Protein Alignment ABL1 and slpr

DIOPT Version :10

• Sequence 1: NP_009297.2
• Gene: ABL1 / 25
• HGNCID: 76
• Length: 1149
• Species: Homo sapiens
• Sequence 2: NP_001188558.1
• Gene: slpr / 44111
• FlyBaseID: FBgn0030018
• Length: 1155
• Species: Drosophila melanogaster
• Alignment Length: 1234
• Identity: 271/1234 - (21%)
• Similarity: 420/1234 - (34%)
• Gaps: 409/1234 - (33%)

Human    81 DPNLFVALYDFVASGDNTLSITKGEKLRVLGYNH--NGE--WCEAQTKNGQGWVPSNYITPVNSL 141
            |.:|:.||||:.|.|::.|::.:||.:.||..:.  :|:  |...:..:..|..|.:::|
  Fly    44 DGSLWTALYDYDAQGEDELTLRRGEIVVVLSTDSEVSGDVGWWTGKIGDKVGVFPKDFVT----- 103

Human   142 EKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVS 206
                                            :..|.|.::|
  Fly   104 --------------------------------DEDPLQLNVS----------------------- 113

Human   207 SESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQ 271
                           |.:.|                    :.|:    |:|..::.:|..:|.|.
  Fly   114 ---------------SAIGD--------------------IQPH----EIEYNELDIKEVIGSGG 139

Human   272 YGEVYEGVW--KKYSLTVAVKTLKEDTMEV-EEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYII 333
            :.:|:.|.:  ::.::.:|.:|.::|...: :..|:||.:...:||.|:..|.|||. .....::
  Fly   140 FCKVHRGYYDGEEVAIKIAHQTGEDDMQRMRDNVLQEAKLFWALKHENIAALRGVCL-NTKLCLV 203

Human   334 TEFMTYGNLLDYLRECNR---QEVNAVVLLYMATQISSAMEYLEKK---NFIHRDLAARNCLVGE 392
            .|:...|:|       ||   .::...||:..|.||:..|.||..:   :.|||||.:.|.|:.|
  Fly   204 MEYARGGSL-------NRILAGKIPPDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYE 261

Human   393 ----NHL----VKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLW 449
                |||    :|:.||||:|.|......:.||.   ..|..||.::.:.:|..||||::|||||
  Fly   262 AIEGNHLQQKTLKITDFGLAREMYNTQRMSAAGT---YAWMPPEVISVSTYSKFSDVWSYGVLLW 323

Human   450 EIATYGMSPYPGID-LSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFE 513
            |:.| |.:||.|.| ||..|.:......:..|:.|||....||::|||.:|..||.|.||.:..|
  Fly   324 ELIT-GETPYKGFDPLSVAYGVAVNTLTLPIPKTCPETWGALMKSCWQTDPHKRPGFKEILKQLE 387

Human   514 TMF--------QESSISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMP 570
            ::.        |||.   ...:|..::.:.|.:..|              |..|.|..| :.|..
  Fly   388 SIACSKFTLTPQESF---HYMQECWRKEIAGVLHDL--------------REKEKRFQT-IEEEL 434

Human   571 HSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLL-----------PKDKKTNLFSALIK 624
            .:|.:......:.:...:.||..:|:     .|.|.||:|           |..:|.       |
  Fly   435 RNKEEQLLRVQNEQREKANLLKIREQ-----NLRERERVLIERELVMLQPVPSKRKH-------K 487

Human   625 KKKKTAPTPPKRSSSFR----------EMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSP 679
            |.||..|......:.||          |..|.|...|.......|...|. .:.|.......:|.
  Fly   488 KGKKNKPLQISLPTGFRHTITAVRDKAEQPGSPSFSGLRIVALTDGHKGK-TWGPSTMHQRERSL 551

Human   680 KPSN-GAGVPNGALRESGGSGF--RSPHLWKKSSTLTSSRLAT-----------GEEEGGGSSSK 730
            .||. ..|.|....:.|..|.|  .:|:|.||.......::|:           |....||:.:.
  Fly   552 LPSQLSGGQPEWPAQTSTHSSFSKSAPNLDKKQQQQNQQQVASLTPPPGLGILGGSGGAGGTPAT 616

Human   731 RFL----------------RSCSA----------------------------------SCVPHGA 745
            ..|                .:|.|                                  |.:....
  Fly   617 PLLYPGIPIILTRPNNNNIGNCKAITTTITTTTTTTTNNNNNNNNSISANNNNQLNNISTINSNN 681

Human   746 KDTEWRSVTLPRD---LQSTGRQFDSSTFGGHKSEKPA--LPRKRAGENRSDQVTRGTVTPPP-R 804
            .:.:....:.|..   ||:.....:|||    .|:.||  ..|.|:.|...|...  ...||| .
  Fly   682 NNNQTNLTSQPNTIIVLQNGRNNSNSST----TSQSPAKIYHRARSQEYGLDHPL--AYQPPPLY 740

Human   805 LVKKNEEAADEVFKDIMESSP---------GSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSA 860
            ||..:....|.|      :||         |:|               :.|||..|....| ||.
  Fly   741 LVTDDSSETDTV------ASPTGCFHFLKSGNS---------------SAASGAVHLHRFG-GSL 783

Human   861 LGTPAAAEPVTPTSKAGSGAPGGTSKG---------PAEESRVRRH--------KHSSESPGRDK 908
            ..:||..........:....|...|..         |:|::....|        |.|..|..|..
  Fly   784 GNSPAVGRKKHSLDSSSHHPPANGSNSFALPNQLTLPSEDNNTYDHAFYRDVIKKMSMASSERVN 848

Human   909 GKLS---RLKPAPPPPPAASAGKA-----GGK------PSQSP------SQEAAGEAVLGAKTKA 953
            .|.|   .:..:..|..|.....|     ||:      .||.|      .||..|||  ..:...
  Fly   849 SKSSGDLTMYNSSTPLTARDCDDAEEAFEGGRFQRNFSGSQFPRHCFFTRQEEEGEA--EDEDAV 911

Human   954 TSLVDAVNSDAAKPSQ-PGEGLK-------------------KPVLPATPKPQSAK---PSGTPI 995
            .:.||..::||....| |...::                   :|...|||:..:..   .|...|
  Fly   912 AAEVDTADADADDECQVPASQMRQNSTTSRKSSVTFQSVSFEEPDFVATPRTTARSDLYTSSASI 976

Human   996 SPAPVPSTLP--SASSALAGDQPS--STAFI--------PLISTR-----------VSLR----- 1032
            |.|...|..|  |:||..|...||  ||..:        .:::||           :.||
  Fly   977 SFATYRSASPSLSSSSTTASASPSIASTEAVNGYHMQENSILNTRRMQDVQPHPDVIKLRAQEQR 1041

Human  1033 -----KTRQPPERIASG----AITKGVVLDSTEALCLAISRNSEQMASHSA---VLEAGKNLYT 1084
                 :.:|.|:.|...    |..:|...:..:       .|..|...|||   .:.|..||:|
  Fly  1042 QQTKNQKKQRPKHITKSKSVEAPVEGQHHEHDD-------HNDPQHQHHSAGSSKIRALFNLFT 1098

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABL1	NP_009297.2	SH3_Abl	84..137	CDD:212784	16/56 (29%)
		SH2_ABL	142..235	CDD:198189	5/92 (5%)
		PTKc_Abl	254..516	CDD:270645	92/279 (33%)
		FABD	1025..1149	CDD:197885	18/88 (20%)
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809	17/93 (18%)
		STKc_MLK	134..389	CDD:270963	89/266 (33%)