEEPT 1144
            .:.::.|       ||:| .:|.:.:....:..:..:..|.|    |:.|| .||: |.:.....
  Fly  1166 AQLAKRE-------EELTQTLLRIDEESATKATAQKAQRELE----SQLAEIQEDLEAEKAARAK 1219

  Rat  1145 EKKVPLDMSLFLKLQKRVTELEQEKQLMQDELD-----------RKEEQVLRSKAKEEERPQIRG 1198
            .:||..|:|         .|||..|..:.|.||           |::|.....|:.|||.....|
  Fly  1220 AEKVRRDLS---------EELEALKNELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEG 1275

  Rat  1199 AELEYESLKRQELESENKKLKNELNELRKA--LSEKSAPEVTAPGAPAYRVLMEQLTAVSE---- 1257
            ...:......|||.|.|.:|:|    ||||  :.||:...:.|..|.    |..:|.:|:.    
  Fly  1276 VLADMRHKHSQELNSINDQLEN----LRKAKTVLEKAKGTLEAENAD----LATELRSVNSSRQE 1332

  Rat  1258 -------------ELDVRKEEVLILRSQLVSQKEAIQPKDDKNTMTDSTILLEDVQKMKDKGEIA 1309
                         ||.|:..|:...||:|  |::..:.:.:...:|:.   ||:.: :|....:.
  Fly  1333 NDRRRKQAESQIAELQVKLAEIERARSEL--QEKCTKLQQEAENITNQ---LEEAE-LKASAAVK 1391

  Rat  1310 QAYIGLKETNRSSAMDYQELNEDGELWLVYEGLKQANRLLESQ------LQSQKRSHENEAEALR 1368
            .|          |.|:.|              |.:|.:|||.:      |.|:.|..|:|.|||:
  Fly  1392 SA----------SNMESQ--------------LTEAQQLLEEETRQKLGLSSKLRQIESEKEALQ 1432

  Rat  1369 GEIQSLKEENNRQQQLLA----QNLQLPPEARIEASLQHEITRLTNENLYFEELYADDPKKYQSY 1429
            .:::...|.....::.||    |..::..:|..:|.|..|:               ::.||..:.
  Fly  1433 EQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDADLAKEL---------------EEGKKRLNK 1482

  Rat  1430 RISLYKRMI-DLMEQLEKQDKTVRKLKKQLKVFAKKIGELEVGQMENISPGQIIDEPIRPVNIPR 1493
            .|...:|.: :|:.|.::.||:.:|::.:|:   ....|||.             :..:.:.:.:
  Fly  1483 DIEALERQVKELIAQNDRLDKSKKKIQSELE---DATIELEA-------------QRTKVLELEK 1531

  Rat  1494 KEKDFQGML-EYKREDEQKLVKNLILELKPRGVAVNLIPGLPAYILFMCVRHADYLNDDQKVRSL 1557
            |:|:|..:| |.|...||...:....|.:.|.....::         ...|..|...|  |:..|
  Fly  1532 KQKNFDKILAEEKAISEQIAQERDTAEREAREKETKVL---------SVSRELDEAFD--KIEDL 1585

  Rat  1558 LTSTINSIKKVLKKRGDDFETVSFWLSNTCRFLHCLKQYSGEEGFMKHNTSRQNEHCL------- 1615
                 .:.:|.|:...||       |:||                  ..|:.:|.|.|       
  Fly  1586 -----ENKRKTLQNELDD-------LANT------------------QGTADKNVHELEKAKRAL 1620

  Rat  1616 ---------TNFDLAEYRQVLSD--LAIQIYQQLVRVLENILQPMIVSGMLEHETIQGVSGV--K 1667
                     .|.:|.:..|:..|  |.:::..|.:|            ...|.:.:....|.  |
  Fly  1621 ESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALR------------SQFERDLLAKEEGAEEK 1673

  Rat  1668 PTGLRKRTSSIADEGTYTLDSILRQLNSFHSVMCQHGMDPELIKQVVKQMFYIVGAITLNNLLLR 1732
            ..||.|:...:..|    ||...:|..:  :|..:..::.:| |::...|       .::| .::
  Fly  1674 RRGLVKQLRDLETE----LDEERKQRTA--AVASKKKLEGDL-KEIETTM-------EMHN-KVK 1723

  Rat  1733 KDMCSWSKGMQIRYNVSQLEEWLRDKNLMNSGAKETLEPL-------IQA--AQLLQV------- 1781
            :|....:|.:|     :|:::.|||.....: |||.|:.|       ::|  |::||:       
  Fly  1724 EDALKHAKKLQ-----AQVKDALRDAEEAKA-AKEELQALSKEAERKVKALEAEVLQLTEDLASS 1782

  Rat  1782 -------KKKTDDDAEAICSMCNALTTAQIVKVLNLYTPVNEFEERVSVSFIRTIQVRLRDRKDS 1839
                   :.:.|:.||.|.:  ||...:.::.           |:|...:.|.|::..|.:.:.:
  Fly  1783 ERARRAAETERDELAEEIAN--NANKGSLMID-----------EKRRLEARIATLEEELEEEQSN 1834

  Rat  1840 PQLLMD 1845
            .::|:|
  Fly  1835 SEVLLD 1840

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo5aXP_038936774.1 COG5022 7..1275 CDD:227355 429/1394 (31%)
MYSc_Myo5 83..751 CDD:276831 271/728 (37%)
Smc 1157..>1484 CDD:224117 82/367 (22%)
Myo5a_CBD 1506..1880 CDD:271262 71/383 (19%)
zipNP_523860.2 Myosin_N 80..117 CDD:280832 10/38 (26%)
Myosin_head 133..854 CDD:278492 275/752 (37%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 271/728 (37%)
Myosin_tail_1 931..2011 CDD:279860 236/1117 (21%)
Prefoldin 1431..1515 CDD:298833 19/101 (19%)
FAM76 <1847..1926 CDD:292665
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
22.000

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