DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo5a and Mhc

DIOPT Version :9

Sequence 1:XP_038936774.1 Gene:Myo5a / 25017 RGDID:3143 Length:1880 Species:Rattus norvegicus
Sequence 2:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster


Alignment Length:2062 Identity:565/2062 - (27%)
Similarity:923/2062 - (44%) Gaps:389/2062 - (18%)


- Green bases have known domain annotations that are detailed below.


  Rat     4 SELYTKFARVWIPDPEEVWKSAELLKDYK--PGDKVLLLHLEEGKDLEYRLDPKTSELPHLRNPD 66
            |:.|......||||.:|.:    ||.:.|  .|| ::.:.|:.|   |.| |.|:.::..: ||.
  Fly    29 SKPYDSKKSCWIPDEKEGY----LLGEIKATKGD-IVSVGLQGG---EVR-DIKSEKVEKV-NPP 83

  Rat    67 ILVGENDLTALSYLHEPAVLHNLRVRFIDSKLIYTYCGIVLVAINPYEQLPIYGEDIINAYSGQN 131
            ......|:..::.|:.|.||||||.|:. :||||||.|:..||||||::.|:|.......|.|:.
  Fly    84 KFEKIEDMADMTVLNTPCVLHNLRQRYY-AKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKR 147

  Rat   132 MGDMDPHIFAVAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYFATVSGS-------ASE 189
            ..::.|||||:::.||..|..:..|||::::||||||||.:.|..:.|||||..|       .|:
  Fly   148 RNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSK 212

  Rat   190 ANVEEKVLASNPIMESIGNAKTTRNDNSSRFGKYIEIGFDKRYRIIGANMRTYLLEKSRVVFQAE 254
            .::|::|:.:||::|:.|||||.||||||||||:|.|.|....::.||::.||||||:||:.|..
  Fly   213 GSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQS 277

  Rat   255 EERNYHIFYQLCASAKLPEFK--MLRLGNADSFHYTKQGGSPMIEGVDDAKEMAHTRQACTLLGI 317
            .||:||||||: .|..:|..|  .|...|...:|...| |...:..:|||:|.:.|.||..:||.
  Fly   278 LERSYHIFYQI-MSGSVPGVKDICLLTDNIYDYHIVSQ-GKVTVASIDDAEEFSLTDQAFDILGF 340

  Rat   318 SESYQMGIFRILAGILHLGNVGFASRDSDSCTIPPKHEPLIIFCDLMGVDYEEMCHWLCHRKLAT 382
            ::..:..::||.|.::|:|.:.|..|..:........|.......|.|.|..|:...|...::..
  Fly   341 TKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKV 405

  Rat   383 ATETYIKPISKLQATNARDALAKHIYAKLFNWIVGHVNQALHSAVKQHSFIGVLDIYGFETFEIN 447
            ..|...:..:..|.||:..||.|.::.:||.|:|...|:.|.:..|:..|||||||.|||.||.|
  Fly   406 GNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYN 470

  Rat   448 SFEQFCINYANEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDF-YDNQPCINLIESKLGILDLLDE 511
            .|||.|||:.||||||.||.|:|.||||||.:|.|.|..||| .|...||:|||..:|||.:|:|
  Fly   471 GFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGILSILEE 535

  Rat   512 ECKMPKGTDDTWAQKLYNTHLNKCALFEKPRMSNKA-----FIIKHFADKVEYQCEGFLEKNKDT 571
            |...||.||.|:::||.||||.|.|.|:||:.....     |.|.|:|..|.|...|:||||||.
  Fly   536 ESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDP 600

  Rat   572 VFEEQIKVLKSSKFKMLPELFQDDEKAISPTSATSSGRTPLTRVPVKPTKGRPGQTAK--EHKK- 633
            :.:..:...|.|:.|:|.|:|.|        .|..||               .|:.||  ..|| 
  Fly   601 LNDTVVDQFKKSQNKLLIEIFAD--------HAGQSG---------------GGEQAKGGRGKKG 642

  Rat   634 ----TVGLQFRNSLHLLMETLNATTPHYVRCIKPNDFKFPFTFDEKRAVQQLRACGVLETIRISA 694
                ||...::..|:.||.||.:|.||:||||.||:.|.|...|....:.||...||||.|||..
  Fly   643 GGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICR 707

  Rat   695 AGFPSRWTYQEFFSRYRVLMKQ--KDVLGDRKQTCQNVLEKLILDKDKYQFGKTKIFFRAGQVAY 757
            .|||:|..|.:|..||:::..:  :.|..|:|.| :.:::.:.|.:|:|:.|.||:|||||.:..
  Fly   708 KGFPNRMMYPDFKMRYKIMCPKLLQGVEKDKKAT-EIIIKFIDLPEDQYRLGNTKVFFRAGVLGQ 771

  Rat   758 LEKLRADKLRAACIRIQKTIRGWLLRKRY--LCMQRAAI-TVQRYVRGY-QARCYA--KFLRRTK 816
            :|:.|.::|......:|...||:|.||.:  |..||.|: .|||.:|.| |.|.:.  |..::.|
  Fly   772 MEEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVK 836

  Rat   817 AATTIQK----YWRMYVVRRKYKIRRAATIVLQSYLRGYLARNRYRKILREHKAVIIQKRVRGWL 877
            ....:.:    ..|:....:|.:...||.:.::..|....|     |:|.|..|::.........
  Fly   837 PLLNVSRIEDEIARLEEKAKKAEELHAAEVKVRKELEALNA-----KLLAEKTALLDSLSGEKGA 896

  Rat   878 ARTHYKRTMKAIIYLQCCFRRMMAKRELKKLKIEARSVERYKKLHIGMENKIMQLQRKVDEQNKD 942
            .:.:.:|..|           :.|::  ..|:.:.|.::..........|::.|.::|.|::...
  Fly   897 LQDYQERNAK-----------LTAQK--NDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISG 948

  Rat   943 YKCLMEKLTNLE-GVYNSETEKLRNDVERLQLSEE-------------------EAKVATGRVLS 987
            .|   :.:.:|| .|..:|.:|...|.:...|::|                   |....||..|.
  Fly   949 LK---KDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDELINKLNKEKKMQGETNQKTGEELQ 1010

  Rat   988 LQEE----IAKLRKDLEQTRSEKKSIEERADKYKQETEQLVSNLKEENTLLKQEKETLNHLMVEQ 1048
            ..|:    :.|::..||||..|.:...||..|.:.:.|:  |..|.|.. ||..:|.:..| ...
  Fly  1011 AAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEK--SKRKVEGD-LKLTQEAVADL-ERN 1071

  Rat  1049 AKEMTETMERKLVEETKQLELDLNDER---LRYQNLLNEFSRLEERYDDLKEEMTLMLNV-PKPG 1109
            .||:.:|::|| .:|...:...|.||:   |::|..:.|   |:.|.::|:||:...... .|..
  Fly  1072 KKELEQTIQRK-DKELSSITAKLEDEQVVVLKHQRQIKE---LQARIEELEEEVEAERQARAKAE 1132

  Rat  1110 HKRTDSTHSSNESEYTFSSEFAETEDIAPRTEE---PTEKKVPLDMSLFLKLQKRVTELEQEKQL 1171
            .:|.|...              |.|::..|.||   .|..::.|:       :||..||.:.::.
  Fly  1133 KQRADLAR--------------ELEELGERLEEAGGATSAQIELN-------KKREAELSKLRRD 1176

  Rat  1172 MQDELDRKEEQVLRSKAKEEERPQIRGAELEYESLKRQELESENKKLKNE----LNELRKAL--- 1229
            :::...:.|..:...:.|..:..    ||:..:..:..:|:::.:|.|||    ||:||..:   
  Fly  1177 LEEANIQHESTLANLRKKHNDAV----AEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHI 1237

  Rat  1230 -SEKSAPEVTAPGAPAYRVLMEQLTAVSEEL----------DVRKEEVLILRSQLVSQKEAIQPK 1283
             :||:|.|..|      :.|...|..|..:|          |..|:::.|..|.|:.|.|..:.:
  Fly  1238 TNEKAAQEKIA------KQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQ 1296

  Rat  1284 DDK--NTMTDSTILLEDVQKMKDKGEIAQAYI------------GLKETNRSSAMDYQEL----- 1329
            ..:  ......|..|||.:::.|:....:|.:            .|:|.....|....:|     
  Fly  1297 VSQLSKIKISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLS 1361

  Rat  1330 --NEDGELW-LVYEG--------LKQANRLLESQLQSQKRSHEN----------EAEALRGEIQS 1373
              |.:.::| ..||.        |::|.|.|:::|...:.:.|:          ..:.|..|::.
  Fly  1362 KANAEAQVWRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVED 1426

  Rat  1374 LKEENNR--------------------QQQLLAQNLQLPPEARIEASLQHEITRLTNENLYFEEL 1418
            |:.|.:|                    :.:|...:|    .|.::|| |.|....:.|....:..
  Fly  1427 LQLEVDRANAIANAAEKKQKAFDKIIGEWKLKVDDL----AAELDAS-QKECRNYSTELFRLKGA 1486

  Rat  1419 YADDPKKYQSYR---ISLYKRMIDLMEQLEKQDKTVRKLKKQLKVFAKKIGELEVG--------- 1471
            |.:..::.::.|   .:|...:.||::|:.:..:.:.:::|..|....:..||:..         
  Fly  1487 YEEGQEQLEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALE 1551

  Rat  1472 QMEN------ISPGQIIDEPIRPVNIPRKEKDFQGMLEYKREDEQKLVKNLILELKPRGVAVNLI 1530
            |.||      :...|:..|..|  .|..||::|:...:..:.....:..:|..|.|.:..|:.:.
  Fly  1552 QEENKVLRAQLELSQVRQEIDR--RIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMK 1614

  Rat  1531 PGLPAYI--LFMCVRHADYLN-DDQKVRSLLTSTINSIKKVLKKRGDDFETVSFWLSNTCRFLHC 1592
            ..|.|.|  |.:.:.||:..| :.||........:..|:..|::                     
  Fly  1615 KKLEADINELEIALDHANKANAEAQKNIKRYQQQLKDIQTALEE--------------------- 1658

  Rat  1593 LKQYSGEEGFMKHNTSRQNEHCLTNFDLAEYRQVLSDL---AIQIYQQLVRVLENILQPMIVSGM 1654
             :|.:.::...:...|.:..:.|.| :|.|.|.:|...   ..|..|:|...             
  Fly  1659 -EQRARDDAREQLGISERRANALQN-ELEESRTLLEQADRGRRQAEQELADA------------- 1708

  Rat  1655 LEHETIQGVSGVKPTGLRKRTSSIADEGTYTLDSILRQLNSFHSVMCQHGMDPELIKQVVKQMFY 1719
              ||.:..||.        :.:||: .....|:|.|:.|:|....:.....:.|  ::..|.|  
  Fly  1709 --HEQLNEVSA--------QNASIS-AAKRKLESELQTLHSDLDELLNEAKNSE--EKAKKAM-- 1758

  Rat  1720 IVGAITLNNLL------------LRKDMCSWSKGMQIRYN-------------VSQLEEWLRD-- 1757
             |.|..|.:.|            |||.:....|.:|:|.:             :.:||:.:|:  
  Fly  1759 -VDAARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELE 1822

  Rat  1758 --------------KNLMNSGAK---------------ETLEPLI-QAAQLLQVKKKTDDDAEAI 1792
                          |||..|..:               |.::.|: :..|.::..|:..::||.|
  Fly  1823 NELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEI 1887

  Rat  1793 CSMCNALTTAQIVKVLNLYTPVNEFEERVSVSFIRTIQVRLRDRKDS 1839
            .::       .:.|.......:.|.|||..::.....:.|.:.|..|
  Fly  1888 AAL-------NLAKFRKAQQELEEAEERADLAEQAISKFRAKGRAGS 1927

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo5aXP_038936774.1 COG5022 7..1275 CDD:227355 437/1352 (32%)
MYSc_Myo5 83..751 CDD:276831 282/691 (41%)
Smc 1157..>1484 CDD:224117 80/422 (19%)
Myo5a_CBD 1506..1880 CDD:271262 72/397 (18%)
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 15/45 (33%)
MYSc 81..777 CDD:214580 291/722 (40%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 282/691 (41%)
Myosin_tail_1 842..1897 CDD:279860 228/1180 (19%)
V_Alix_like 1557..1877 CDD:187408 67/373 (18%)
ATP-synt_B <1671..1771 CDD:304375 28/129 (22%)
TMPIT 1739..>1825 CDD:285135 16/90 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.910

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