DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tacr2 and TkR86C

DIOPT Version :9

Sequence 1:	NP_542946.1	Gene:	Tacr2 / 25007	RGDID:	3812	Length:	390	Species:	Rattus norvegicus
Sequence 2:	NP_001097741.1	Gene:	TkR86C / 41286	FlyBaseID:	FBgn0004841	Length:	555	Species:	Drosophila melanogaster

Alignment Length:	401	Identity:	130/401 - (32%)
Similarity:	207/401 - (51%)	Gaps:	48/401 - (11%)

- Green bases have known domain annotations that are detailed below.

  Rat    26 FSMPGWQLALWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFN 90
            :.:|..|..:||..:..::.||:.||..|:||:..|..||||||||::||::|||.|::.|..||
  Fly    76 YELPWEQKTIWAIIFGLMMFVAIAGNGIVLWIVTGHRSMRTVTNYFLLNLSIADLLMSSLNCVFN 140

  Rat    91 FIYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAIIAGI 155
            ||:..::.|.||..:|...|......:..|::::.||:.|||:|||||.:.|.|....:.|:..|
  Fly   141 FIFMLNSDWPFGSIYCTINNFVANVTVSTSVFTLVAISFDRYIAIVHPLKRRTSRRKVRIILVLI 205

  Rat   156 WLVALALASPQCFYSTITV-----DEGATKCVVAWPNDNGGKML--LLYHLVVFVLIYFLPLLVM 213
            |.::..|::|...||:|..     .:..|.|.:.||:......:  ..|:|::.||.|.:|::||
  Fly   206 WALSCVLSAPCLLYSSIMTKHYYNGKSRTVCFMMWPDGRYPTSMADYAYNLIILVLTYGIPMIVM 270

  Rat   214 FGAYSVIGLTLW-KRAVPRHQAHGAN----LRHLQAKKKFVKAMVLVVLTFAICWLPYHLYFILG 273
            ...||::|..|| .|::      |.|    :..:::|:|.|:..:.:|..||||||||||:||..
  Fly   271 LICYSLMGRVLWGSRSI------GENTDRQMESMKSKRKVVRMFIAIVSIFAICWLPYHLFFIYA 329

  Rat   274 TFQEDIYYHKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF-RLAFRCCPWVTPTEED--R 335
            .....:...|::|.:||..:|||||:.|.||:||..:|.|||..| |:...||..:|....|  :
  Fly   330 YHNNQVASTKYVQHMYLGFYWLAMSNAMVNPLIYYWMNKRFRMYFQRIICCCCVGLTRHRFDSPK 394

  Rat   336 LELTHTPSLSRRVNRCHTKETLFMTGDMTHSEATNGQV----------------------GSPQD 378
            ..||:..|.:|     ||:....:...:.:|.....|.                      .||..
  Fly   395 SRLTNKNSSNR-----HTRGGYTVAHSLPNSSPPTTQTLLAVLAQTLTQPKPQTQLLLSHHSPHP 454

  Rat   379 GEPAGPICKAQ 389
            .:|:....|:|
  Fly   455 TQPSAAETKSQ 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tacr2	NP_542946.1	7tm_4	42..>168	CDD:304433	50/125 (40%)
		7tm_1	50..307	CDD:278431	99/268 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	365..390		7/47 (15%)
TkR86C	NP_001097741.1	7tm_4	92..376	CDD:304433	108/289 (37%)
TkR86C	NP_001097741.1	7tm_1	100..363	CDD:278431	99/268 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340889
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4219
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55548
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D314830at33208
OrthoFinder	1	1.000	-	-		FOG0000620
OrthoInspector	1	1.000	-	-		mtm9076
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X257
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.750