Protein Alignment ABL1 and Tak1

DIOPT Version :10

• Sequence 1: NP_009297.2
• Gene: ABL1 / 25
• HGNCID: 76
• Length: 1149
• Species: Homo sapiens
• Sequence 2: NP_524080.1
• Gene: Tak1 / 39659
• FlyBaseID: FBgn0026323
• Length: 678
• Species: Drosophila melanogaster
• Alignment Length: 522
• Identity: 130/522 - (24%)
• Similarity: 215/522 - (41%)
• Gaps: 119/522 - (22%)

Human   259 TDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGV 323
            ::||::.|:|.|.||.|.:.||:  ...||||.... :.|.::..||...:..:||||::.|.|:
  Fly    17 SEITLREKVGHGSYGVVCKAVWR--DKLVAVKEFFA-SAEQKDIEKEVKQLSRVKHPNIIALHGI 78

Human   324 CTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLE---KKNFIHRDLAA 385
            .:.:...|:|.||...|:|.::|....:...:....:..|.|.:..:.||.   .|..||||:..
  Fly    79 SSYQQATYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAEGLAYLHAMTPKPLIHRDVKP 143

Human   386 RNCLV---GENHLVKVADFGL----SRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWA 443
            .|.|:   |.|  :|:.|||.    |.:||.:..:|        .|.|||....:|::.|.|:::
  Fly   144 LNLLLTNKGRN--LKICDFGTVADKSTMMTNNRGSA--------AWMAPEVFEGSKYTEKCDIFS 198

Human   444 FGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERP---EGCPEKVYELMRACWQWNPSDRPS- 504
            :.::|||:.: ...|:.|||  ..|.:..|.|:.|||   ..||:::.:||.|||:..|.||||
  Fly   199 WAIVLWEVLS-RKQPFKGID--NAYTIQWKIYKGERPPLLTTCPKRIEDLMTACWKTVPEDRPSM 260

Human   505 ----------------------FAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPEL 547
                                  :..::|...|...:.:::.:.:....::|.....||.|    .
  Fly   261 QYIVGVMHEIVKDYTGADKALEYTFVNQQIVTKESDGTVAAQPDSLSSQEGELSPSSTQL----T 321

Human   548 PT-------------KTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPP 599
            ||             ||.|| ...|:..:|.....|.:.||.:::||.:      ::..:....|
  Fly   322 PTTAANANVNAIAISKTTTS-SMTENTSSTSSDITPTNSGQLDNNPLFY------MVTNRWDAIP 379

Human   600 EGGLNEDERLLPKDKKTNLFSA---------------LIKKKKKTAPTPPKRSSSFREMDGQPER 649
            |...||.     ::...||.|:               |:..|.....|....::.|   |..|..
  Fly   380 EEESNES-----RNDSFNLTSSAEATQRLETIRNGMILMACKPMEQLTLDVEANGF---DLSPSE 436

Human   650 RGAGEEEGRDISNGALAFTPLDTADPAKSPKP--------SNGAGV---PNGALRESGGSGFRSP 703
            ..:.....:  |:|....|..||       ||        :|..|:   .||.|..:.|...|..
  Fly   437 SSSSSTNAK--SDGRERLTVTDT-------KPVMMTTDLSNNNGGIHAHSNGLLSHANGWQARDE 492

Human   704 HL 705
            .|
  Fly   493 EL 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABL1	NP_009297.2	SH3_Abl	84..137	CDD:212784
		SH2_ABL	142..235	CDD:198189
		PTKc_Abl	254..516	CDD:270645	85/292 (29%)
		FABD	1025..1149	CDD:197885
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	80/265 (30%)