DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ABL1 and htl

DIOPT Version :10

Sequence 1:NP_009297.2 Gene:ABL1 / 25 HGNCID:76 Length:1149 Species:Homo sapiens
Sequence 2:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster


Alignment Length:591 Identity:168/591 - (28%)
Similarity:247/591 - (41%) Gaps:149/591 - (25%)


- Green bases have known domain annotations that are detailed below.


Human    39 CNVF--VEHEALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSI 101
            ||..  :.|:.  :.:.||          |.|.|..|:.||.    ||             ||.:
  Fly   177 CNSLGCIRHDT--QVIVSD----------RVNHKPILMTGPL----NL-------------TLVV 212

Human   102 TKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNS------------------LEKHSWYH 148
            ..      .|..|.....:..:|....:||.:.:|..::                  :|:..||.
  Fly   213 NS------TGSMHCKYLSDLTSKKAWIFVPCHGMTNCSNNRSIIAEDKDQLDFVNVRMEQEGWYT 271

Human   149 GPVSR-----NAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSE 208
            ...|.     |:..||   .:..|..|.|:    |..|.||.....||.:    ...|.:::...
  Fly   272 CVESNSLGQSNSTAYL---RVVRSLHVLEA----GVASGSLHSTSFVYIF----VFGGLIFIFMT 325

Human   209 SRFNTLAELVHHHSTVADGLITTLHYPAPK---------------------------RNKPTVY- 245
            :.|...|.....|..|....|.|:|....|                           :.:.||. 
  Fly   326 TLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQ 390

Human   246 -GVSP----NYD-----KWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTM--E 298
             |..|    .|:     .||:.|:.:.:...||.|.:|.|.  :.:..:..||||.:||...  :
  Fly   391 NGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVV--MAEVNNAIVAVKMVKEGHTDDD 453

Human   299 VEEFLKEAAVMKEI-KHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYL-------RECNRQE-- 353
            :...::|..|||.| :|.|::.|||.|::..|.|:|.|:..:|||.|:|       |:.:|..  
  Fly   454 IASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQ 518

Human   354 ---------VNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSR-LMT 408
                     :....|:..|.||:..|:||..:..|||||||||.||.:::::|:|||||:| :.:
  Fly   519 PPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQS 583

Human   409 GDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGI-DLSQVYELLE 472
            .|.|..:...:.||||.|||||....:..|||||::|:|||||.|||..|||.| ...::|..|.
  Fly   584 TDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLM 648

Human   473 KDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQES---------------SIS 522
            ...|||:|..|...:|.|||.||.:|..|||.|.||.:..:.:.|..               |.|
  Fly   649 SGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKEDYLDVDIANLDTPPSTS 713

Human   523 DEVEKE 528
            ||.|.|
  Fly   714 DEEEDE 719

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABL1NP_009297.2 SH3_Abl 84..137 CDD:212784 8/52 (15%)
SH2_ABL 142..235 CDD:198189 24/97 (25%)
PTKc_Abl 254..516 CDD:270645 110/284 (39%)
FABD 1025..1149 CDD:197885
htlNP_524394.2 Ig 101..191 CDD:472250 3/15 (20%)
Ig strand B 121..125 CDD:409353
Ig strand C 134..138 CDD:409353
Ig strand E 157..161 CDD:409353
Ig strand F 171..176 CDD:409353
Ig strand G 184..187 CDD:409353 1/2 (50%)
Ig 200..289 CDD:472250 20/114 (18%)
Ig strand B 216..220 CDD:409353 1/3 (33%)
Ig strand C 229..233 CDD:409353 1/3 (33%)
Ig strand E 255..259 CDD:409353 0/3 (0%)
Ig strand F 269..274 CDD:409353 2/4 (50%)
Ig strand G 282..285 CDD:409353 1/2 (50%)
Protein Kinases, catalytic domain 404..692 CDD:473864 110/289 (38%)
Blue background indicates that the domain is not in the aligned region.

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