DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vars1 and eEF1gamma

DIOPT Version :9

Sequence 1:	NP_445744.1	Gene:	Vars1 / 25009	RGDID:	3950	Length:	1264	Species:	Rattus norvegicus
Sequence 2:	NP_001189308.1	Gene:	eEF1gamma / 44791	FlyBaseID:	FBgn0029176	Length:	431	Species:	Drosophila melanogaster

Alignment Length:	468	Identity:	127/468 - (27%)
Similarity:	190/468 - (40%)	Gaps:	103/468 - (22%)

- Green bases have known domain annotations that are detailed below.

  Rat     4 LYVSPHPDAFPSLRALIAARYGEA----GDGPGWGGPHPRICLQPPPSSR--TPFPPPRLPALEQ 62
            ||.  :|:.|.:.:|||||:|..|    .|...:|        :...|:.  ..||..::||.|.
  Fly     6 LYT--YPENFRAYKALIAAQYSGAQVKVADNFKFG--------ETNKSAEFLKKFPGGKVPAFET 60

  Rat    63 GPGGLWVWGAPAVAQLLWPAGLGGPGGSRAAVLVQQWVSYADTELTPAACGATLPALGLRGPGQD 127
            .. |.::..:.|:|.||....|.|.........||||:|:||.|:.||:|....|.||:. |.|.
  Fly    61 AE-GQYLSESNAIAYLLANEQLRGGKCPFVQAQVQQWISFADNEIVPASCAWVFPLLGIL-PQQK 123

  Rat   128 PQAALGALGKALNPLEEWLRLHTYLAGDAPTLADLAAVTALLLPFRYVLDPSARRIWGNVTRWFN 192
            ...|.......|..|.:.|:..|:|||:..||||:...::||..:.|||:||.|..:|||.|||.
  Fly   124 NSTAKQEAEAVLQQLNQKLQDATFLAGERITLADIVVFSSLLHLYEYVLEPSVRSAFGNVNRWFV 188

  Rat   193 TCVRQPEFRAVLGEVVLYSGARSVTQQPGSEITA------PQKTAAQLKKEAKKREKLEKFQQKQ 251
            |.:.|.:.:||:.:..|...|.....:..:|..|      ||:.|.|.|:|.|.:||.|..::..
  Fly   189 TILNQKQVQAVVKDYKLCEKALVFDPKKYAEFQAKTGAAKPQQQAQQQKQEKKPKEKKEAPKKAA 253

  Rat   252 KTQQQQPAHGEK-KPKPEKKEKRD---PGVITYDLPTPPGEKKDVSGTMPDSYSPQYVEAAWYPW 312
            :..::..|..|. ..:|:.|:..|   .|...:|........:|.:.::|  |.....:|..|..
  Fly   254 EPAEELDAADEALAAEPKSKDPFDALPKGTFNFDDFKRVYSNEDEAKSIP--YFFDKFDAENYSI 316

  Rat   313 WERQGFFKPEYGRPSVSAPNPRGVFMMCIPPPNVTGSLHLGHALTNAIQDSLTRWHRMR------ 371
            |..:..:..|..:          |||.|                 |.|.....|..:||
  Fly   317 WFGEYKYNEELSK----------VFMSC-----------------NLITGMFQRLDKMRKAAFAS 354

  Rat   372 -------GETTLWNPGCDHAGIATQVVVEKKLWKERGLNRHQLGREAFL--------QEVWKWKA 421
                   |.:|:       :||          |..||.:.      ||.        .||:.||
  Fly   355 VCLFGEDGNSTI-------SGI----------WVWRGQDL------AFTLSPDWQIDYEVYDWK- 395

  Rat   422 EKGDRIYHQLKKL 434
             |.|....:.|||
  Fly   396 -KLDAKSEETKKL 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vars1	NP_445744.1	GstA	<56..203	CDD:223698	54/146 (37%)
		GST_C_family	92..213	CDD:295467	47/120 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	218..296		20/87 (23%)
		PTZ00419	282..1264	CDD:240411	34/174 (20%)
		ValRS_core	335..938	CDD:185677	27/121 (22%)
		'HIGH' region	344..354		0/9 (0%)
		tRNA-synt_1_2	513..640	CDD:290334
		'KMSKS' region	862..866
		Anticodon_Ia_Val	938..1075	CDD:153416
		Val_tRNA-synt_C	1196..1258	CDD:287436
eEF1gamma	NP_001189308.1	GST_N_EF1Bgamma	4..79	CDD:239342	24/83 (29%)
		GstA	5..187	CDD:223698	66/192 (34%)
		GST_C_EF1Bgamma_like	90..209	CDD:198290	47/119 (39%)
		EF1G	271..376	CDD:279041	27/150 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0625
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810