Protein Alignment ABL1 and wnd

DIOPT Version :10

• Sequence 1: NP_009297.2
• Gene: ABL1 / 25
• HGNCID: 76
• Length: 1149
• Species: Homo sapiens
• Sequence 2: NP_649137.3
• Gene: wnd / 40143
• FlyBaseID: FBgn0036896
• Length: 977
• Species: Drosophila melanogaster
• Alignment Length: 922
• Identity: 217/922 - (23%)
• Similarity: 340/922 - (36%)
• Gaps: 249/922 - (27%)

Human   248 SPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAV--MK 310
            |...:.|::....||....||.|..|.|:.|..|  :.|||||.:||        |||..:  ::
  Fly   148 SQRSEDWQIPFESITELEWLGSGAQGAVFSGRLK--NETVAVKKVKE--------LKETDIKHLR 202

Human   311 EIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEK 375
            ::.|.|:::..||||:.|.|.||.||..||.|.:.|:|  .|.:....|:..:.||:..|:||..
  Fly   203 KLDHENIIKFKGVCTQSPVFCIIMEFCPYGPLQNILKE--EQVMLPSRLVSWSKQIALGMQYLHS 265

Human   376 KNFIHRDLAARNCLVGENHLVKVADFGLSRLMTG-DTYTAHAGAKFPIKWTAPESLAYNKFSIKS 439
            ...|||||.:.|.|:..|.:||::|||.||.... .|..:.||.   :.|.|||.:.....|.|.
  Fly   266 HKIIHRDLKSPNILISTNEVVKISDFGTSREWNEISTKMSFAGT---VAWMAPEVIRNEPCSEKV 327

Human   440 DVWAFGVLLWEIATYGMSPYPGIDLSQ-VYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRP 503
            |:|::||:|||:.|..: ||..:|.|. ::.:.....::..|..|||....|::.||:..|.:||
  Fly   328 DIWSYGVVLWEMLTCEI-PYKDVDSSAIIWGVGNNSLKLLVPSTCPEGFKLLVKLCWKSKPRNRP 391

Human   504 SFAEI----------------HQAFETMFQESSISDEVE---KELGKQGVRGAVSTLLQAPELPT 549
            ||.:|                .|.|||   :.|..:||.   ||:.:.|      |.:...|
  Fly   392 SFRQILSHLDIAGPELLRKTEKQYFET---QKSWKEEVRSHLKEITQNG------TNIHKYE--- 444

Human   550 KTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKD- 613
            :....||.||.|...|:..:...|.|..:............|..||:     .:.|.||.||..
  Fly   445 QDLIKRRTAEWRHAQDIRMVYEDKLQKTNQLFFELSECMSQLQEKEK-----EIAERERKLPGSG 504

Human   614 -KKTNLFSALIKK----KKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTA 673
             |....|...|:|    :::..|.|    ::.::....|:.....|...:     .:.:..||:.
  Fly   505 YKPNRRFGNTIRKMQHYRRRLNPAP----AAIQQQSTTPDPETTPESPVK-----CMLYAQLDSN 560

Human   674 DPAKS------PKPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRF 732
            ...||      |....||.:||                                      .:|:.
  Fly   561 CQPKSYLANIIPSSGLGAPMPN--------------------------------------KNKKV 587

Human   733 LRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAG--ENRSDQ-V 794
            .|.                            |:..|.:||......|...|:...  |||..| |
  Fly   588 FRH----------------------------RRNASGSFGAPPKYSPTRDRRYQSEPENRKVQLV 624

Human   795 TRGTVTPPPRLVKKNEEAADEVFKDIMES--SPGSSP-----PN--LTPKPLRRQVTVAPASGLP 850
            .|.|.|          :|.|....||..|  :|.|.|     ||  ..|..|:|...:|.|
  Fly   625 ERQTQT----------DAMDVSETDISPSAEAPRSQPIDVPVPNHRQLPLQLQRVQKIAQA---- 675

Human   851 HKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGR--------- 906
             :..|..||......|..|..|::        |.|...:|.:    ::.:..||.:
  Fly   676 -QARARSGSTSSAAGAVNPACPSN--------GNSLSTSELT----YQDACSSPDQLIDDVMNSN 727

Human   907 ----------DKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVN 961
                      |...|.||               |.|..     |...|..|..::...|:.:|.|
  Fly   728 ERLDMTECCSDNENLERL---------------GRKVI-----EFINENRLSIQSNTNSVSNADN 772

Human   962 SD-AAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSAS------SALAGDQPSST 1019
            .: .|.|.:..|....|.|.......| |....|:...|..|::.:|:      .:.:.::..:|
  Fly   773 GNGGASPLELRESGNSPCLSRCSSTHS-KRRKHPLGDNPNGSSIGNANGESHEQDSWSDEEGETT 836

Human  1020 AFIPLISTRVSLRKT---RQP------PERIASGAITKGVVLDSTEALCLAISRNSEQMASHS-- 1073
            .:      :.:||:.   |||      |.|.....:::.:.:.....:.::....:....|||
  Fly   837 DY------KYALRRRSIGRQPIARGMRPRRSYKAPLSQKIAIHKRNVVIVSDEEENTSEYSHSPS 895

Human  1074 ---AVLEAGKNL 1082
               :.||:..::
  Fly   896 SQHSTLESNTDI 907

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABL1	NP_009297.2	SH3_Abl	84..137	CDD:212784
		SH2_ABL	142..235	CDD:198189
		PTKc_Abl	254..516	CDD:270645	97/281 (35%)
		FABD	1025..1149	CDD:197885	12/72 (17%)
wnd	NP_649137.3	STKc_MAP3K12_13	167..403	CDD:270961	90/251 (36%)