DRSC/TRiP Functional Genomics Resources

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Protein Alignment ABL1 and Crk

DIOPT Version :10

Sequence 1:NP_009297.2 Gene:ABL1 / 25 HGNCID:76 Length:1149 Species:Homo sapiens
Sequence 2:NP_651908.1 Gene:Crk / 43775 FlyBaseID:FBgn0024811 Length:271 Species:Drosophila melanogaster


Alignment Length:199 Identity:51/199 - (25%)
Similarity:82/199 - (41%) Gaps:61/199 - (30%)


- Green bases have known domain annotations that are detailed below.


Human   142 EKHSWYHGPVSR-NAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTA--SDGKL 203
            :::|||.||:|| :|.|.|::....|.||||:|.|..|...:.:|.:.:|.:|.||..  .|..:
  Fly     8 DRNSWYFGPMSRQDATEVLMNERERGVFLVRDSNSIAGDYVLCVREDTKVSNYIINKVQQQDQIV 72

Human   204 YVSSESRFNTLAELVHHHSTVADGLITTLHY--------PAPKRNKPTVYGVSPNYDKWEMERTD 260
            |...:..|:.|.:|:..:         ||||        ||.:|    |..|...:|....::.|
  Fly    73 YRIGDQSFDNLPKLLTFY---------TLHYLDTTPLKRPACRR----VEKVIGKFDFVGSDQDD 124

Human   261 ITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKED-------------------TMEVEEFLKEA 306
            :..       |.|||         ||:..|  .||                   ..:.::::.|.
  Fly   125 LPF-------QRGEV---------LTIVRK--DEDQWWTARNSSGKIGQIPVPYIQQYDDYMDED 171

Human   307 AVMK 310
            |:.|
  Fly   172 AIDK 175

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABL1NP_009297.2 SH3_Abl 84..137 CDD:212784
SH2_ABL 142..235 CDD:198189 32/103 (31%)
PTKc_Abl 254..516 CDD:270645 13/76 (17%)
FABD 1025..1149 CDD:197885
CrkNP_651908.1 SH2_CRK_like 4..108 CDD:198180 35/112 (31%)
SH3_CRK_N 109..163 CDD:212692 12/71 (17%)
SH3_CRK_C 201..257 CDD:212693
Blue background indicates that the domain is not in the aligned region.

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