DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vars1 and GstE10

DIOPT Version :9

Sequence 1:	NP_445744.1	Gene:	Vars1 / 25009	RGDID:	3950	Length:	1264	Species:	Rattus norvegicus
Sequence 2:	NP_001286570.1	Gene:	GstE10 / 37105	FlyBaseID:	FBgn0063499	Length:	240	Species:	Drosophila melanogaster

Alignment Length:	193	Identity:	43/193 - (22%)
Similarity:	70/193 - (36%)	Gaps:	45/193 - (23%)

- Green bases have known domain annotations that are detailed below.

  Rat     3 ILYVSPHPDAFPSLRALIAARYG------------EAGDGPGWGGPHPRICLQPPPSSRTPFPPP 55
            |||.:   ::.|.:||::.....            :|||       |    |:|....:.  |..
  Fly     5 ILYGT---ESSPPVRAVLLTLRALQLDHEFHTLDMQAGD-------H----LKPDMLRKN--PQH 53

  Rat    56 RLPALEQGPGGLW--------VWGAPAVAQLLWPAGLGGPGGSRAAVLVQQWVSYADTELTPAAC 112
            .:|.||.|...:|        :....|.:..|:|.      ......:|.|.:.:....|.....
  Fly    54 TVPMLEDGESCIWDSHAIIGYLVNKYAQSDELYPK------DPLKRAVVDQRLHFETGVLFHGIF 112

  Rat   113 GATLPALGLRGPGQDPQAALGALGKALNPLEEWLRLHTYLAGDAPTLAD---LAAVTALLLPF 172
            .....||......:.|:..|..|..|...||::|..:.|:||...|:||   :|.|:.|.|.:
  Fly   113 KQLQRALFKENATEVPKDRLAELKDAYALLEQFLAENPYVAGPQLTIADFSIVATVSTLHLSY 175

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vars1	NP_445744.1	GstA	<56..203	CDD:223698	30/128 (23%)
		GST_C_family	92..213	CDD:295467	22/84 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	218..296
		PTZ00419	282..1264	CDD:240411
		ValRS_core	335..938	CDD:185677
		'HIGH' region	344..354
		tRNA-synt_1_2	513..640	CDD:290334
		'KMSKS' region	862..866
		Anticodon_Ia_Val	938..1075	CDD:153416
		Val_tRNA-synt_C	1196..1258	CDD:287436
GstE10	NP_001286570.1	GstA	4..197	CDD:223698	43/193 (22%)
		GST_N_Delta_Epsilon	4..77	CDD:239343	18/87 (21%)
		GST_C_Delta_Epsilon	91..211	CDD:198287	22/85 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0625
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810